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Nicole Bracci, Ph.D.

Department of Microbiology,
University of Pennsylvania


Education:

2017 B.S. Molecular and Cellular Biology – The Pennsylvania State University – University Park, PA

2017 B.S. Forensic Science – The Pennsylvania State University – University Park, PA

2022 Future Professoriate Graduate Certificate – Virginia Polytechnic Institute and State University- Blacksburg, VA

2022 Ph.D. Biomedical and Veterinary Sciences – Virginia Polytechnic Institute and State University – Blacksburg, VA

2022 – Present PennPORT Fellow, Department of Microbiology – University of Pennsylvania School of Medicine, Philadelphia, PA

Research Mentor: Susan Weiss, Ph.D.

Research Topic: Host immune responses for coronavirus and flavivirus infections

Teaching Interests: Molecular Biology, Virology, Cell Biology, General Microbiology,

       Publications:

Behnia, M., Baer, A., Skidmore, A., Lehman, C., Bracci, N., Kehn-Hall, K., & Bradfute, S. (2022). Inactivation of Venezuelan equine encephalitis virus genome using two methods. Viruses. 14(2), 272. https://doi.org/10.3390/v14020272

Bracci, N., de la Fuenta, C., Saleem, S., Pinkham, C., Narayanan, A., Garcia-Sastre, A., Balaraman, V., Richt, J., Wilson, W., & Kehn-Hall, K. (2021). Rift Valley fever virus Gn V5-epitope-tagged virus enables identification of UBR4 as a Gn interacting protein that facilitates Rift Valley fever virus production. Virology. 567(2022), 65. https://doi.org/10.1016/j.virol.2021.12.010

Tang, K. T., Chen, H. H., Chen, T. T., Bracci, N. R., & Lin, C. C. (2021). Dendritic Cells and Antiphospholipid Syndrome: An Updated Systematic Review. Life (Basel, Switzerland), 11(8), 801. https://doi.org/10.3390/life11080801

Chuo, W. H., Tung, Y. T., Wu, C. L., Bracci, N. R., Chang, Y. K., Huang, H. Y., & Lin, C. C. (2021). Alantolactone Suppresses Proliferation and the Inflammatory Response in Human HaCaT Keratinocytes and Ameliorates Imiquimod-Induced Skin Lesions in a Psoriasis-Like Mouse Model. Life (Basel, Switzerland), 11(7), 616. https://doi.org/10.3390/life11070616

Dahal, B., Lehman, C.W., Akhrymuk, I., Bracci, N.R., Panny, L., Barrera, M.D., Bhalla, N., Jacobs, J.L., Dinman, J.D., Kehn-Hall, K. (2021). PERK Is Critical for Alphavirus Nonstructural Protein Translation. Viruses. 13(5), 892. https://doi.org/10.3390/v13050892

Lin, S. C., Lehman, C., Stewart, A. K., Panny, L., Bracci, N., Wright, J., Paige, M., Strangman, W. K., & Kehn-Hall, K. (2021). Homoseongomycin, a compound isolated from marine actinomycete bacteria K3-1, is a potent inhibitor of encephalitic alphaviruses. Antiviral research, 191. https://doi.org/10.1016/j.antiviral.2021.105087

Lehman, C. W., Kehn-Hall, K., Aggarwal, M., Bracci, N., Pan, H. C., Panny, L., Lamb, R. A., & Lin, S. C. (2021). Resveratrol Inhibits Venezuelan Equine Encephalitis Virus Infection by Interfering with the AKT/GSK Pathway. Plants (Basel, Switzerland)10(2), 346. https://doi.org/10.3390/plants10020346

Bracci, N., Pan, H., Lehman, C., Kehn-Hall, K., Lin, S. (2020). Improved Plaque Assay for Human Coronaviruses 229E and OC43. PeerJ Journals8, e10639. https://doi.org/10.7717/peerj.10639

Lin, S., Lin, C., Li, S., Lin, W., Lehman, C., Bracci, N., & Tsai, S. (2020). Alleviation of Collagen-Induced Arthritis by Crotonoside through Modulation of Dendritic Cell Differentiation and Activation. Plants (Basel, Switzerland)9(11), E1535. https://doi.org/10.3390/plants9111535

Wu, C. S., Lin, S. C., Li, S., Chiang, Y. C., Bracci, N., Lehman, C. W., Tang, K. T., & Lin, C. C. (2020). Phloretin alleviates dinitrochlorobenzene-induced dermatitis in BALB/c mice. International journal of immunopathology and pharmacology34, 2058738420929442. https://doi.org/10.1177/2058738420929442

Carey, B. D., Akhrymuk, I., Dahal, B., Pinkham, C. L., Bracci, N., Finstuen-Magro, S., Lin, S. C., Lehman, C. W., Sokoloski, K. J., & Kehn-Hall, K. (2020). Protein Kinase C subtype δ interacts with Venezuelan equine encephalitis virus capsid protein and regulates viral RNA binding through modulation of capsid phosphorylation. PLoS pathogens16(3), e1008282. https://doi.org/10.1371/journal.ppat.1008282

Lin, S. C., Carey, B. D., Callahan, V., Lee, J. H., Bracci, N., Patnaik, A., Smith, A. K., Narayanan, A., Lepene, B., & Kehn-Hall, K. (2020). Use of Nanotrap particles for the capture and enrichment of Zika, chikungunya and dengue viruses in urine. PloS one15(1), e0227058. https://doi.org/10.1371/journal.pone.0227058

Gogovi, G. K., Almsned, F., Bracci, N., Kehn-Hall, K., Shehu, A., & Blaisten-Barojas, E. (2019). Modeling the Tertiary Structure of the Rift Valley Fever Virus L Protein. Molecules (Basel, Switzerland)24(9), 1768. https://doi.org/10.3390/molecules24091768

Lin, S., Chen, M., Liu, S., Callahan, V., Bracci, N., Lehman, C., Dahal, B., de la Fuente, C., Lin, C., Wang, T., & Kehn-Hall, K. (2019). Phloretin inhibits Zika virus infection by interfering with cellular glucose utilization. International journal of antimicrobial agents54(1), 80–84. https://doi.org/10.1016/j.ijantimicag.2019.03.017

Pinkham, C., Ahmed, A., Bracci, N., Narayanan, A., & Kehn-Hall, K. (2018). Host-based processes as therapeutic targets for Rift Valley fever virus. Antiviral research160. https://doi.org/10.1016/j.antiviral.2018.10.004

Almsned, F., Gogovi, G., Bracci, N., Kehn-Hall, K., Blaisten-Barojas, E., & Shehu, A. (2018). Modeling the Tertiary Structure of a Multi-domain Protein. Proceedings of the 2018 ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics - BCB 18. doi: 10.1145/3233547.3233702

Pinkham C, Dahal B, de la Fuente CL, Bracci N, Beitzel B, Lindquist M, Garrison A, Schmaljohn C, Palacios G, Narayanan A, Campbell CE, Kehn-Hall K. Alterations in the host transcriptome in vitro following Rift Valley fever virus infection. Sci Rep. 2017 Oct 30;7(1):14385. doi: 10.1038/s41598-017-14800-3. PMID: 29085037; PMCID: PMC5662566.

E-mail: nicole.bracci@pennmedicine.upenn.edu 

 

 

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