Laura McLane and Mike Betts -Purified human CD8 T-cells were stained with a-T-bet (green), a-Lamin A (pink), and DAPI (blue) and imaged on a multilaser-based spinning disk confocal microscope (Zeiss). T-bet can be localized to both the nuclear and cytoplasmic compartments of specific subsets of human CD8 T-cells.
3D image of the inflamed meningeal membrane of a CX3CR1-GFP reporter mouse infected with Toxoplasma gondii. The dura mater that surrounds the brain is blue, blood vessels are labeled red and microglia and macrophages are green. Contributors for image are ChristophKonradt and Chris Hunter.
Time series of cells expressing GFP-tagged ebola viral protein VP40, pseudocolored as a fluorescence intensity heatmap. The contributors for image are: Gordon Ruthel, Xiaohong Liu, Ron Harty, and Bruce Freedman.
The IFI Cancer Immunology research program aims to advance the understanding of the immune system's role in neoplastic pathophysiology. Our work spans basic science discoveries, to translational medicine, to clinical care and epidemiology. A major goal is to utilize new insights of immune mechanisms to target malignant cells in relevant in vitro and animal model systems and in human clinical trials.
Cancer Program Highlights
The 1st Annual Abramson Cancer Center and Institute For Immunlogy Cancer Immunobiology Retreat took place on Thursday, December 18th from 9am-3pm in Smilow Rm 12-146. The retreat was a resounding success with 30 PI's participating.. The purpose of the retreat was to foster greater collaboration and interaction within the cancer immunology community at Penn.