Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Qin Laboratory

Publications

1. Altman, A.R., de Bakker, C.M.J., Chandra, A., Huh, B.K., Luo, S., Leonard, M.B., Qin, L., and Liu, X.S. Quantification of skeletal growth, modeling, and remodeling by in vivo micro computed tomography. Bone, in press.

2. de Bakker, C.M.J., Altman, A.R., Tseng, W., Tribble, M.B., Li, C., Chandra, A., Qin, L., and Liu, X.S.µCT-Based, in vivo dynamic bone histomorphometry allows 3D evaluation of the early responses of bone resorption and formation to PTH and Alendronate combination therapy. (2015) Bone 73: 198-207.

3. Li, Q., Doyran, B., Gamer, L.W., Lu, X.L., Qin, L., Ortiz, C., Grodzinsky, A.J., Rosen, V., and Han, L. Biomechanical properties of murine meniscus surfaces via AFM-based nanoindentation. (2015) J. Biomech. 48: 1364-1370.

4. Scanzello, C.R., Markova, D.Z., Chee, A., Xiu, Y., Adams, S.L., Anderson, G., Zgonis, M., Qin, L., An, H.S., and Zhang, Y. Fibronectin splice variation in human knee cartilage, meniscus and synovial membrane: observations in osteoarthritic knee. (2015) J. Orthop. Res. 33: 556-562.

5. Chandra, A., Lin, T., Zhu, J., Tong, W., Huo, Y., Jia, H., Zhang, Y., Liu, X.S., Cengel, K., Xia, B., and Qin, L. PTH1-34 blocks radiation-induced osteoblast apoptosis by enhancing DNA repair through canonical Wnt pathway. (2015) J. Biol. Chem. 290: 157-167.

6. Altman A.R., de Bakker C.M.J., Tseng, W., Chandra, A., Qin, L., and Liu, X.S. Enhanced individual trabecular repair and its mechanical implications in PTH and alendronate treated rat tibial bone. (2015) J. Biomech. Eng. 137.

7. Chandra, A., Lin, T., Tribble, M., Zhu, J., Altman, A.R., Tseng, W., Zhang, Y., Akintoye, S.O., Cengel, K., Liu, X.S., and Qin, L. PTH1-34 alleviates radiotherapy-induced local bone loss by improving osteoblast and osteocyte survival. (2014) Bone 67: 33-40.

8. Zhang, X., Zhu, J., Liu, F., Li, Y., Chandra, A., Levin, L.S., Beier, F., Enomoto-Iwamoto, M., and Qin, L. Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model. (2014) Bone Research. 2: 14015.

9. Altman, A.R., de Bakker, C.M.J., Tseng, W., Huh, B.K., Chandra, A., Qin, L., and Liu, X.S. A closer look at the immediate trabecular response to combined parathyroid hormone and alendronate treatment. (2014) Bone 61: 149-157.

10. Zhang, X., Zhu, J., Li, Y., Lin, T., Siclari, V.A., Chandra, A., Candela, E.M., Koyama, E., Enomoto-Iwamoto, M., and Qin, L. Epidermal growth factor receptor (EGFR) signaling regulates epiphyseal cartilage development through beta-catenin-dependent and -independent pathways. (2013) J. Biol. Chem. 288: 32229-32240.

11. Chandra, A., Lan, S., Zhu, J., Siclari, V., and Qin. L. Epidermal growth factor receptor (EGFR) signaling promotes proliferation and survival in osteoprogenitors by increasing early growth response protein (Egr2) expression. (2013) J. Biol. Chem. 288: 20488-20498.

12. Lan, S., Luo, S., Huh, B., Chandra, A., Altman, A.R., Qin, L., and Liu, X.S. 3D image registration is critical to ensure accurate detection of longitudinal changes in trabecular bone density, microstructure, and stiffness measurements in rat tibiae by in vivo micro computed tomography (µCT). (2013) Bone 56: 83-90.

13. Chandra, A., Lan, S., Zhu, J., Lin, T., Zhang, X., Siclari, V.A., Altman, A.R., Cengel, K.A., Liu, X.S., and Qin, L. PTH prevents the adverse effects of focal radiation on bone architecture in young rats. (2013) Bone 55: 449-457.

