Laboratory for Cognition and Neural Stimulation

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  • Roy H. Hamilton MD, MS

Roy H. Hamilton MD, MS

Roy H. Hamilton MD, MSDr. Roy Hamilton is a Professor in the departments of Neurology, Physical Medicine and Rehabilitation, and Psychiatry at the University of Pennsylvania, where he also directs the Laboratory for Cognition and Neural Stimulation (LCNS). He has been engaged in research in the field of brain stimulation since 1998, and has employed TMS and tDCS in a range of studies exploring a range of topics, including but not limited to cognitive control, visuospatial processing, language production, semantic memory, and creativity. He is a clinically trained behavioral neurologist and cognitive neuroscientist, and as such has dedicated his career to exploring the structure-function and network-function relationships that underpin complex human behaviors. Dr. Hamilton’s work has been supported by a variety of funding agencies, including the NIH, Robert Wood Johnson Foundation, American Academy of Neurology, Society for Neuroscience, Association for Frontotemporal Dementia, and Templeton Foundation. Dr. Hamilton also serves as Director of the Penn Clinical Neurosciences Training Program, an Assistant Dean for Diversity and Inclusion for the Perelman School of Medicine, and the Vice Chair of Diversity and Inclusion for the University of Pennsylvania Department of Neurology. He is the recipient of numerous accolades, including the American Academy of Neurology's Norman Geschwind Award for behavioral neurology research and Penn's Leonard Berwick Award for excellence in basic science and clinical education.

Publications

JOURNAL ARTICLES

  • Cehelyk, E.K., Harvey, D.Y., Grubb, M., Jalel, R., Elsibai, M.S., Hamilton, R.H., Chahin, S. : Uncovering the association between fatigue and fatigability in multiple sclerosis using cognitive control. Multiple Sclerosis and Related Disorders In Press.
  • Hosseini, M., McConathey, E.M., Ungrady, M. Grossman, M., Coslett, H.B., Hamilton, R.H.: Transcranial direct current stimulation mediates improvements in verbal fluency for patients with primary progressive aphasia (published proceedings). Brain Stimulation 12: e69-e70, 2019.
  • To, C., Falcone, M., Loughead, J., Logue-Chamberlain, E., Hamilton, R., Kable, J., Lerman, C., Ashare, R.L.: Got chocolate? Bilateral prefrontal cortex stimulation augments chocolate consumption. Appetite(131), 28-35, Dec 2018.
  • Medaglia, J.D., Harvey, D.Y., White, N., Kelkar, A., Zimmermann, J., Bassett, D.S., Hamilton, R.H. : Network controllability in the inferior frontal gyrus relates to controlled language variability and susceptibility to TMS. Journal of Neuroscience 38(28): 6399-6410, Jul 2018.
  • Choy,O., Raine,A., Hamilton, R.: Stimulation of the prefrontal cortex reduces intentions to commit aggression: A randomized, double-blind, placebo-controlled, stratified, parallel-group trial. Journal of Neuroscience 38(29): 6505-6512, Jul 2018.
  • Shah-Basak, P.P., Chen, P, Caulfield, K., Medina, J, Hamilton, R.: The role of the right superior temporal gyrus in stimulus-centered spatial processing Neuropsychologia 113: 6-13, Mar 2018.
  • Irwin, D., McMillan, C., Xie, S., Rascovsky, K., Van Deerlin, V., Coslett, H.B., Hamilton, R., Aguirre, G.K., Lee, E.B., Lee, V.M.Y., Grossman, M. (2018). Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia. Brain, 141, 288-301.
  • Harvey, D., Podell, J., Turkeltaub, P., Faseyitan, O., Coslett, H., & Hamilton, R. (2017). Functional reorganization of right prefrontal cortex underlies sustained naming improvements in chronic aphasia via repetitive transcranial magnetic stimulation. Cognitive and Behavioral Neurology, 30(4), 133-144.
