Publications | Penn Brain Tumor Center | Perelman School of Medicine at the University of Pennsylvania

Generation of Allogeneic CAR-T Circumvents Functional Deficits in Patient-Derived Autologous Product for Glioblastoma.

International journal of cancer. 2026 Sep 15;159(6):1521-1534 Epub 2026 Apr 24;

Authors: Salim SK, Shaikh MV, Wei J, Maich WT, Anand A, Tang OY, Subapanditha MK, Alizada Z, Suk Y, Singh M, Zhai K, Khanna A, Brakel B, Dimitrov V, Tabunshchyk Z, Chan K, Brown KR, Vora P, O'Rourke DM, Binder ZA, Venugopal C, Moffat J, Singh SK

Predicting future cognitive impairment in preclinical Alzheimer's disease using amyloid PET and MRI: A multisite machine learning study.

Neurobiology of aging. 2026 Sep;165:8-23 Epub 2026 Apr 19;

Authors: Yang B, Earnest T, Bilgel M, Albert MS, Johnson SC, Davatzikos C, Erus G, Masters CL, Resnick SM, Miller MI, Bakker A, Morris JC, Benzinger TLS, Gordon BA, Sotiras A, Alzheimer’s Disease Neuroimaging Initiative, Preclinical Alzheimer’s Disease Consortium

Histone H3K27M variants determine myeloid subset dependencies and immune reprogramming in diffuse midline glioma.

Proceedings of the National Academy of Sciences of the United States of America. 2026 Aug 18;123(33):e2537768123 Epub 2026 Aug 13;

Authors: Puigdelloses Vallcorba M, Rawat K, Soni N, DiMauro A, Chu JD, Thomason W, Furtado GC, Strahl M, Wu J, Joshi T, Angione A, Piñero G, Becher OJ, Ross JL, Tsankov AM, Lira SA, Hambardzumyan D

Computed tomography- and magnetic resonance imaging-visible, patient-specific canine head phantom via 3-dimensional anatomy printing for neurosurgical training and biopsy planning: a proof of concept.

American journal of veterinary research. 2026 Aug 12;:1-10;

Authors: Kessel RM, Nidhi Bhati A, Yu Y, Roney JN, Gupta R, Amankulor NM, Mai W, Dasari M, Mangharam R, Panek WK

Depletion of CARM1 slows in vivo tumorigenicity and rewires developmental programming in glioma stem-like cells.

Cell reports. 2026 Aug 7;45(8):117785;

Authors: Young DL, Stransky S, Molero MG, Yamashita E, Pande S, Kumar V, Singh S, Aguilan J, Cutler R, Koba W, DeAngelo JD, Roth JS, Zhang J, He T, Malachowska B, Vercellino J, Bell BI, Shechter D, Tofilon PJ, Phillips RE, Behnan J, Guha C, Sidoli S

(18)F-Fluciclovine for Detection of Recurrent Brain Metastases After Radiation Therapy: Image Interpretation Criteria and Diagnostic Performance From the PURSUE Study.

International journal of radiation oncology, biology, physics. 2026 Aug 1;125(5):1410-1420 Epub 2026 Feb 26;

Authors: Kotecha R, Chiang V, Tom MC, Parent E, Nabavizadeh A, Siegel BA, Huang J, Zan E, Peddi S, Brem S, Ware M, Sulman EP, Kesari S, Pope W, Holmes R, Chau A, Teoh EJ, Chao ST, Aboian M, PURSUE Study Group

Expanding the molecular grading criteria in IDH-mutant astrocytoma.

Neuro-oncology. 2026 Aug 1;28(8):1921-1932;

Authors: Virata MC, Samanamud J, Slocum CC, Kandoi S, Nguyen P, Savani MR, Shi DD, Sharma S, Hiya S, Maldonado-Díaz C, Clare K, Yokoda RT, Vij M, Mir E, Nishikawa Y, Umphlett M, Yong RL, Bederson JB, Silva-Hurtado TJ, Brem S, Hambardzumyan D, Snuderl M, Viapiano MS, Abdullah KG, McBrayer SK, Hatanpaa KJ, Walker JM, Tsankova NM, Richardson TE

Impaired intrinsic motivation in psychosis risk relates to ventral striatum activation to self-generated reinforcement signals.

