PennPORT
Jenna Karras
Department of Psychiatry,
University of Pennsylvania
Education:
| 2010 |
B.S. Biology – University of Wisconsin, Eau-Claire, WI |
|
2016 |
Ph.D. Molecular, Cellular and Developmental Biology – The Ohio State University, Columbus, OH |
|
2017-Present |
PennPORT fellow, Immunology, Microenvironment and Metastasis Program, University of Pennsylvania |
Research Mentor: Erica Stone, Ph.D.; The Wistar Institute
Research Topic: Effect of altered mucosal glycosylation patterns on oral tolerance and cancer progression. My research interests focus primarily on how downregulation of the glycosylation enzyme C2GNT2, which generates branched O-glycans in the gut, alters immune response and leads to progression of colorectal cancer.
Teaching Interests: Molecular Biology, Cancer Biology, Microbiology, Immunotherapy
Publications:
Karras JR*, Schrock MS*, Batar B*, Huebner K. Fragile genes that are frequently altered in cancer: players not passengers. Cytogenetic Genome Research. 2017.
Kiss DL, Waters CE, Ouda IM*, Saldivar JC, Karras JR, Amin ZA, Mahrous S, Druck T, Bundschuh RA, Schoenberg DR, Huebner K. Identification of Fhit as a post-transcriptional effector of Thymidine Kinase 1 expression. BBA-Gene Regulatory Mechanisms. 2017.
Schrock MS, Karras JR, Guggenbiller MJ, Druck T, Batar B, Huebner K. Fhit and Wwox lossassociated genome instability: A genome caretaker one-two punch. Adv in Biol Regulation. 2016.
Karras JR, Schrock MS, Batar B, Zhang J, La Perle K, Druck T, Huebner K. Fhit loss associated initiation and progression of neoplasia in vitro. Cancer Science. 2016.
Paisie CA, Schrock MS, Karras JR, Zhang J, Miuma S, Ouda IM, Waters CE, Saldivar JC, Druck T, Huebner K. Exome-wide single-base substitutions in tissues and derived cell lines of the constitutive Fhit knockout mouse. Cancer Science. 2016.
Karras JR*, Paisie CA*, Huebner K. Replicative stress and the FHIT gene: roles in tumor suppression, genome stability and prevention of carcinogenesis. Cancers (Basel). 2014.
Miuma S, Saldivar JC, Karras JR, Waters CE, Paisie CA, Wang Y, Jin V, Sun J, Druck T, Zhange J, Huebner K. Fhit deficiency-induced global genome instability promotes selective mutation and clonal expansion. PLoS ONE. 2013.
E-mail: jkarras@wistar.org
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