  • McConathey, E., White, N., Gervits, F., Ash, S., Coslett, H., Grossman, M., & Hamilton, R. (2017). Baseline performance predicts tDCS-mediated improvements in language symptoms in primary progressive aphasia. Frontiers in Human Neuroscience, 11.
  • Norise, C., Sacchetti, D., & Hamilton, R. (2017). Transcranial direct current stimulation in post-stroke chronic aphasia: The impact of baseline severity and task specificity in a pilot sample. Frontiers in Human Neuroscience, 11.
  • Hung, J., Bauer, A., Grossman, M., Hamilton, R., Coslett, H., & Reilly, J. (2017). Semantic feature training in combination with transcranial direct current stimulation (tDCS) for progressive anomia. Frontiers in Human Neuroscience, 11.
  • Giordano, J., Bikson, M., Kappenman, E. S., Clark, V. P., Coslett, H. B., Hamblin, M. R., Hamilton, R., Jankord, R., Kozumbo, W. J., McKinley, R.A., Nitsche M.A., Reilly, J.P., Richardson, J., Wurzman, R., Calabrese, E. (2017). Mechanisms and effects of transcranial direct current stimulation. Dose-Response, 15(1).
  • Norise, C., & Hamilton, R. (2017). Non-invasive brain stimulation in the treatment of post-stroke and neurodegenerative aphasia: Parallels, differences, and lessons learned. Frontiers in Human Neuroscience, 10.
  • Medaglia, J., Pasqualetti, F., Hamilton, R., Thompson-Schill, S., & Bassett, D. (2017). Brain and cognitive reserve: Translation via network control theory. Neuroscience and Biobehavioral Reviews, 75, 53-64.
  • Karuza, E., Balewski, Z., Hamilton, R., Medaglia, J., Tardiff, N., & Thompson-Schill, S. (2016). Mapping the parameter space of tDCS and cognitive control via manipulation of current polarity and intensity. Frontiers in Human Neuroscience, 10(2016)
  • Rosen, D., Erickson, B., Kim, Y., Mirman, D., Hamilton, R., & Kounios, J. (2016). Anodal tDCS to right dorsolateral prefrontal cortex facilitates performance for novice jazz improvisers but hinders experts. Frontiers in Human Neuroscience, 10(2016)
  • Lee, Y., Zreik, J., & Hamilton, R. (2017). Patterns of neural activity predict picture-naming performance of a patient with chronic aphasia. Neuropsychologia, 94, 52-60.
  • Meletath, S., Pavlick, D., Brennan, T., Hamilton, R., Chmielecki, J., Elvin, J.A., Palma, N., Ross J.S., Miller V.A., Stephens, P.J., Snipes G., Rajaram, V., Ali, S.M., Melguizo-Gavilanes, I. (2016). Personalized treatment for a patient with a BRAF V600E mutation using dabrafenib and a tumor treatment fields device in a high-grade glioma arising from ganglioglioma. Journal of the National Comprehensive Cancer Network, 14(11), 1345-1350.
  • Gervits, F., Ash, S., Coslett, H., Rascovsky, K., Grossman, M., & Hamilton, R. (2016). Transcranial direct current stimulation for the treatment of primary progressive aphasia: An open-label pilot study. Brain and Language, 162, 35-41.
  • Hamilton, R. (2016). Neuroplasticity in the language system: Reorganization in post-stroke aphasia and in neuromodulation interventions. Restorative Neurology and Neuroscience, 34(4), 467-471.
  • Wurzman, R., Hamilton, R. H., Pascual‐Leone, A., & Fox, M. D. (2016). An open letter concerning do‐it‐yourself users of transcranial direct current stimulation. Annals of Neurology, 80(1), 1-4.