Schizophrenia research. 2026 Aug;294:7-16 Epub 2026 Apr 16;

Authors: Prettyman GE, Kales E, Didier P, Savage C, Levinson T, Rosenbaum S, de Moraes Leme LFV, Kable JW, Moore TM, Satterthwaite TD, Davatzikos C, Shinohara RT, Elliott MA, Kohler CG, Gur RC, Gur RE, Calkins ME, Wolf DH

Modeling gliomas with organoids: Classification, fidelity, and guidelines for translational neuro-oncology.

Neuro-oncology. 2026 Aug 1;28(8):1861-1876;

Authors: Hubert CG, Read RD, Miller TE, Kim U, Wang X, Ishan M, Wang Z, Miller EZY, Sun Y, Lai A, Ming GL, Song H, Wang Z

Tooth loss is associated with subsequent brain white matter degradation up to over a decade.

Journal of dentistry. 2026 Aug;171:106732 Epub 2026 May 2;

Authors: Tian Q, Qi X, Greig EE, Landman BA, Davatzikos C, Resnick SM, Wu B, Ferrucci L

Author Correction: Sleep chart of biological ageing clocks in middle and late life.

Nature. 2026 Jul 30;

Authors: MULTI Consortium, O'Toole CK, Song Z, Anagnostakis F, Yang Z, Tian YE, Duggan MR, Zou C, Leng Y, Cai Y, Bai W, Fu CHY, Rafii MS, Aisen P, Wang G, De Jager PL, Zeng J, Oh HS, Zhou X, Walker KA, Belsky DW, Zalesky A, Simonsick EM, Resnick SM, Ferrucci L, Davatzikos C, Wen J

Molecular Brain Tumor Imaging Beyond [(18)F]FDG: Somatostatin Receptor PET, Amino Acid PET, and Emerging Applications-From the AJR Special Series on Molecular Imaging.

AJR. American journal of roentgenology. 2026 Jul 29;

Authors: Kuhn A, Marulanda-Corzo V, Gardella J, Vu KV, Matesva M, Coraci S, Nabavizadeh A, Barajas RF Jr, Ivanidze J

Uncertainty-Aware Risk Stratification in Pediatric Low-Grade Glioma Using Multimodal Data.

AJNR. American journal of neuroradiology. 2026 Jul 29;

Authors: Batal F, Vunnava B, Kraya A, Gandhi D, Familiar A, Rathi K, Varshochi S, Chrysochoou D, Rezaei S, Farah O, Kollur A, Blatney A, Madsen P, Storm PB, Resnick A, Vossough A, Nabavizadeh A, Kazerooni AF

Immunotherapy for Diffuse Midline Glioma: From Preclinical Modeling to Clinical Translation.

Cancers. 2026 Jul 27;18(15);

Authors: Kordowski A, Pomaville M, Foster JB, Vitanza NA

Cochlear implants are associated with reduced cognitive decline risk: A 20-year cohort study.

Alzheimer's & dementia (Amsterdam, Netherlands). 2026 Jul-Sep;18(3):e70409 Epub 2026 Jul 24;

Authors: Anagnostakis F, Kokkorakis M, Papadimopoulos I, Wen J, Davatzikos C

CLEAR: an auditable foundation model for radiology grounded in clinical concepts.

Nature biomedical engineering. 2026 Jul 22;

Authors: Han T, Wu R, Tian Y, Khader F, Adams LC, Bressem KK, Davatzikos C, Kather JN, Shen L, Mankoff DA, Barbosa EM Jr, Truhn D

Validation of proposed cIMPACT-NOW update 12 molecular grading criteria for IDH-mutant astrocytoma.

