Perelman School of Medicine at the University of Pennsylvania

Physics and Instrumentation Group

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Presentations

2019 IEEE Medical Imaging Conference

Effects of TOF resolution models on edge artifacts in PET reconstruction from limited angle data.

Gravel P, Matej S 
2019 IEEE Nuclear Science Symposium and Medical Imaging Conference
Manchester, England. MIC-09-06.

Analytic determination of rectangular-pinhole sensitivity with penetration.

Metzler SD, Moore SC
2019 IEEE Nuclear Science Symposium and Medical Imaging Conference,
Manchester, England.  

Dynamic imaging on the long axial field of view PennPET Explorer.

Viswanath V, Pantel AR, Daube-Witherspoon ME, Muzi M, Mankoff DA, Karp JS 
2019 IEEE Nuclear Science Symposium and Medical Imaging Conference
Manchester, England. MIC-08-05.

Quantification of Defect Contrast in MicroSPECT Imaging of a Myocardial Phantom

Johnson LC, Guerraty MA, Moore SC, Metzler SD
2019 IEEE Nuclear Science Symposium and Medical Imaging Conference
Manchester, England. MIC-08.

Dual-Gated Imaging with C-SPECT

Stentz D, Johnson LC, Sankar P, Arseneau R, Chang W, Karp JS,  Metzler SD
2019 IEEE Nuclear Science Symposium and Medical Imaging Conference
Manchester, England. MIC-08.

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2019 Society of Nuclear Medicine and Molecular Imaging Annual Meeting

Quantitative renal PET imaging with Rubidium-82 can discriminate individuals with different degres of renal impairment.

Bravo PE, Fuchs B, Tahari AK, Thorpe M, Howard J, Guerraty M, Metzler SD, Pryma D, Dubroff J, Rahmim A.
J Nucl Med, vol. 60, suppl. 1, #164. 

First-in-human biodistribution and dosimetry of [11C]trimethoprim.

Doot R, Young A, Schubert E, Cai J, Lee H, Mach R, Mankoff D,Sellmyer M.
J Nucl Med, vol. 60, suppl. 1, #1642.

Performance evaluation of resolution/sensitivity variable slats-stack collimator of C-SPECT cardiac scanner.

Sankar P, Stentz D, Johnson L, Chang W, Karp JS, Metzler SD
J Nucl Med
, vol. 60, suppl. 1, #191

Impact of improved PET spatial and timing resolution on lesion detectability in oncology.

Surti S, Reddin J, Scheuermann J, Daube-Witherspoon M, Conti M, Casey M, Karp JS 
J Nucl Med, vol. 60, suppl. 1, #459.

Lesion detectability in long axial field of view TOF PET scanners.

Viswanath V, Daube-Witherspoon M, Karp J, Surti S.
J Nucl Med, vol. 60, suppl. 1, #107.

Deep learning-based denoising for PennPET Explorer data.

Wu J, Daube-Witherspoon M, Liu H, Lu WZ, Onofrey J, Karp J, Liu C
J Nucl Med, vol. 60, suppl. 1, #574.

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2019 Meeting of the American Association of Physicists in Medicine

Adaptive imaging

Szczykutowicz,T Metzler S, Stafford R, Namias M.
Med Phys vol. 46: E478, 2019.

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2019 Fully 3D Meeting

Reconstruction performance for long axial field-of-view PET scanners with large axial gaps.

Daube-Witherspoon ME, Viswanath V, Surti S, Karp JS
The 15th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine
Philadelphia, PA, 2019. P-1.29.

Joint reconstruction of activity and attenuation with autonomous scaling for time-of-flight PET.

Li Y, Matej S, Karp JS
The 15th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine
Philadelphia, PA, 2019. EM-3.2.

Simultaneous micro-PET imaging of F-18 and I-124 with correction for triple-random coincidences.

Moore SC, Krishnamoorthy S, Blankemeyer E, Carlin SD, Karp JS, Metzler SD 
The 15th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine
Philadelphia, PA, 2019. EM-1.1

Non-TOF Fourier-based analytic reconstruction for TOF histo-projections for high resolution TOF scanners.

Panin VY, Matej S
The 15th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine
Philadelphia, PA, 2019. EM-1.3.

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2018 IEEE Medical Imaging Conference

Reconstruction approaches for long axial field-of-view PET scanners.

Daube-Witherspoon ME, Viswanath V, Matej S, Surti S, Karp JS.
2018 IEEE Nuclear Science Symposium and Medical Imaging Conference 
Sydney, Australia. M-14-261

Task-based assessment of performance of a long axial field-of-view PET scanner.