  • Shah-Basak, P., Wurzman, R., Purcell, J., Gervits, F., & Hamilton, R. (2016). Fields or flows? A comparative metaanalysis of transcranial magnetic and direct current stimulation to treat post-stroke aphasia. Restorative Neurology and Neuroscience, 34(4), 537-558.
  • Mancuso, L. E., Ilieva, I. P., Hamilton, R. H., & Farah, M. J. (2016). Does transcranial direct current stimulation improve healthy working memory?: A meta-analytic review. Journal of Cognitive Neuroscience, 28(8), 1063-1089.
  • Price, A., Peelle, J., Bonner, M., Grossman, M., & Hamilton, R. (2016). Causal evidence for a mechanism of semantic integration in the angular gyrus as revealed by high-definition transcranial direct current stimulation. Journal of Neuroscience, 36(13), 3829-3838.
  • Barrett, A. M., & Hamilton, R. H. (2016). Drawing on the right brain for aphasia recovery. Neurology, 86(17), 1566-1567.
  • Julian, J., Ryan, J., Hamilton, R., & Epstein, R. (2016). The occipital place area is causally involved in representing environmental boundaries during navigation. Current Biology, 26(8), 1104-1109.
  • Hamilton, R. H. (2016). Enhancing diversity in academic neurology: From agnosia to action.Annals of Neurology, 79(5), 705-708.
  • Falcone, M., Bernardo, L., Ashare, R., Hamilton, R., Faseyitan, O., McKee, S., Louoghead, J., Lerman, C. (2016). Transcranial direct current brain stimulation increases ability to resist smoking. Brain Stimulation, 9(2), 191-196.
  • Medina, J., Drebing, D.E., Hamilton, R.H., Coslett, H.B. Phantoms on the hands: influence of the body on brief synchiric visual percepts. Neuropsychologia 82: 104-109, Jan 2016. 
  • Price, A.R., Hamilton, R.H. A re-evaluation of the cognitive effects from single-session transcranial direct current stimulation. Brain Stimulation 8(3): 663-5, May-June 2015.
  • Woods, A.J., Bryant, V., Sacchetti, D., Gervits, F., Hamilton, R. Effects of electrode drift in transcranial direct current stimulation. Brain Stimulation 8(3): 515-9, May-June 2015.
  • Gill, J., Shah-Basak, P.P., Hamilton, R. It's the thought that counts: examining the task-dependent effects of transcranial direct current stimulation on executive function. Brain Stimulation 8(2): 253-9, Mar-Apr 2015. 
  • Chen, H.I., Attiah, M., Baltuch, G., Smith, D.H., Hamilton, R.H., Lucas, T.H. Harnessing plasticity for the treatment of neurosurgical disorders: an overview. World Neurosurgery 82(5): 648-59, Nov 2014. 
  • Woods, A.J., Hamilton, R.H., Kranjec, A., Minhaus, P., Bikson, M., Yu, J., Chatterjee, A. Space, time, and causality in the human brain. Neuroimage 92: 285-97, May 2014. 
  • Hamilton, R.H., Zreik, J. Wired for thought. Scientific American 310(2): 12, Feb 2014.
  • Farah, M.J., Smith, M.E., Ilieva, I., Hamilton, R.H. Cognitive enhancement. Wiley Interdisciplinary Reviews: Cognitive Science 5(1): 95-103, Jan 2014.
  • Kraemer, D.J., Hamilton, R.H., Messing, S.B., Desantis, J.H., Thompson-Schill, S.L. Cognitive style, cortical stimulation, and the conversion hypothesis. Frontiers in Human Neuroscience 8: 15, Jan 2014. 
  • Cabrera, L.Y., Evans, E.L., Hamilton, R.H. Ethics of the electrified mind: defining issues and perspectives on the principled use of brain stimulation in medical research and clinical care. Brain Topography 27(1): 33-45, Jan 2014.
  • Shah, P.P., Szaflarski, J.P., Allendorfer, J., Hamilton, R.H. Induction of neuroplasticity and recovery in post-stroke aphasia by non-invasive brain stimulation. Frontiers in Human Neuroscience 7: 888, Dec 2013. 
