Covariate Model Building and Evaluation in NONMEM

Workshop location: (Click Here for the Map)
The Children's Hospital of Philadelphia

Colket Translational Research Building
3501 Civic Center Blvd,
Philadelphia, PA 19104

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Date and Time:
Monday, October 22 - Tuesday 23, 2012 From 8:30 AM to 5:30 PM Days 1 and 2

Workshop Description:

The Uppsala Pharmacometrics Group and is happy to announce a NONMEM Workshop on Covariate Model Building and Evaluation tailored for Intermediate and Advanced NONMEM users. The course will present modeling strategies, techniques and implementations for the handling of covariate information in population models. Traditional methods will be complemented with recent advances in covariate model building methodology and diagnostics for more efficient, robust and informed covariate models. Such new functionality particularly related to covariate modeling has been introduced in recent updates to PsN and Xpose4. Advantages and disadvantages of the different covariate model building methods will be presented and the relationship between modeling aim, data and suitable method discussed. Methods for handling missing covariates, Special considerations for handling time-varying covariates and covariates measured with error will be presented.

The course will consist of both lectures and hands-on computer exercises using NONMEM 7, PsN and Xpose 4. Self-instructive material is provided for further studies and exploration of additional examples within the field. The participants will be provided with a NONMEM library of examples.

The Uppsala group has been involved in developing pharmacometric models and methodology for over twenty years and has extensive experience in development of covariate models and covariate model building methodology. In parallel, model building procedures and informative diagnostics for covariate model building and covariate model evaluation have been developed, evaluated and integrated into the user-friendly software Perl-speaks-NONMEM (PsN) and Xpose 4 .


A prerequisite for the course is basic experience with performing NONMEM analyses.

Computer hardware/software :

The course will include hands-on training, with the participants working on their own computers. All programs will run from a USB memory-stick and participants will not be required to install any programs on their computer. All participants must bring their own Windows laptops.


For questions, please e-mail kmas@email.chop.edu

Prof Mats Karlsson

Local host:
Jeffrey Barrett, Ph.D., FCP
Director, Laboratory for Applied PK/PD
Research Professor, Department of Pediatrics
The Children's Hospital of Philadelphia