Paul Jamney, PhD

Professor

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1010 Vagelos Laboratories

3340 Smith Walk

Philadelphia, PA 19104

215-573-7380

Fax: 215-573-6815

janmey@pennmedicine.upenn.edu

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Paul Janmey, PhD


Professor of Physiology

Other Perelman School of Medicine Affiliations


Degrees & Education

  • PhD, University of Wisconsin, 1982

  • AB, Oberlin College, 1976


Honors

  • 1999 Rotschild-Yvette Mayent Award, Institut Curie


Professional Affiliations

  • American Society for Cell Biology

  • Biophysical Society


Research Description

Our lab studies several aspects of cell mechanics. In one project, we produce soft materials, usually hydrogels, to which cell adhesion proteins are linked to study how the stiffness of surfaces alters cell structure, function, and growth. Endothelial cells, fibroblasts, neurons and astrocytes each show unique dependence on substrate stiffness, and we seek to understand how they sense and respond to this mechanical cue. In related work we measure the structure and viscoelasticity of cytoskeletal polymer networks using a variety of imaging, scattering, and rheologic methods. Further studies examine how changes in cell membrane structure mediated by inositol phospholipids lead to production of signals that remodel the cytoskeleton.


Click here for a full list of publications.
(searches the National Library of Medicine's PubMed database.)


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