  • Hamilton, R.H., Wiener, M., Drebing, D.E., Coslett, H.B. Gone in a flash: manipulation of audiovisual temporal integration using transcranial magnetic stimulation. Frontiers in Psychology 4: 571, Sept 2013. 
  • Garcia, G., Norise, C., Faseyitan, O., Naeser, M.A., Hamilton, R.H. Utilizing repetitive transcranial magnetic stimulation to improve language function in stroke patients with chronic non-fluent aphasia. Journal of Visualized Experiments (77): e50228, July 2013. 
  • Mesquita, R.C., Faseyitan, O.K., Turkeltaub, P.E., Buckley, E.M., Thomas, A., Kim, M.N., Durduran, T., Greenberg, J.H., Detre, J.A., Yodh, A.G., Hamilton, R.H. Blood flow and oxygenation changes due to low-frequency repetitive transcranial magnetic stimulation of the cerebral cortex. Journal of Biomedical Optics 18(6): 067006, June 2013.
  • Medina, J., Beauvais, J., Datta, A., Bikson, M., Coslett, H.B., Hamilton, R.H. Transcranial direct current stimulation accelerates allocentric target detection. Brain Stimulation 6(3): 433-9, May 2013. 
  • De Rojas, J.O., Saunders, J.A., Luminais, C., Hamilton, R.H., Siegel, S.J. Electroencephalographic changes following direct current deep brain stimulation of auditory cortex: a new model for investigating neuromodulation. Neurosurgery 72(2): 267-75; discussion 275, Feb 2013. 
  • Torres, J., Drebing, D., Hamilton, R. TMS and tDCS in post-stroke aphasia: integrating novel treatment approaches with mechanisms of plasticity. Restorative Neurology and Neuroscience 31(4): 501-15, Jan 2013. 
  • Chrysikou, E.G., Hamilton, R.H., Coslett, H.B., Datta, A., Bikson, M., Thompson-Schill, S.L. Noninvasive transcranial direct current stimulation over the left prefrontal cortex facilitates cognitive flexibility in tool use. Cognitive Neuroscience 4(2):81-9, 2013.
  • Turkeltaub, P.E., Coslett, H.B., Thomas, A.L., Faseyitan, O., Benson, J., Norise, C., Hamilton, R.H. The right hemisphere is not unitary in its role in aphasia recovery. Cortex 48(9): 1179-86, Oct 2012. 
  • Medina, J., Norise, C., Faseyitan, O., Coslett, H.B., Turkeltaub, P.E., Hamilton, R.H. Finding the right words: transcranial magnetic stimulation improves discourse productivity in non-fluent aphasia after stroke. Aphasiology 26(9): 1153-1168, Sept 2012.
  • Wiener, M., Kliot, D., Turkeltaub, P.E., Hamilton, R.H., Wolk, D.A., Coslett, H.B. Parietal influence on temporal encoding indexed by simultaneous transcranial magnetic stimulation and electroencephalography. The Journal of Neuroscience 32(35): 12258-67, Aug 2012. 
  • Lupyan, G., Mirman, D., Hamilton, R., Thompson-Schill, S.L. Categorization is modulated by transcranial direct current stimulation over left prefrontal cortex. Cognition 124(1): 36-49, July 2012. 
  • Turkeltaub, P.E., Benson, J., Hamilton, R.H., Datta, A., Bikson, M., Coslett, H.B. Left lateralizing transcranial direct current stimulation improves reading efficiency. Brain Stimulation 5(3): 201-7, July 2012. 
  • Kessler, S.K., Turkeltaub, P.E., Benson, J.G., Hamilton, R.H. Differences in the experience of active and sham transcranial direct current stimulation. Brain Stimulation 5(2): 155-62, Apr 2012.