14. Barnes, V.M., Xu, T., Shimizu, E., Nakatani, T., Jefcoat, S., Vasilov, A, Qin, L., and Partridge, N.C. Triclosan blocks Mmp 13 expression in hormone-stimulated osteoblasts. (2013) J Periodontol. 84: 1683-1689.

15. Siclari, V.A., Zhu, J., Akiyama, K., Liu, F., Zhang, X., Chandra, A., Nah, H., Shi, S., and Qin, L. Mesenchymal progenitors residing close to the bone surface are functionally distinct from those in the central bone marrow. (2013) Bone 53: 575-586.

16. Cantley, L., Saunders, C., Guttenberg, M., Candela, M.E., Ohta, Y., Yasuhara, R., Kondo, N., Sgariglia, F., Asai, S., Hugel, J., Zhang, X., Qin, L., Hecht, J.T., Chen, D., Yamatomto, M., Toyosawa, S., Dormans, J.P., Esko, J.D., Yamaguchi, Y., Iwamoto, M., Pacifici, M., and Enomoto-Iwamoto. Loss of β-Catenin induces multifocal periosteal chondroma-like masses in mice. (2013) Am. J. Pathol. 182: 917-927.

17. Zhu, J., Siclari, V.A., Liu, F., Spatz, J.M., Chandra, A., Divieti Pajevic, P., and Qin, L. Amphiregulin-EGFR signaling mediates the migration of bone marrow mesenchymal progenitors toward PTH-stimulated osteoblasts and osteocytes. (2012) PLoS ONE 7: e50099.

18. Usmani, S.E., Pest, M.A., Kim, G., Ohora, S.N., Qin, L., and Beier, F. Transforming growth factor alpha controls the transition from hypertrophic cartilage to bone during endochondral bone growth. (2012) Bone 51: 131-141.

19. Moorthi, A., Saravanan, S., Srinivasan, N., Partridge, N.C., Zhu, J., Qin, L., and Selvamurugan, N. Synthesis, characterization and biological action of nano-bioglass ceramic particles for bone formation. (2012) J. Biomaterials and Tissue Engineering 2: 197-205.

20. Zhang, X., Siclari, V.A., Lan, S., Zhu, J., Koyama, E., Dupuis, H.L., Enomoto-Iwamoto, M., Beier, F., and Qin, L. The critical role of the epidermal growth factor receptor in endochondral ossification. (2011) J. Bone Miner. Res. 26: 2622-2633.

21. Zhu, J., Shimizu, E., Zhang, X., Partridge, N.C., and Qin, L. EGFR signaling suppresses osteoblast differentiation and inhibits expression of master osteoblastic transcription factors Runx2 and Osterix. (2011) J. Cell. Biochem. 112: 1749-1760.

22. Zhang, X., Tamasi, J., Lu, X., Zhu, J., Chen, H., Tian, X., Lee, T., Threadgill, D.W., Kream, B.E., Kang, Y., Partridge, N.C. and Qin, L. Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo. (2011) J. Bone Miner. Res. 26: 1022-1034.

Research Publications, Peer-reviewed Reviews

1. Siclari, V.A. and Qin, L. (2010) Targeting the osteosarcoma cancer stem cells. J. Orthop. Surg. Res.; 5: 78.

Book chapters

1. Zhu, J., Siclari, V.A. and Qin, L. (2014) Isolating endosteal mesenchymal progenitors from rodent long bones. Invited chapter in “Osteoporosis and Osteoarthritis, Methods in Molecular Biology”, Vol. 1226, Edited by Westendorf and van Wijnen, Springer, 19-29.

2. Qin, L. & Partridge, N.C. (2012) Parathyroid hormone and parathyroid hormone-related protein: normal function, diseases, and emerging therapeutics. Invited chapter in “Bone-Metabolic Functions and Modulators (Topics in Bone Biology)” Vol. 7, Edited by Bronner, Farach-Carson, and Roach. Springer, 1-20.

 

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