Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Qin Laboratory


Chandra A, Lin T, Zhu J, Wei T, Huo Y, Jia H, Zhang Y, Liu XS, Cengel K, Xia B, Qin L.:PTH1-34 Blocks Radiation-Induced Osteoblast Apoptosis by Enhancing DNA Repair through Canonical Wnt Pathway.J Biol Chem. 2014 Oct 21. pii: jbc.M114.608158. [Epub ahead of print]

Zhang X, Zhu J, Liu F, Li Y, Chandra A, Levin L.S, Beier F, Enomoto-Iwamoto M,Qin L.:Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model. Bone Research 2, Article number: 14015 (2014) ​doi:10.1038/boneres.2014.15

Altman A, de Bakker CM, Tseng WJ, Chandra A, Qin L, Liu X. :Enhanced Individual Trabecular Repair and Its Mechanical Implications in PTH and Alendronate Treated Rat Tibial Bone.J Biomech Eng. 2014 Oct 1. doi: 10.1115/1.4028823. [Epub ahead of print]

Scanzello CR, Markova DZ, Chee A, Xiu Y, Adams SL, Anderson G, Zgonis M, Qin L, An HS, Zhang Y. :Fibronectin Splice Variation in Human Knee Cartilage, Meniscus and Synovial Membrane: Observations in Osteoarthritic Knee.J Orthop Res. 2014 Nov 20. doi: 10.1002/jor.22787. [Epub ahead of print]

Zhu J, Siclari VA, Qin L. :Isolating endosteal mesenchymal progenitors from rodent long bones. Methods Mol Biol. 2015;1226:19-29.

Chandra A, Lin T, Tribble MB, Zhu J, Altman AR, Tseng WJ, Zhang Y, Akintoye SO, Cengel K, Liu XS, Qin L. :PTH1-34 alleviates radiotherapy-induced local bone loss by improving osteoblast and osteocyte survival.Bone. 2014 Oct;67:33-40.

Altman AR, Tseng WJ, de Bakker CM, Huh BK, Chandra A,Qin, L., Liu, X.S.: A closer look at the immediate trabecula response to combined parathyroid hormone and alendronate treatment.Bone. 2014 Jan 24;61:149-157.

Lan, S., Luo, S., Huh, B., Chandra, A., Altman, A.R., Qin, L., Liu, X.S.: 3D image registration is critical to ensure accurate detection of longitudinal changes in trabecular bone density, microstructure, and stiffness measurements in rat tibiae by in vivo micro computed tomography (µCT). Bone 56: 83-90, 2013

Cantley, L., Saunders, C., Guttenberg, M., Candela, M.E., Ohta, Y., Yasuhara, R., Kondo, N., Sgariglia, F., Asai, S., Hugel, J., Zhang, X., Qin, L., Hecht, J.T., Chen, D., Yamatomto, M., Toyosawa, S., Dormans, J.P., Esko, J.D., Yamaguchi, Y., Iwamoto, M., Pacifici, M., and Enomoto-Iwamoto. : Loss of β-Catenin induces multifocal periosteal chondroma-like masses in mice. Am. J. Pathol. 182: 917-927, 2013.

Siclari, V.A., Zhu, J., Akiyama, K., Liu, F., Zhang, X., Chandra, A., Nah, H., Shi, S., and Qin, L.: Mesenchymal progenitors residing close to the bone surface are functionally distinct from those in the central bone marrow. Bone 53: 575-586, 2013.

Zhang, X., Zhu, J., Li, Y., Lin, T., Siclari, V.A., Chandra, A., Candela, E.M., Koyama, E., Enomoto-Iwamoto, M., and Qin, L. : Epidermal growth factor receptor (EGFR) signaling regulates epiphyseal cartilage development through beta-catenin-dependent and -independent pathways. J. Biol. Chem. 288: 32229-32240, 2013.

Chandra, A., Lan, S., Zhu, J., Siclari, V., and Qin. L.: Epidermal growth factor receptor (EGFR) signaling promotes proliferation and survival in osteoprogenitors by increasing early growth response protein (Egr2) expression. J. Biol. Chem. 288: 20488-20498, 2013.

Chandra, A., Lan, S., Zhu, J., Lin, T., Zhang, X., Siclari, V.A., Altman, A.R., Cengel, K.A., Liu, X.S., and Qin, L. : PTH prevents the adverse effects of focal radiation on bone architecture in young rats. Bone 55: 449-457, 2013.

Barnes, V.M., Xu, T., Shimizu, E., Nakatani, T., Jefcoat, S., Vasilov, A, Qin, L., and Partridge, N.C. : Triclosan blocks Mmp 13 expression in hormone-stimulated osteoblasts. J. Periodontol. 84: 1683-1689, 2013.

Zhu, J., Siclari, V.A., Liu, F., Spatz, J.M., Chandra, A., Divieti Pajevic, P., and Qin, L. : Amphiregulin-EGFR signaling mediates the migration of bone marrow mesenchymal progenitors toward PTH-stimulated osteoblasts and osteocytes. PLoS ONE Page: e50099, Dec 2012.

Moorthi, A., Saravanan, S., Srinivasan, N., Partridge, N.C., Zhu, J., Qin, L., and Selvamurugan, N. : Synthesis, characterization and biological action of nano-bioglass ceramic particles for bone formation. J. Biomaterials and Tissue Engineering 2: 197-205, Sept 2012.