Microbiome Research at Penn and CHOP

gnotobioticcoreimageThe PennCHOP Microbiome Program supports research across a wide spectrum of topics, with the goal of devising methods for improving human health by manipulating microbial populations.  Teams at UPenn and CHOP were leaders in the Human Microbiome Project, the largest project in the history of microbiology.  Studies are now expanding to link up microbiome research with myriad diverse areas of basic, translational and clinical research.

Microbiome research at Penn and CHOP includes analysis of multiple human body sites including gut, airway and skin.  Microbiome studies have also been carried out extensively using animal models, including germ free (gnotobiotic) mice.  Additional ongoing projects seek to translate insights in microbiome analytical methods to clinical diagnosis.

Recent progress is summarized in our published papers


Annual PennCHOP Microbiome Pilot & Feasibility Projects

Each year the PennCHOP Microbiome Program matches with various partners to fund new and exciting research in the microbiome.

Please click here to see a list of 2017's selected projects, and here to see a partial listing of the 2016 projects.  


Ongoing microbiome research projects:

"Transfer: Dissecting the interplay of MCH/HLA loci, the microbiota and autoimmune diabetes"
Michael Silverman, MD/PhD ; Children's Hospital of Philadelphia 
Funded by: National Institutes of Health

‚ÄúLongitudinal analysis of respiratory tract microbiome change and sequence-based infection diagnosis during mechanical ventilation‚ÄĚ
Brendan Kelly, MD; University of Pennsylvania (NIH)
Funded by: National Institutes of Health

"Role of Bacterial Urease in Host and Gut Microbiota Amino Acid Metabolism"
David Shen MD/PhD; University of Pennsylvania
Funded by: American Gastroenterological Association

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