Publications
Complete publications list on PubMed
2023
The REV-ERB Nuclear Receptors: Timekeepers for the Core Clock Period and Metabolism.
Adlanmerini M, Lazar MA.
Endocrinology. 2023 Apr 17.
Hepatocyte SREBP signaling mediates clock communication within the liver.
Guan D, Bae H, Zhou D, Chen Y, Jiang C, La CM, Xiao Y, Zhu K, Hu W, Trinh TM, Liu P, Xiong Y, Cai B, Jang C, Lazar MA.
J Clin Invest. 2023 Apr 17.
Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis.
Xiao Y, Batmanov K, Hu W, Zhu K, Tom AY, Guan D, Jiang C, Cheng L, McCright SJ, Yang EC, Lanza MR, Liu Y, Hill DA, Lazar MA.
Sci Transl Med.2023 Feb 8.
2022
Modelling metabolic diseases and drug response using stem cells and organoids.
Hu W, Lazar MA.
Nat Rev Endocrinol. 2022 Dec.
Balanced control of thermogenesis by nuclear receptor corepressors in brown adipose tissue.
Richter HJ, Hauck AK, Batmanov K, Inoue SI, So BN, Kim M, Emmett MJ, Cohen RN, Lazar MA.
Proc Natl Acad Sci U S A. 2022 Aug.
Isoform-specific functions of PPARγ in gene regulation and metabolism.
Hu W, Jiang C, Kim M, Xiao Y, Richter HJ, Guan D, Zhu K, Krusen BM, Roberts AN, Miller J, Steger DJ, Lazar MA.
Genes Dev. 2022 Mar 1.
Nicotinamide Riboside Improves Cardiac Function and Prolongs Survival After Disruption of the Cardiomyocyte Clock.
Dierickx P, Carpenter BJ, Celwyn I, Kelly DP, Baur JA, Lazar MA.
Front. Mol. Med. Epub 2022 May 09. PDF
2021
Circadian REV-ERBs repress E4bp4 to activate NAMPT-dependent NAD+ biosynthesis and sustain cardiac function.
Dierickx P, Zhu K, Carpenter BJ, Jiang C, Vermunt MW, Xiao Y, Luongo TS, Yamamoto T, Martí-Pàmies I, Mia S, Latimer M, Diwan A, Zhao J, Hauck AK, Krusen B, Nguyen HCB, Blobel GA, Kelly DP, Pei L, Baur JA, Young ME, Lazar MA.
Nat Cardiovasc Res: 1-14. Epub 2021 Dec 23. PDF
REV-ERB nuclear receptors in the suprachiasmatic nucleus control circadian period and restrict diet-induced obesity.
Adlanmerini M, Krusen BM, Nguyen HCB, Teng CW, Woodie LN, Tackenberg MC, Geisler CE, Gaisinsky J, Peed LC, Carpenter BJ, Hayes MR, Lazar MA.
Sci Adv. 2021 Oct 29;7(44):eabh2007. doi: 10.1126/sciadv.abh2007. Epub 2021 Oct 27. PDF
Individual-specific functional epigenomics reveals genetic determinants of adverse metabolic effects of glucocorticoids.
Hu W, Jiang C, Kim M, Yang W, Zhu K, Guan D, Lv W, Xiao Y, Wilson JR, Rader DJ, Pui CH, Relling MV, Lazar MA.
Cell Metab. 2021 Aug 3;33(8):1592-1609.e7. doi: 10.1016/j.cmet.2021.06.004. Epub 2021 Jul 6. PDF
2020
Dichotomous engagement of HDAC3 activity governs inflammatory responses.
Hoang C B Nguyen, Marine Adlanmerini, Amy K Hauck, Mitchell A Lazar.
Nature. 2020 Aug; 584(7820) : 286-290. doi: 10.1038/s41586-020-2576-2. Epub 2020 Aug 5. PDF
The hepatocyte clock and feeding control chronophysiology of multiple liver cell types.
Dongyin Guan, Ying Xiong, Trang Minh Trinh, Yang Xiao, Wenxiang Hu, Chunjie Jiang, Pieterjan Dierickx, Cholsoon Jang, Joshua D Rabinowitz, Mitchell A Lazar.
Science. 2020 Jul 30; eaba8984. doi: 10.1126/science.aba8984 PDF
2019
Circadian lipid synthesis in brown fat maintains murine body temperature during chronic cold.
Adlanmerini M, Carpenter BJ, Remsberg JR, Aubert Y, Peed LC, Richter HJ, Lazar MA.
Proc Natl Acad Sci U S A. 2019 Aug 26. pii: 201909883. doi: 10.1073/pnas.1909883116. PDF
SR9009 has REV-ERB-independent effects on cell proliferation and metabolism.
Dierickx P, Emmett MJ, Jiang C, Uehara K, Liu M, Adlanmerini M, Lazar MA.
Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12147-12152. doi: 10.1073/pnas.1904226116. Epub 2019 May 24. PDF
Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response.
Hu W, Jiang C, Guan D, Dierickx P, Zhang R, Moscati A, Nadkarni GN, Steger DJ, Loos RJF, Hu C, Jia W, Soccio RE, Lazar MA.
Cell Stem Cell. 2019 Feb 7;24(2):299-308.e6. doi: 10.1016/j.stem.2018.11.018. Epub 2019 Jan 10.
Work featured on CellPress cover, click here to see the cover. PDF
2018
Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes
Guan D, Xiong Y, Borck PC, Jang C, Doulias PT, Papazyan R, Fang B, Jiang C, Zhang Y, Briggs ER, Hu W, Steger D, Ischiropoulos H, Rabinowitz JD, Lazar MA.