Daube-Witherspoon ME, Surti S, Viswanath V, Gravel P, Matej S, Karp JS.
2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
Sydney, Australia. MIC-WS2 II

Design for an extended AFOV PET/CT scanner.

Geagan MJ, McDermott T, Muehllehner G, Parma MJ, Perkins AE, Schmall J, Werner M, Karp JS.
2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
Sydney, Australia. MIC-WS2 II

Spatially-varyiant image-based modeling of PSF deformations with application to limited angle dual-panel breast PET data.

Gravel P, Surti S, Krishnamoorthy S, Karp JS, Matej S.
2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
Sydney, Australia. M-14-258

First human studies with the long axial field-of-view PennPET Explorer scanner.

Karp JS, Viswanath V, Parma MJ, Werner ME, Geagan MG, Schmall JP, Reddin JS, Perkins AE, Muehllehner G, Daube-Witherspoon ME.
2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
Sydney, Australia. MIC-WS2 III.

Attenuation correction in a combined, single-gantry breast PET-Tomosynthesis scanner.

Krishnamoorthy S, Vent T, Barufaldi B, Maidment ADA, Karp JS, Surti S.
2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
Sydney, Australia. M-03-346.

A modular waveform-sampling data acquisition system for time-of-flight PET. 

Krishnamoorthy S, Morales E, Ashmanskas WJ, Mayer G, Hu R-W, LeGeyt BC, Karp JS, Surti S. 
2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
Sydney, Australia. M-07-152.

Maximum likelihood joint reconstruction of activity and attenuation factors from time-of-flight PET histoimages.

Li Y, Viswanath V, Karp JS, Matej S.
2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
Sydney, Australia. M-07-257.

First imaging data with C-SPECT: A dedicated human cardiac SPECT imager.

Metzler SD, Sankar P, Stentz DJ, Karp JS, Johnson LC, Chang W.
2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
Sydney, Australia. M-11-02.

Performance evaluation of the SiPM based Siemens Biograph Vision PET/CT system.

Reddin JS, Scheuermann JS, Bharkhada D, Smith AM, Casey ME, Conti M, Karp JS.
2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
Sydney, Australia. M-11-03.

Improved lesion detectability and short imaging times with long axial field-of-view TOF PET.

Surti S, Viswanath V, Daube-Witherspoon ME, Karp JS.
2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
Sydney, Australia. M-14-381.

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2018 Functional NeuroReceptor Brain Mapping Conference

Greater dopamine D3 receptor availability in males than females as determined by [18F] Flurotriopride, a D3 receptor selective radiotracer.

Dubroff J, Doot R, Ward C, Labban K, Cai J, Lee H, Schubert E, O’Sullivan F, Mach R.
12th International Symposium on Functional NeuroReceptor Mapping of the Living Brain
London, England, #P40.

Assessment of a statistical arterial input function extraction technique from [18F]fluortriopride PET images.

Doot R, Dubroff J, Ward C, Labban K, Cai J, Li S, Lee H, Schubert E, mach R, O’Sullivan F.
12th International Symposium on Functional NeuroReceptor Mapping of the Living Brain,
London, England, #P8.

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2018 Total Body PET Conference

The PennPET Explorer with scalable axial field-of-view: Design and initial measurements.

Karp JS, Viswanath V, Schmall JP, Werner ME, Parma MJ, Matej S, Daube-Witherspoon ME, McDermott T, Geagan MJ, Muehllehner G, Tung C-H, Perkins AE.
2018 Total Body PET Conference, Ghent, Belgium
EJNMMI Phys. 2018 Jun; 5(Suppl 1): 19 (Abstract S2)

Feasibility of simultaneous dual-radionuclide time-of-flight PET imaging with PennPET Explorer.

Moore SC, Viswanath V, Metzler SD, Herraiz JL, Karp JS.
2018 Total Body PET Conference, Ghent, Belgium
EJNMMI Phys. 2018 Jun; 5(Suppl 1): 19 (Abstract A24)

Quantifying improved lesion detectability of the 70-cm PennPET Explorer using GATE simulations.

Viswanath V, Surti S, Daube-Witherspoon ME, Schmall JP, Karp JS.
2018 Total Body PET Conference, Ghent, Belgium
EJNMMI Phys. 2018 Jun; 5(Suppl 1): 19 (Abstract A20)

Dynamic imaging on the 70-cm PennPET Explorer using GATE simulations.

Viswanath V, Pantel AR, Daube-Witherspoon ME, Mankoff DA, Karp JS.
2018 Total Body PET Conference, Ghent, Belgium
EJNMMI Phys. 2018 Jun; 5(Suppl 1): 19 (Abstract A21)

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2018 Society of Nuclear Medicine and Molecular Imaging Annual Meeting

Investigation of acquisition strategies for ]Ga-68]P15-041 bone imaging in prostate cancer.