  • Patel, S., Lee, E.B., Xie, S.X., Law, A., Jackson, E.M., Arnold, S.E., Clark, C.M., Shaw, L.M., Grady, M.S., Trojanowski, J.Q., Hamilton, R.H. Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalus. Fluids and Barriers of the CNS 9(1): 7, Mar 2012.
  • Chin, A.L., Negash, S., Xie, S., Arnold, S.E., Hamilton, R. Quality, and not just quantity, of education accounts for differences in psychometric performance between African American and White Non-Hispanics with Alzheimer's disease. Journal of the International Neuropsychological Society 18(2): 277-85, Mar 2012.
  • Wolk, D.A., Grachev, I.D., Buckley, C., Kazi, H., Grady, M.S., Trojanowski, J.Q., Hamilton, R.H., Sherwin, P., McLain, R., Arnold, S.E. Association between in vivo fluorine 18-labeled flutemetamol amyloid positron emission tomography imaging and in vivo cerebral cortical histopathology. Archives of Neurology 68(11): 1398-403, Nov 2011. 
  • Chin, A.L., Negash, S., Hamilton, R. Diversity and disparity in dementia: the impact of ethnoracial differences in Alzheimer disease. Alzheimer Disease and Associated Disorders 25(3): 187-95, July-Sept 2011. 
  • Hamilton, R.H., Chrysikou, E.G., Coslett, B. Mechanisms of aphasia recovery after stroke and the role of noninvasive brain stimulation. Brain and Language 118(1-2): 40-50, July 2011. 
  • Turkeltaub, P.E., Messing, S., Norise, C., Hamilton, R.H. Are networks for residual language function and recovery consistent across aphasic patients? Neurology 76(20): 1726-34, May 2011.
  • Hamilton, R., Messing, S., Chatterjee, A. Rethinking the thinking cap: ethics of neural enhancement using noninvasive brain stimulation. Neurology 76(2): 187-93, Jan 2011.
  • Coslett, H.B., Hamilton, R. Non-invasive brain current stimulation in neurorehabilitation. Restorative Neurology and Neuroscience 29(6): 361-3, 2011. 
  • Chrysikou, E.G., Hamilton, R.H. Noninvasive brain stimulation in the treatment of aphasia: exploring interhemispheric relationships and their implications for neurorehabilitation. Restorative Neurology and Neuroscience 29(6): 375-94, 2011. 
  • Hamilton, R., Stark, M., Coslett, H.B. Increased effect of target eccentricity on covert shifts of visual attention in patients with neglect. Cortex 46(1): 68-76, 2010.
  • Hamilton, R., Patel, S., Lee, E.B., Jackson, E.M., Lopinto, J., Arnold, S.E., Clark, C.M., Basil, A., Shaw, L.M., Xie, S.X., Grady, M.S., Trojanowski, J.Q. Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology. Annals of neurology 68(4): 535-40, Oct 2010.
  • Hamilton, R.H., Sanders, L., Benson, J., Faseyitan, O., Norise, C., Naeser, M., Martin, P., Coslett, H.B. Stimulating conversation: enhancement of elicited propositional speech in a patient with chronic non-fluent aphasia following transcranial magnetic stimulation. Brain and language 113(1): 45-50, Apr 2010.
  • Wiener M., Hamilton R., Turkeltaub P., Matell M., Coslett B. Fast forward: supramarginal gyrus stimulation alters time measurement. Journal of Cognitive Neuroscience 22(1): 22-31, 2009.
  • Hindy, N.C., Hamilton, R.H., Houghtling, A.S., Coslett, H.B., Thompson-Schill, S.L. Computer-mouse tracking reveals TMS disruptions of prefrontal function during semantic retrieval. Journal of Neurophysiology 102(6): 3405-3413, 2009.
