While ex vivo activation of T cells is often accomplished using TCR and costimulatory receptor ligands immobilized on polystyrene plastic, T cells normally interact with antigen presenting cells such as dendritic cells that display complex surface topology and cytoskeletal rigidity.  We are exploring how modifying the surface topology, ligand patterning and mechanical properties of the materials used for activation can influence T cell expansion and differentiation.

These studies are being carried out as part of a multiple investigator research consortium funded by the NIH Nanomedicine Initiative.  There are several projects available in this area.