Patrick Cherubin, Ph.D.
Department of Microbiology,
University of Pennsylvania
2007 Career Diploma Photography – Penn Foster Career School, Scranton, PA
2010 A.A. General Studies – Valencia Community College, Orlando, FL
2012 B.S. Molecular Biology and Microbiology – University of Central Florida, Orlando, FL
2014 M.S. Biotechnology – University of Central Florida, Orlando, FL
2019 Ph.D. Biomedical Sciences – University of Central Florida, Orlando, FL
2019-Present PennPORT fellow, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia Research Institute – University of Pennsylvania School of Medicine, Philadelphia, PA
Research Mentor: Paul Bates, Ph.D.
Research Topic: Understand and elucidate key interactions between viruses and their host cells as a basis for therapeutic and prophylactic strategies. The Bates lab uses a combination of cell biology, molecular and genetic tools to investigate mechanisms by which viral surface proteins exploit cellular factors for host invasion, as well as for evasion of the host defenses. Current projects in the Bates lab focus on several pathogenic viruses, including coronaviruses (SARS-CoV-2), filoviruses (ebolavirus), and bunyaviruses (Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV)). We are interested in viral factors involved in host entry, notably ebolavirus glycoprotein and SARS-CoV-2 spike protein, as well as developing vaccine strategies against emerging viral pathogens, such as SFTSV, that are likely to cause imminent outbreaks.
Teaching Interests: General Biology, Host-Pathogen Interactions, Infectious Processes, Molecular Biology, Cell Biology
Cherubin P, Fidler D, Quiñones B, and Teter K. Bimodal Response to Shiga Toxin 2 Subtypes Results from Relatively Weak Binding to the Target Cell. Infect Immun. (2019). doi: 10.1128/IAI.00428-19.
Guyette J, Cherubin P, Serrano A, Taylor M, Abedin F, O'Donnell M, Burress H, Tatulian S, and Teter K. Quercetin-3-Rutinoside Blocks the Disassembly of Cholera Toxin by Protein Disulfide Isomerase. Toxins (Basel). (2019) 11(8). pii: E458. doi: 10.3390/toxins11080458.
Cherubin P, Guyette J, Taylor M, O'Donnell M, Herndon L, Burress H, Riad A, Tatulian S, and Teter K. Protein Disulfide Isomerase Does Not Act as an Unfoldase in the Disassembly of Cholera Toxin. Biosci Rep. (2018). 38(5). doi: 10.1042/BSR20181320.
Cherubin P, Quiñones B, and Teter K. Cellular Recovery from Exposure to Sub-Optimal Concentrations of AB Toxins that Inhibit Protein Synthesis. Sci Rep. (2018). 8(1): 2494. doi: 10.1038/s41598-018-20861-9.
Cherubin P, Quiñones B, Elkahoui S, Yokoyama W, and Teter K. A Cell-Based Fluorescent Assay to Detect the Activity of AB Toxins That Inhibit Protein Synthesis. Methods Mol Biol. (2017) 1600: 25-36.
Cherubin P, Garcia C, Curtis D, Britt C, Craft J, Buress H, Berndt C, Reddy S, Guyette J, Zheng T, Huo Q, Quiñones B, Briggs J, and Teter K. Inhibition of Cholera Toxin and Other AB Toxins by Polyphenolic Compounds. PLoS ONE. (2016) 11: e0166477.
Zheng T, Cherubin P, Cilenti L, Teter K, and Huo Q. A Simple and Fast Method to Study the Hydrodynamic Size Difference of Protein Disulfide Isomerase in Oxidized and Reduced Form Using Gold Nanoparticles and Dynamic Light Scattering. Analyst. (2015) 141: 934-938.
Reddy S, Taylor M, Zhao M, Cherubin P, Geden S, Ray S, Francis D, and Teter K. Grape Extracts Inhibit Multiple Events in the Cell Biology of Cholera Intoxication. PLoS ONE. (2013) 8: e73390.