Erika Holzbaur, PhD

William Maul Measey Professor

Lab Web Site

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638A Clinical Research Building

415 Curie Boulevard

Philadelphia, PA 19104


Lab: 215-573-3481

Fax: 215-573-2273

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Erika Holzbaur, PhD

William Maul Measey Professor of Physiology

Other Perelman School of Medicine Affiliations

Degrees & Education

  • PhD, Pennsylvania State University, 1987

  • BS, College of William and Mary, 1982

Awards & Honors

  • William Maul Measey Endowed Professor

  • Jane M. Glick Teaching Award

  • Javits Neuroscience Investigator Award

  • Keith R. Porter Fellowship Award

  • Established Investigator of the American Heart Association

  • Pfizer Award for Research Excellence

  • NIH Postdoctoral Fellowship, NINDS

  • Frank Malette Award for Graduate Distinction in Biochemistry

  • Phi Beta Kappa

Professional Affiliations

  • American Society for Cell Biology

  • American Association for the Advancement of Science

Research Description

Our laboratory is focused on the microtubule-based motor cytoplasmic dynein and its activator dynactin. Dynein and dynactin are required for vesicular trafficking, mitotic spindle assembly, and development of polarity. We are interested in mechanisms of force production and motor function, mechanisms of cargo coupling and regulation, effects of dynein and dynactin on dynamics of the cytoskeleton, and the analysis of neurodegenerative diseases resulting from impairments in dynein/dynactin function. Disruptions in dynein/dynactin function cause motor neuron degeneration and muscle atrophy, leading to motor neuron diseases similar to ALS. Approaches in the lab include in vitro motility assays, cellular transfection assays, live cell microscopy, and development and characterization of transgenic mouse models for motor neuron disease.

Click here for a full list of publications.
(searches the National Library of Medicine's PubMed database.)

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