Perelman School of Medicine at the University of Pennsylvania
The Beers Laboratory
Pulmonary, Allergy, and Critical Care Division of the University of Pennsylvania School of Medicine

University of Pennsylvania / School of Medicine / Beers Lab / Publications


Beers MF, Hawkins A, Shuman H, Zhao M, Newitt JL, Maguire JA, and S Mulugeta.  A novel conserved targeting motif found in ABCA transporters mediates trafficking to early post Golgi compartments. J. Lipid Research 52(8)1471-82 2011.

Beers MF, Hawkins A, Maguire JA, Kotorashvili A, Zhao M, Newitt JL, Ding W, Russo SJ, Guttentag S, Gonzales L, and S Mulugeta.  A non-aggregating Surfactant Protein C mutant is misdirected to early endosomes and disrupts phospholipid recycling.  Traffic  9:1196-1210 2011.

Atochina-Vasserman EN, Bates S, Zhang P,  Abramova H, Zhang Z, Gonzales L,Tao J-Q, Gochuico BR, Gahl W, Guo C-J, Gow AJ, Beers MF, Guttentag SH.  Early Alveolar Epithelial Dysfunction Promotes Lung Inflammation in a mouse model of Hermansky Pudlak Syndrome. Am. J. Resp. Crit. Care Med. 184(4): 449-458 2011. PMID: 21616998.

Maguire JA, Mulugeta S, and MF Beers.  Multiple Ways to Die: Delineation of the Unfolded Protein Response and Apoptosis Induced By Surfactant Protein C BRICHOS Mutants.  Int. J. Biochemistry and Cell Biology  44(1) 101-112   2012   PMID: 22016030.

Maguire JA, Mulugeta S, and Beers MF. Endoplasmic reticulum stress induced by Surfactant Protein C BRICHOS mutants promotes proinflammatory signaling by epithelial cells.  Am J Resp Cell Molecular Biology.  2010 in Press

Kotorashvili A, Russo SJ, Mulugeta S, Guttentag S, and Beers MFAnterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY mediated association with NEDD4 ubiquitin ligases. J. Biological Chemistry 284 (24):16667–678 2009.

Atochina-Vasserman EN, Gow AJ, Abramova H, Guo C-J, Tomer Y, Preston AM, Beck JM, and Beers MF  Immune Reconstitution During Pneumocystis Lung Infection: Disruption of Surfactant Component Expression and Function by S-Nitrosylation. J.Immunol. 182: 2277–87 2009.

Guo CJ, Atochina-Vasserman EN, Abramova E,. Foley JP, Zaman A, Crouch EC, Beers MF, Savani  RC, and Gow AJ.  S-Nitrosylation of Surfactant Protein D controls inflammatory cell function.  PLoS  Biology 6(11): e266.  2008.

Jain D, Atochina-Vasserman EN, Tomer Y,  Kadire H and Beers MF.  Surfactant Protein D Protects Against Acute Hyperoxic Lung Injury. Am J Resp Crit. Care Med. 178: 805-813 2008.

Atochina-Vasserman EN, Beers MF, Kadire H, Tomer Y, Inch A, Scott P, Guo CJ, and Gow AJ. Selective Inhibition of iNOS Activity in Vivo Reverses Inflammatory Abnormalities in SP-D Deficient Mice. J. Immunology  17: 8090-8097  2007.

Mulugeta S, Maguire JA, Russo SJ, Kotorashvili A, Newitt J, and MF BeersMisfolded BRICHOS SP-C mutant proteins induce apoptosis via caspase 4 and cytochrome c related mechanisms.  Am. J. Physiol: Lung Cell Mol Physiol. 293: L720-L729.

Casey J, Kaplan J, Atochina-Vasserman EN, Gow AJ, Kadire H, Tomer Y, Fisher JH, Hawgood S, Savani RC and Beers MF. Alveolar Surfactant Protein D Content Modulates Bleomycin Induced Lung Injury. Am J Resp Critical Care Medicine 172: 869-877 2005.

Beers MF and Mulugeta S. Surfactant Protein C biosynthesis and its emerging role in conformational lung disease. Annual Review Physiology 67: 663-696 2005.

Mulugeta S, Nguyen V, Russo SJ, Muniswamy M and Beers MF. A ProSP-C BRICHOS Domain Mutation Causes ER Stress, Proteasome Dysfunction, and Caspase 3 Activation. Am J Resp Cell Mol Biol. 32: 521-530 2005.

Stevens PA, Pettenazzo A, Baritussio A, Mulugeta S, Brasch F, Ochs M, Russo SJ, Morrison L and Beers MF. Non-Specific Interstitial Pneumonitis, Alveolar Proteinosis, and Abnormal Proprotein Trafficking in a Patient With a Novel Spontaneous Mutation in Surfactant Protein C Gene. Pediatric Research 57: 89-98 2005.

Atochina EN, Beck JM, Preston AM, Haczku A, Tomer Y, Scanlon ST, Fusaro T, Casey J, Hawgood S, Gow AJ and Beers MF. Enhanced Lung Injury And Delayed Clearance of Pneumocystis In Surfactant Protein A Deficient Mice. Infect. and Immun. 72: 6002-11 2004.

Atochina EN, Gow AJ, Beck JM, Haczku A, Inch A, Kadire H, Davis C, Preston AM, Poulain F, Hawgood S and Beers MF. Surfactant Protein D deficient mice exhibit delayed early clearance of Pneumocystis lung infection with increased inflammation and nitric oxide intermediates. Journal of Infectious Diseases 189: 1528-39 2004.

Hamvas A, Nogee LN, White FV, Schuler P, Hackett BP, Huddleston CB, Mendeloff EN, Hsu FF, Wert SE, Gonzales LW, Beers MF and PL Ballard. Progressive lung disease and surfactant dysfunction with a deletion of surfactant protein C gene. Am J Resp Cell Mol. Biol. 30: 771-776 2004.

Brasch F, Griese M, Tredano M, Johnen G, Ochs M, Nicolai T, Rieger C, Hawgood S, Mulugeta S, Müller KM , Bahuau M and Beers MF. Interstitial lung disease in a baby with a de novo mutation of the SFTPC gene. European Respiratory Journal 24 (1): 30-39 2004.

Mulugeta S and Beers MF. Processing of Surfactant Protein C Requires a Type II Transmembrane Topology Directed by Juxtamembrane Positively Charged Residues. J Biol Chemistry 278 (48): 47979-47986 2003.

Wang W-J, Mulugeta S, Russo SJ and Beers MF. Deletion Of Exon 4 From Human Surfactant Protein C Results In Aggresome Formation and Generation of a Dominant Negative. J Cell Science 116 (4): 683-692 2003.

Wang W-J, Russo SJ, Mulugeta S and Beers MF. Biosynthesis of surfactant protein C: Sorting of SP-C proprotein involves oligomeric association via a signal anchor domain. J Biol Chem 277: 19929-19937 2002.

Johnson AL, Braidotti P, Pietra GG, Russo SJ, Kabore A, Wang W-J and Beers MF. Post-translational processing of SP-C proprotein: Targeting motifs in the NH2 flanking domain are cleaved in late compartments. Am J. Resp Cell Mol Biol. 24: 253-263 2001.

Kabore AF, Wang W-J, Russo SJ and Beers MF. Biosynthesis of surfactant protein C: Characterization of aggresome formation By EGFP chimeras containing propeptide mutants lacking conserved cysteine residues. J. Cell Science 114 (2): 293-302 2001.




MF Beers

Michael F. Beers, M.D.
Lab Director