Printable Timetable


Wine & Cheese Reception: October 22, 2012 at 6:30pm

Registration Hours:

October 22, 2012 from 7:30am to 12pm

Day 1 - October 22, 2012

Time: 8:30 AM to 5:30 PM

    • Overview of covariate types
    • Motivations for covariate modeling
    • Exploratory analysis of covariate distributions and relation to individual parameters
    • Introduction to covariate model building and diagnostics using PsN and Xpose
    • Parameterization of covariate relationships
    • Hypothesis testing and diagnostics for individual covariate-parameter relationships
    • Overview of covariate model building methods
    • Standard stepwise covariate model building
    • Hands-on NONMEM 7, PsN and Xpose4: Exploratory analyses (GAM); Parameterization and individual parameter-covariate relation diagnostics.

Day 2 - October 23, 2012

Time: 8:30 AM to 5:30 PM

    • Recent advances in stepwise covariate modeling (linearization, cross-validation, bootstrap scm)
    • Full covariate modeling approaches
    • Other modeling approaches (Lasso, WAM, Genetic algorithms)
    • Time-varying covariates and error in covariate measurements
    • Missing covariate information
    • Evaluation and use of final covariate models
    • Hands-on computer exercises with NONMEM 7, PsN and Xpose4. Stepwise covariate modeling, Full model approach/WAM/Lasso, Models for time-varying covariates. Handling of missing covariate information. Evaluation of covariate models.