Mortimer Civan

Emeritus Professor

215-898-8773
civan@pennmedicine.upenn.edu

A303 Richards Building

3700 Hamilton Walk

Philadelphia, PA 19104

Research Description

My laboratory is primarily concerned with: (1) the mechanisms of movement of solutes and water across epithelial membranes, (2) the regulation of that movement, and (3) the clinical implications of altering the underlying mechanisms and regulation. Our current focus is on the mechanisms and regulation of aqueous humor inflow into, and exit from, the eye, and their implications for the treatment of glaucoma. Two broad lines of in vitro work are in progress using the techniques of patch clamping, molecular biology, fluorescence microscopy and electronic cell sorting. First, we are seeking to identify the molecular basis for chloride-channel activity, which likely limits the rate of ciliary epithelial secretion. Second, we are also testing our current hypothesis concerning the autocrine and paracrine basis for purinergic regulation of aqueous humor secretion and efflux. We are testing our hypotheses, developed on the basis of our in vitro work, using measurements of intraocular pressure in the mouse.

Degrees & Education

AB, Columbia College, 1955

MD, Columbia University, 1959

Honors & Awards

Fellow, American Association for the Advancement of Science

Established Investigator, American Heart Association

Member, American Society for Clinical Investigation

Overseas Fellow, Churchill College, University of Cambridge

Dean's Award for Excellence in Teaching Basic Science, University of Pennsylvania Perelman School of Medicine

Harold Chaffer Memorial Lecturer, Faculty of Medicine, University of Otago, Dunedin, New Zealand

Fellow, Assoc. for Research in Vision Ophthalmology

Other Perelman School of Medicine Affiliations

Cell and Molecular Biology Graduate Program

Program in Cellular Physiology

Bioengineering Graduate Group

Institute for Medicine and Engineering

Department of Medicine

Professional Affiliations

Society of General Physiologists

American Society for Clinical Investigation

Association for Research in Vision & Ophthalmology

American Physiological Society

Biophysical Society

International Society for Eye Research

Salt and Water Club

Recent Publications
January 1, 2008
Aqueous Humor and the Dynamics of Its Flow: Mechanisms and Routes of Aqueous Humor Drainage, In: Albert and Jakobiec's Principles and Practice of Ophthalmology
Mortimer Civan, M.D.
Freddo, T.F., Civan, M., and Gong, H - pp 1-46, 4th Edition.
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