Acta neuropathologica. 2026 Jul 22;152(1);

Authors: Richardson TE, Samanamud J, Virata MC, Mir E, Kandoi S, Slocum CC, Shi DD, Savani MR, Yokoda RT, Sharma S, Yong RL, Bederson JB, Silva-Hurtado TJ, Nguyen P, Hiya S, Maldonado-Díaz C, Clare K, Vij M, Nishikawa Y, Umphlett M, Hatanpaa KJ, Brem S, Viapiano MS, Snuderl M, Hambardzumyan D, Walker JM, Abdullah KG, McBrayer SK, Tsankova NM

Early increase in apparent diffusion coefficient predicts favorable response to Dordaviprone (ONC201) therapy in H3K27M-mutant diffuse midline glioma.

Neuro-oncology. 2026 Jul 21;

Authors: Lau BC, Ajaero DP, Hoff BA, Pearson A, Sajjakulnukit P, Wadden J, Adam T, Ji S, Green AL, Nabavizadeh A, Cao Y, Aryal M, Upadhyaya S, Franson A, Galban S, Venneti S, Federowicz B, Shapiro MA, Stuhlmiller TJ, Lyssiotis C, Galban CJ, Parmar HA, Ibrahim M, Koschmann C

Balloon-assisted retrograde cerebral venography for enhanced visualization of the posterior and lateral dural venous sinuses: a feasibility study.

Neuroradiology. 2026 Jul 10;

Authors: Ahmed W, Gandhi OH, Almasri S, Alkhatib SG, Freeman C, Mohan S, Bagley LJ, Singh A, Yu N, Tierradentro-Garcia LO, Wakhloo AK, Choudhri OA

Neuroradiology Leads NIH Funding Among Clinician Diagnostic Radiologists: A 14-Year National Analysis.

AJNR. American journal of neuroradiology. 2026 Jul 4;

Authors: Gomez PT, Kandala K, Moily R, Futela D, Payabvash S, Lakhani DA, Mohan S, Vagal A, Wintermark M, Gandhi D, Malhotra A

Hypofractionated Proton Reirradiation for Recurrent Glioblastoma: Clinical and Dosimetric Outcomes from a Large Single Institution Series.

International journal of radiation oncology, biology, physics. 2026 Jul 2;

Authors: Linkowski L, Messing I, Berger M, Hollawell C, Friedes C, Alexander D, Wang X, Desai AS, Phillips RE, O'Rourke DM, Amankulor NM, Jackson C, Hubbeling H, Kurtz G, Bagley SJ, Bradley JD, Mohan S, Alonso-Basanta M, Lebow ES

Artificial intelligence analysis of temporalis muscle thickness for monitoring sarcopenia and clinical outcomes in individuals with paediatric brain tumours: a retrospective cohort study.

The Lancet. Digital health. 2026 Jul;8(7):100973 Epub 2026 May 27;

Authors: Zapaishchykova A, Zielke J, Tak D, Climent Pardo JC, Mojahed-Yazdi R, Soto-Rivera CL, Liu KX, Saraf A, Ye Z, Wang W, Chen YH, Vajapeyam S, Mak RH, Mueller S, Nabavizadeh A, Wilson RL, Dieli-Conwright CM, Ligon KL, Haas-Kogan DA, Aerts HJWL, Poussaint TY, Benitez V, Chi SN, Kann BH

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association. 2026 Jul;22(7):e71630;

Authors: Lorenz AS, Sathe A, Yang Y, Durant A, Wu Y, Kim ME, Gao C, Newlin NR, Ramadass K, Kanakaraj P, Khairi NM, Li Z, Yao T, Huo Y, Dumitrescu L, Shashikumar N, Pechman KR, Risacher SL, Beason-Held LL, An Y, Arfanakis K, Erus G, Davatzikos C, Habes M, Wang D, Tosun D, Toga AW, Thompson PM, Mormino EC, Zhang P, Schilling K, Albert M, Kukull W, Biber SA, Landman BA, Johnson SC, Bendlin B, Schneider J, Bennett DA, Jefferson AL, Resnick SM, Saykin AJ, Below JE, Hohman TJ, Archer DB, Alzheimer's Disease Neuroimaging Initiative (ADNI), BIOCARD Study Team (BIOCARD), Alzheimer's Disease Sequencing Project (ADSP)

Association of sleep duration with Alzheimer's disease and cognition.