Daube-Witherspoon M, Alexoff D, Kung H, Reddin J, Pryma D, Karp J.
J Nucl Med, vol. 59, suppl. 1, #1094.

First-in-human experience with [68Ga]P16-093, a novel Ga-68 labeled prostate specific membrane antigen (PSMA) inhibitor.

Doot R, Alexoff D, Pryma D, Labban K, Schubert E, Fillare M, Ploessl K, Choi S, Zha Z, Mankoff D, Kung H.
J Nucl Med, vol. 59, suppl. 1, #52. 

Imaging performance of the PennPET Explorer scanner.

Karp J, Schmall J, Geagan M, Werner M, Parma M, Matej S, Daube-Witherspoon M, Viswanath V, McDermott T, Muehllehner G, Perkins A, Tung CH.
J Nucl Med, vol. 59, suppl. 1, #222.

Ultrasound-based sensors for motion correction of PET data.

Cheng CC, Belsley G, Moore SC, Preiswerk F, Wu P-H, Kijewski MF, Campbell L, DiCarli MF, Madore B.
J Nucl Med, vol. 59, suppl. 1, #8.

Axial dependent SUV variance with and without knitting: Implications for automated reconstruction optimization.

Li Y, Daube-Witherspoon M, Matej S, Metzler SD.
J Nucl Med, vol. 59, suppl. 1, #1777. 

Design and engineering of clinical C-SPECT patient and task specific slits for optimizing sensitivity.

Sankar P, Stentz D, Johnson L, Moore S, Chang W, Karp JS, Metzler S.
J Nucl Med, vol. 59, suppl. 1, #1761.

Characterizing the TOF performance of the PennPET Explorer scanner.

Schmall J, Geagan M, Werner M, Parma M, Viswanath V, McDermott T, Perkins A, Karp J.
J Nucl Med, vol. 59, suppl. 1, #96.

Investigating low-dose image quality in pediatric TOF-PET/MRI.

Schmall J, Nevo E, Edwards K, Magee R, Servaes S, Karp J, States L.
J Nucl Med, vol. 59, suppl. 1, #304.

Spatial and energy resolutions measurements for C-SPECT.

Stentz D, Sankar P, Arseneau R, Chang W, Karp J, Metzler S.
J Nucl Med, vol. 59, suppl. 1, #218.

Design study for MRC-SPECT-C: A MR-compatible cardiac SPECT system for simultaneous SPECT/MR cardiac imaging.

Zannoni EM, Zhang J, Ma C, Ouyang J, Metzler SD, Meng L-J.
J Nucl Med, vol. 59, suppl. 1, #357. 

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2017 American Heart Association Annual Meeting

Multimodality blood flow imaging in mice.

Gerraty MA, Johnson LC, Blankemeyer E, Wang T, Mankoff DA, Metzler SD, Rader DJ.
2017 American Heart Association Annual Meeting, Anaheim, CA.

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2017 American College of Neuropsychopharmacology Annual Meeting

Healthy human male dopamine D3 receptor uptake of [18F]fluortriopride (FTP) before and after lorazepam challenge.

Doot R, Dubroff J, Labban K, Cai J, Lee H, Schubert E, Hsieh CJ, Hou C, Sheffer R, Zu K, Li S, Schmitz A, O’Sullivan F, Mach R.
ACNP 56th Annual Meeting, Palm Springs, #M239.

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2017 IEEE Medical Imaging Conference

Cardiac phantom for improved small-animal dynamic SPECT myocardial blood flow quantification.

Johnson LC, Guerraty M, Matej D, Metzler SD.
2017 IEEE Nuclear Science Symposium and Medical Imaging Conference
Atlanta, Georgia. M-18-6.

The PennPET Explorer scanner for total body applications.

Karp JS, Geagan MJ, Muehllehner G, Werner ME, McDermott T, Schmall JP, Viswanath V, Perkins AE, Tung C-H.
2017 IEEE Nuclear Science Symposium and Medical Imaging Conference
Atlanta, Georgia.M-09-1.

Imaging performance of the MOLECUBES β-CUBE – a dedicated small animal PET scanner using monolithic LYSO scintillator.

Krishnamoorthy S, Blankemeyer E, Mollet P, Surti S. Holen RV, Karp JS.
2017 IEEE Nuclear Science Symposium and Medical Imaging Conference
Atlanta, Georgia. M-15-022.

Developing an expert system to improve lesion quantification for personalized PET imaging.

Li Y, Daube-Witherspoon ME, Matej S, Metzler SD.
2017 IEEE Nuclear Science Symposium and Medical Imaging Conference
Atlanta, Georgia. M-15-065.

