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Joshua Eggold, Ph.D.

Department of Pathology,
University of Pennsylvania


2015 B.A. Molecular and Cellular Biology- Vanderbilt University, Nashville, TN

2021 PhD Cancer Biology- Stanford University, Stanford, CA

2021-present Postdoctoral Investigator, Department of Pathology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

Research Mentor: Daniel J. Powell Jr., PhD
Research Topic: CAR T cell therapies for ovarian cancer

Teaching Interests: Introductory Biology, Cell Biology, Genetics, Biochemistry, Cancer Biology, Cancer Immunology

Eggold JT, Nambiar D, Natarajan S, Chow S, Krishnan V, Chan J, Liang R, Cheunkarndee T, Flowers B, Attardi L, Engleman E, Dorigo O, Le QT, Rankin EB. IL-33/ST2/IL-5Rα signaling axis identifies PMN-MDSCs in murine and human cancers. JI. In revision.

Eggold JT* and Chow S*, Wang J, Manjappa R, Melemenidis S, Natarajan S, Loo P, Kidd E, Engleman E, Dorigo O, Loo BW Jr, Rankin EB. Abdominal FLASH Irradiation Improves PD-1 Immune Checkpoint Inhibition in Preclinical Models of Ovarian Cancer. Mol Can Therapeutics. In press.

Levy K, Natarajan S, Wang J, Chow S, Eggold JT, Loo PE, Manjappa R, Melemenidis S, Lartey FM, Schüler E, Skinner L, Rafat M, Ko R, Kim A, H Al-Rawi D, von Eyben R, Dorigo O, Casey KM, Graves EE, Bush K, Yu AS, Koong AC, Maxim PG, Loo BW Jr, Rankin EB. (2020) Abdominal FLASH irradiation reduces radiation-induced gastrointestinal toxicity for the treatment of ovarian cancer in mice. Sci Rep, 10(1):21600

Natarajan S, Foreman KM, Soriano MI, Rossen NS, Shehade H, Fregoso DR, Eggold JT, Krishnan V, Dorigo O, Krieg AJ, Heilshorn SC, Sinha S, Fuh KC, Rankin EB. (2019) Collagen Remodeling in the Hypoxic Tumor-Mesothelial Niche Promotes Ovarian Cancer Metastasis. Cancer Res, 79(9):2271-2284

Eggold JT, Rankin EB. (2018) Erythropoiesis, EPO, Macrophages and Bone. Bone, pii: S8756-3282(18)30121-2.

Chen C, Shin JH, Eggold JT, Chung MK, Zhang LH, Lee J, and Sunwoo JB. (2016) ESM1 mediates NGFR-induced invasion and metastasis in murine oral squamous cell carcinoma. Oncotarget, 7(43):70738-70749.

Sowd GA, Mody D, Eggold J, Cortez D, Friedman K, and Fanning E. (2014) SV40 utilizes ATM kinase activity to prevent non-homologous end joining of broken viral DNA replication products. PLOS Pathogens, 10(12): e1004536.



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