  • Merabet, L.B., Hamilton, R., Schlaug, G., Swisher, J.D., Kiriakopoulos, E.T., Pitskel, N.B., Kauffman, T., Pascual-Leone, A. Rapid and reversible recruitment of early visual cortex for touch. PLoS ONE 3(8): 1-12, 2008.
  • Hamilton, R.H. Coslett, H.B., Buxbaum, L.J., Whyte, J., Ferraro, M.K. Inconsistency of performance on neglect subtype tests following acute right hemisphere stroke. Journal of the International Neuropsychological Society 14(1): 23-32, 2008.
  • Edlow, L.B., Hamilton, K., Hamilton, R.H. Teaching about the brain and reaching the community: Undergraduates in the Pipeline Program at the University of Pennsylvania. Journal of Undergraduate Neuroscience Education 5(2): A63-A70, 2007.
  • Hamilton, R.H., Hamilton, K., Jackson, B. Dahodwala, N. Teaching: residents in the hospital, mentors in the community: the Educational Pipeline Program at Penn. Neurology 68(19): E25-8, May 2007.
  • Sullivan, J., Hamilton, R., Hurford, M., Galetta, S.L., Liu, G.T. Neuroopthalmic findings in Wernicke's encephalopathy after gastric bypass surgery. Neuro-Opthalmology 30: 1-5, 2006.
  • Chatterjee, A., Hamilton, R.H., Amorapanth, P.X. Art produced by a patient with Parkinson's disease. Behavioural Neurology 17(2): 105-8, 2006.
  • Hamilton, R.H., Shenton, J.T., Coslett, H.B. An acquired deficit of audiovisual speech processing. Brain and Language 98(1): 66-73, July 2006.
  • Hamilton, R.H., Pascual-Leone, A., Schlaug, G. Absolute pitch in blind musicians. Neuroreport 15(5): 803-6, Apr 2004.
  • Liebeskind, D.S., Wong, S., Hamilton, R.H. Faces of the giant panda and her cub: MRI correlates of Wilson's disease. Journal of Neurology, Neurosurgery & Psychiatry 74(5): 682, May 2003.
  • Keenan, J.P., Freund, S., Hamilton, R.H., Ganis, G., Pascual-Leone, A. Hand response differences in a self-face identification task. Neuropsychologia 38(7): 1047-53, 2000.
  • Van Boven, R.W., Hamilton, R.H., Kauffman, T., Keenan, J.P., Pascual-Leone, A. Tactile spatial resolution in blind braille readers.[see comment]. Neurology 54(12): 2230-6, June 2000.
  • Hamilton, R., Keenan, J.P., Catala, M., Pascual-Leone, A. Alexia for Braille following bilateral occipital stroke in an early blind woman. Neuroreport 11(2): 237-40, Feb 2000.
  • Pascual-Leone, A., Tarazona, F., Keenan, J., Tormos, J.M., Hamilton, R., Catala, M.D. Transcranial magnetic stimulation and neuroplasticity. Neuropsychologia 37(2): 207-17, Feb 1999.

BOOKS & CHAPTERS

  • Kasner, S., Hamilton, R., Messe, S., Prasad, S. Achieving cultural competency: a case-based approach to training health professionals. Hark, L.A., DeLisser, H.M., editors. Chichester: Wiley-Blackwell; 2009. Priya Krishnamurthy: a 73-year-old South Asian Indian woman with a stroke. 89-93p. 
  • Pascual-Leone, A., Hamilton, R. Virtual lesions: examining cortical functions with reversible deactivation. Lomber, S., Gulaske, R., editors. New York: Oxford University Press; 2002. Metamodal cortical processing in the occipital cortex of blind and sighted subjects.
  • Pascual-Leone, A., Hamilton, R., Tormos, J.M., Keenan, J., Catala, M.D. Neuronal plasticity: building a bridge from the laboratory to the clinic. Grafman, J., Christen, Y., editors. New York: Springer Verlag; 1999. Neuroplasticity in the adjustment to blindness. 93-108p.
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