Axial Fourier rebinning for time-of-flight PET.

Li Y, Matej S, Metzler SD.
2017 IEEE Nuclear Science Symposium and Medical Imaging Conference
Atlanta, Georgia. M-20-5.

Using higher energy radioisotopes for crystal identification in a SPECT system.

Stentz D, Sankar P, Chang W, Karp JS, Metzler SD.
2017 IEEE Nuclear Science Symposium and Medical Imaging Conference 
Atlanta, Georgia. M-08-031.

GATE simulations to study extended axial FOVs for the PennPET Explorer scanner.

Viswanath V, Daube-Witherspoon ME, Werner ME, Surti S, Trindade A, Rodrigues P, Perkins AE, Karp JS.
2017 IEEE Nuclear Science Symposium and Medical Imaging Conference 
Atlanta, Georgia. M-19-4.

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2017 Society of Nuclear Medicine and Molecular Imaging Annual Meeting

Employing intrinsic physiology to reduce gallbladder radiation dose from PET radiotracers.

Doot R, Dubroff J, Scheuermann J, Hsieh C, Cai J, Lee S, Schubert E, Hou C, Sheffer R, Xu K, Li S, Mach R.
J Nucl Med, vol. 58, suppl. 1, #201.

Collimator design for a dedicated human cardiac SPECT system with high resolution detectors.

Metzler S, Meng L-J.
J Nucl Med, vol. 58, suppl. 1, #29.

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2017 Fully 3D Meeting

Estimating the Precision of Lesion Uptake Measurements. 

Daube-Witherspoon ME, Karp JS, Matej S, Li Y, Metzler SD
The 14th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine
Xi'an Shaanxi, China 2017. P 209-212.

Lesion Quantification Using the Local Impulse Response from Embedded Point Source. 

Li Y, Daube-Witherspoon ME, Matej S, Metzler SD
The 14th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine
Xi'an Shaanxi, China 2017. P 272-275.

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2016 IEEE Medical Imaging Conference

Discrete iterative algorithms for scatter-to-attenuation reconstruction in PET.

Berker Y, Schulz V, Karp JS.
2016 IEEE Nuclear Science Symposium and Medical Imaging Conference
Strasbourg, France. M10A-5.

Quantitative accuracy of time-of-flight PET at high count rates.

Daube-Witherspoon ME, Viswanath V, Surti S, Matej S, Karp JS.
2016 IEEE Nuclear Science Symposium and Medical Imaging Conference
Strasbourg, France. M16B-15.

Design of a dual-resolution, rectangular-pinhole collimator with improved projection tiling for small-animal imaging

Johnson LC, Liu Z, Park M-A, Moore SC, Metzler SD.
2016 IEEE Nuclear Science Symposium and Medical Imaging Conference
Strasbourg, France. M12-2.

Parameter optimization for blob-based image reconstruction with generalized Kaiser-Bessel radial functions.

Li Y, Matej S, Metzler SD.
2016 IEEE Nuclear Science Symposium and Medical Imaging Conference
Strasbourg, France. M13A-11.

Implications of bias-correction on mean-squared error for optimizing reconstruction.

Metzler SD, Daube-Witherspoon ME, Karp JS, Matej S.
2016 IEEE Nuclear Science Symposium and Medical Imaging Conference
Strasbourg, France. M16B-22.

Whole-body preclinical SPECT imaging: Scanning without multiplexing vs. stationary imaging with multiplexing.

Moore SC, Kijewski MF, Johnson LC, Metzler SD.
IEEE Nuclear Science Symposium and Medical Imaging Conference
Strasbourg, France. M13A-11. 

Evaluation of the imaging performance of continuous detectors etched with laser induced optical barriers.

Panetta J, Surti S, Bingh B, Karp J.
2016 IEEE Nuclear Science Symposium and Medical Imaging Conference
Strasbourg, France. M08-3.

Investigating CeBr3 for ultra-fast TOF-PET detector designs.

Schmall JP, Surti S, Dokhale P, Ferri A, Gola A, Piemonte C, Shah K, Karp JS.
2016 IEEE Nuclear Science Symposium and Medical Imaging Conference
Strasbourg, France. M13B-14.

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2016 Functional NeuroReceptor Brain Mapping Conference

Biodistribution and dosimetry of [18F]fluortriopride, a dopamine D3 receptor selective PET radiotracer, in healthy humans.

Doot R, Dubroff J, Scheuermann J, Cai J, Hsieh C, Lee H, Schubert E, Hou C, Sheffer R, Xu K, Li S, Mach R.
11th International Symposium on Functional NeuroReceptor Mapping of the Living Brain,
Boston, MA, #P109.

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