- Jeremy Katzen, MD
Jeremy Katzen, MD
Clinical Instructor, Pulmonary and Critical Care Medicine
Edward J. Stemmler Hall
Philadelphia, PA 19104
Jeremy Katzen, MD, is a Clinical Instructor of Medicine in the Pulmonary, Allergy, and Critical Care Division (PACCD) of the Department of Medicine at the University of Pennsylvania.
Dr. Katzen received his MD in 2011 from University of Rochester School of Medicine and Dentistry, and then completed his internal medicine residency at Northwestern University’s McGaw Medical Center in Chicago, IL in 2014. During this residency and then in a subsequent post-doctoral fellowship year, Dr. Katzen worked in Iasha Sznajder’s lab in Northwestern University’s Division of Pulmonary and Critical Care Medicine. His project explored the role of the Na+/K+ATPase in lung epithelial cell host defense against viral infection. His work identified a novel antiviral function of cardiac glycosides by way of manipulation of intracellular ion flux.
Following his post-doctoral fellowship Dr. Katzen came to Philadelphia for a clinical fellowship in Pulmonary and Critical Care Medicine at the University of Pennsylvania. There he discovered a clinical interest in Interstitial Lung Diseases (ILD) under the mentorship of Dr. Maryl Kreider. Following his clinical fellowship, he joined Dr. Michael Beer’s lab in 2017 and has worked to model human ILD associated mutations in surfactant protein C (SP-C) to understand how challenges to alveolar epithelial proteostasis and quality control drive the development of ILD and lung fibrosis. His work focuses on how alveolar type 2 (AT2) cells stress responses challenge AT2 cell injury repair capacity and lead to pro-fibrotic alveolar niche crosstalk. Additionally, he continued to see patients in his ILD clinic and is a member of the University of Pennsylvania ILD Program
- Medical School-- MD
University of Rochester School of Medicine and Dentistry,
Rochester, NY, 2011
- Internal Medicine Residency
Northwestern University / McGaw Medical Center,
Chicago, IL, 2011-2014
- Postdoctoral Fellowship
Northwestern University Feinberg School of Medicine, Iasha Sznajder Lab
Chicago, IL, 2014-2015
- Pulmonary and Critical Care Medicine Fellowship
Hospital of the University of Pennsylvania,
Philadelphia PA, 2015-2018
- Postdoctoral Fellowship
Pulmonary Biology, Pulmonary and Critical Care Division, University of Pennsylvania, Philadelphia PA, 2018-2019
Research Grants and Contracts
Dr. Katzen is currently funded by the Parker B Francis Fellowship Foundation, the Pulmonary Fibrosis Foundation and Boehringer Ingelheim Pharmaceuticals, the Department of Medicine Measey Fellowship.
- Katzen J, Beers MF. Contributions of alveolar epithelial cell quality control to pulmonary fibrosis. J Clin Invest. 2020 Sep 1; 130, 5088–5099. PMID 32870817 PMCID: PMC7524463.
- Basil MC, Katzen J, Engler AE, Guo M, Herriges MJ, Kathiriya JJ, Windmueller R, Ysasi AB, Zacharias WJ, Chapman HA, Kotton DN, Rock JR, Snoeck HW, Vunjak-Novakovic G, Whitsett JA, Morrisey EE. The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future. Cell Stem Cell. 2020 PMID 32243808 PMCID: PMC7128675.
- Katzen J, Wagner BD, Venosa A, Kopp M, Tomer Y, Russo SJ, Headen AC, Basil MC, Stark JM, Mulugeta S, Deterding RR, Beers MF. An SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis. JCI insight. 2019 PMID: 30721158 PMCID: PMC6483196.
- Alapati D, Zacharias W, Hartman HA, Rossidis AC, Stratigis JD, Ahn NJ, Coons B, Zhou S, Li H, Singh K, Katzen J, Tomer Y, Chadwick AC, Musunuru K, Beers MF, Morrisey EE, Peranteau WH. In utero gene editing for monogenic lung disease. Sci Transl Med. 2019 PMID 30996081 PMCID: PMC6822403.
- Paris AJ, Guo L, Dai N, Katzen JB, Patel PN, Worthen GS, Brenner JS. Using selective lung injury to improve murine models of spatially heterogeneous lung diseases. PLoS One. 2019 PMID 30943189 PMCID: PMC6447173.
- Venosa A, Katzen J, Tomer Y, Kopp M, Jamil S, Russo SJ, Mulugeta S, and Beers MF. Epithelial Expression of an Interstitial Lung Disease–Associated Mutation in Surfactant Protein-C Modulates Recruitment and Activation of Key Myeloid Cell Populations in Mice. J Immuno. 2019 PMID: 30910861 PMCID: PMC6478557
- Hung LY, Sen D, Oniskey TK, Katzen J, Cohen NA, Vaughan AE, Nieves W, Urisman A, Beers MF, Krummel MF, Herbert DR. Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism. Mucosal Immunol 2019. PMID: 30337651 PMCID: PMC6301101.
- Katzen J, Kohn R, Houk JL, Ison MG. Early Oseltamivir After Hospital Admission Is Associated With Shortened Hospitalization: A 5-Year Analysis of Oseltamivir Timing and Clinical Outcomes. Clin Infect Dis. 2019 PMID: 30304487.
- Nureki S-I, Tomer Y, Venosa A, Katzen J, Russo S, Jamil S, Barrett M, Nguyen V, Kopp M, l Mulugeta S, and Beers MF. Expression of mutant Sftpc in murine alveolar epithelia drives spontaneous lung fibrosis. JCI. 2018 PMID: 29920187 PMCID: PMC6118576
- The cell biology of SP-C in health and disease
- Lung epithelial cellular quality control and proteostasis
- Epithelial lung repair and crosstalk in fibrosis and ILD
- Genetic ILD