The focus of the Transplantation Immunology Program is alloimmunity associated with human solid organ and bone marrow transplantation therapies. Its members cover a broad range of immunological disciplines, including tolerance, inflammation, and innate, adaptive, and molecular mechanisms of alloimmunity. Specific areas of expertise include immunosuppression, ischemia-reperfusion injury, humoral and cellular mechanisms of acute rejection and chronic allograft dysfunction, cellular and molecular mechanisms of tolerance, and the impact of resident microbial populations on transplant immunity. In addition to models of transplantation, Transplantation Immunology Program members are also engaged in translational research involving human populations. As such, there is a major emphasis on team science that aligns clinicians and researchers to promote sharing of patient samples for relevant research, which in turn is used for efficient cycling of lab and human science, ideally positioning this group for strategic funding initiatives.