Cell. 2018 Aug 9;174(4):831-842.e12. doi: 10.1016/j.cell.2018.06.031. Epub 2018 Jul 26. PDF
PPARγ is a nexus controlling alternative activation of macrophages via glutamine metabolism.
Nelson VL, Nguyen HCB, Garcìa-Cañaveras JC, Briggs ER, Ho WY, DiSpirito JR, Marinis JM, Hill DA, Lazar MA.
Genes Dev. 2018 Jul 13. doi: 10.1101/gad.312355.118. [Epub ahead of print] PMID:30006480 PDF
Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue.
Hill DA, Lim HW, Kim YH, Ho WY, Foong YH, Nelson VL, Nguyen HCB, Chegireddy K, Kim J, Habertheuer A, Vallabhajosyula P, Kambayashi T, Won KJ, Lazar MA.
Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5096-E5105. doi: 10.1073/pnas.1802611115. Epub 2018 May 14. PMID: 29760084 PDF
Rev-erbα dynamically modulates chromatin looping to control circadian gene transcription.
Kim YH, Marhon SA, Zhang Y, Steger DJ, Won KJ, Lazar MA.
Science. 2018 Feb 8. pii: eaao6891. doi: 10.1126/science.aao6891. [Epub ahead of print]. PMID: 29439026 PDF
2017
An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides.
Armour SM, Remsberg JR, Damle M, Sidoli S, Ho WY, Li Z, Garcia BA, Lazar MA.
Nat Commun. 2017 Sep 15;8(1):549. doi: 10.1038/s41467-017-00772-5. PMID: 28916805 PDF
The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ.
Zhang Y, Papazyan R, Damle M, Fang B, Jager J, Feng D, Peed LC, Guan D, Sun Z, Lazar MA.
Genes Dev. 2017 Jul 26. doi: 10.1101/gad.302323.117. [Epub ahead of print] PMID: 28747429 PDF
Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge.
Emmett MJ, Lim HW, Jager J, Richter HJ, Adlanmerini M, Peed LC, Briggs ER, Steger DJ, Ma T, Sims CA, Baur JA, Pei L, Won KJ, Seale P, Gerhart-Hines Z, Lazar MA.
Nature. 2017 Jun 22;546(7659):544-548. doi: 10.1038/nature22819. Epub 2017 Jun 14. PMID: 28614293 PDF
Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice.
Soccio RE, Li Z, Chen ER, Foong YH, Benson KK, Dispirito JR, Mullican SE, Emmett MJ, Briggs ER, Peed LC, Dzeng RK, Medina CJ, Jolivert JF, Kissig M, Rajapurkar SR, Damle M, Lim HW, Won KJ, Seale P, Steger DJ, Lazar MA.
J Clin Invest. 2017 Apr 3;127(4):1451-1462. doi: 10.1172/JCI91211. Epub 2017 Feb 27. PMID: 28240605 PDF
Unraveling the Regulation of Hepatic Metabolism by Insulin.
Titchenell PM, Lazar MA, Birnbaum MJ.
Trends Endocrinol Metab. 2017 Jul;28(7):497-505. doi: 10.1016/j.tem.2017.03.003. Epub 2017 Apr 14. Review. PMID: 28416361 PDF
Maturing of the nuclear receptor family.
Lazar MA.
J Clin Invest. 2017 Apr 3;127(4):1123-1125. doi: 10.1172/JCI92949. Epub 2017 Apr 3. Review. PMID: 28368290 PDF
2016
Rev-erbs: Integrating Metabolism Around the Clock.
Lazar MA.
In: Sassone-Corsi P, Christen Y, editors. A Time for Metabolism and Hormones [Internet]. Cham (CH): Springer; 2016.2016 Apr 5. PMID: 28892343 PDF
Deletion of histone deacetylase 3 in adult beta cells improves glucose tolerance via increased insulin secretion.
Remsberg JR, Ediger BN, Ho WY, Damle M, Li Z, Teng C, Lanzillotta C, Stoffers DA, Lazar MA.
Mol Metab. 2016 Nov 22;6(1):30-37. doi: 10.1016/j.molmet.2016.11.007. eCollection 2017 Jan. PMID: 28123935 PDF
Genetic and epigenomic mechanisms of mammalian circadian transcription.
Papazyan R, Zhang Y, Lazar MA.
Nat Struct Mol Biol. 2016 Dec 6;23(12):1045-1052. doi: 10.1038/nsmb.3324. Review. PMID: 27922611 PDF
Circadian time signatures of fitness and disease.
Bass J, Lazar MA.
Science. 2016 Nov 25;354(6315):994-999. Review. PMID: 27885004 PDF
Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP.
Papazyan R, Sun Z, Kim YH, Titchenell PM, Hill DA, Lu W, Damle M, Wan M, Zhang Y, Briggs ER, Rabinowitz JD, Lazar MA.
Cell Metab. 2016 Dec 13;24(6):863-874. doi: 10.1016/j.cmet.2016.10.012. Epub 2016 Nov 17. PMID: 27866836 PDF
HNF6 and Rev-erbα integrate hepatic lipid metabolism by overlapping and distinct transcriptional mechanisms.
Zhang Y, Fang B, Damle M, Guan D, Li Z, Kim YH, Gannon M, Lazar MA.
Genes Dev. 2016 Jul 15;30(14):1636-44. doi: 10.1101/gad.281972.116. Epub 2016 Jul 21. PMID: 27445394 PDF
The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling.
Jager J, Wang F, Fang B, Lim HW, Peed LC, Steger DJ, Won KJ, Kharitonenkov A, Adams AC, Lazar MA.
J Biol Chem. 2016 May 13;291(20):10867-75. doi: 10.1074/jbc.M116.719120. Epub 2016 Mar 21. PMID: 27002153 PDF