Alzheimer's & dementia : the journal of the Alzheimer's Association. 2026 Jul;22(7):e71528;

Authors: Anagnostakis F, O'Toole CK, Erus G, Srinivasan D, Cui Y, Kokkorakis M, Ma X, Reitz C, Brickman AM, Kontos D, Gupta A, Payabvash S, Konofagou EE, McIlvain G, Cheng F, Baldwin MR, Shou H, Davatzikos C, Resnick S, Wen J

Anti-LAG-3 with or without anti-PD-1 in recurrent glioblastoma: a phase 1 trial.

Nature medicine. 2026 Jul;32(7):2449-2460 Epub 2026 Jul 10;

Authors: Lim M, Ye X, Piotrowski AF, Desai A, Ahluwalia MS, Walbert T, Lesser G, Ellingson BM, Peereboom DM, Fisher JD, Desideri S, Jackson C, Pant A, Jain A, Verma R, Oberlton B, Piyadasa H, Bettegowda C, Engle L, Taube J, Bendall SC, Choi J, Drappatz J, Lieberman FS, Kleinberg LR, Pardoll DM, Nabors LB, Wen PY, Grossman SA

Minimal Clinically Important Difference of the Sinonasal Outcome Test in Sinonasal Malignancy.

The Annals of otology, rhinology, and laryngology. 2026 Jul;135(7):543-549 Epub 2026 Mar 25;

Authors: Maoz SL, Lee M, Fischer JL, Choby G, Hwang PH, Wang EW, Kuan EC, Adappa ND, Geltzeiler M, Getz AE, Humphreys IM, Le CH, Pinheiro-Neto CD, Chan EP, Roozdar P, Abuzeid WM, Chang EH, Jafari A, Kingdom TT, Kohanski MA, Lee JT, Lazor J, Nabavizadeh A, Nayak JV, Palmer JN, Patel ZM, Resnick AC, Smith TL, Snyderman CH, St John MA, Storm PB, Suh JD, Wang MB, Sim MS, Beswick DM

Feasibility and Safety of High-Dose Proton Re-Irradiation in Recurrent Pediatric Central Nervous System Tumors: A Single-Institution Retrospective Study.

Pediatric blood & cancer. 2026 Jul;73(7):e70371 Epub 2026 May 4;

Authors: Song JH, Baron J, Perez CC, Ramesh S, Minturn J, Desai KA, Shah AC, Belasco JM, Cole KA, Fisher MJ, Storm PB, Madsen PM, Kurtz G, Lustig RA, Hill-Kayser C, LaRiviere MJ

Exploring the structural lexicon of the Proteome via Metric Geometry.

PLoS computational biology. 2026 Jun;22(6):e1014487 Epub 2026 Jun 30;

Authors: Gunther E, Camara PG

mRNA CAR T cells promote tolerable, tunable therapy in preclinical high grade glioma models.

Molecular therapy. Oncology. 2026 Sep 17;34(3):201273 Epub 2026 Jun 30;

Authors: Pomaville M, Foster JB

Neurophysiological Correlates of Neuroanatomical Dimensions in Major Depressive Disorder: Electroencephalographic Markers of Brain Function and Treatment Outcome.

Biological psychiatry global open science. 2026 Sep;6(5):100750 Epub 2026 May 7;

Authors: Xiao W, Woodham RD, Antoniades M, Srinivasan D, Fan Y, Erus G, Garcia JA, Arnott SR, Chen T, Choi KS, Chin Fatt CR, Frey BN, Farzan F, Frøkjær VG, Ganz M, Godlewska BR, Hassel S, Ho K, McIntosh AM, Qin K, Rotzinger S, Sacchet MD, Savitz J, Shou H, Singh A, Stolicyn A, Strigo I, Strother SC, Tosun D, Wei D, Zahn R, Anderson IM, Craighead WE, Deakin JFW, Dunlop BW, Elliott R, Gong Q, Gotlib IH, Harmer CJ, Kennedy SH, Knudsen GM, Mayberg HS, Paulus MP, Qiu J, Trivedi MH, Whalley HC, Yan CG, Young AH, Davatzikos C, Fu CHY