H. Lee Sweeney, PhD

Emeritus Professor

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UF Dept of Pharmacology & Therapeutics

1200 Newell Drive; ARB R5-234

PO Box 100267

Gainesville, FL 32610



Assistant: Christina Stout

Phone: 352-294-5357


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H. Lee Sweeney, PhD

William Maul Measey Professor

Other Perelman School of Medicine Affiliations

Degrees & Education

  • SB, Massachusetts Institute of Technology, 1975

  • AM, Harvard University, 1980

  • PhD, Harvard University, 1984


  • William Maul Measey Professor in Physiology

  • Fellow of the American Heart Association

Professional Affiliations

  • Biophysical Society

  • American Heart Association (Basic Research Council)

  • American Society for Biochemistry & Molecular Biology

  • Society of General Physiologists

  • American Society for Cell Biology

Research Interests

  • Molecular motors; muscle injury and disease; gene transfer into striated muscle; myofibrillogenesis

Research Description

Dr. Sweeney's research interests include the molecular motors of the myosin superfamily. Notable among his accomplishments on molecular motors was the first visualization of structural rearrangement of the myosin lever arm, a detailed analysis of how processive myosins are engineered, a demonstration of the structural changes induced by actin-binding and nucleotide release, and the discovery and molecular dissection of the only known reverse-direction myosin. He is currently working to understand the fundamental motor mechanism resulting from myosin’s interaction with actin. He also is seeking to understand design specializations of a number of unconventional myosins, with a primary focus on myosin VI.

Much of Dr. Sweeney’s research program is translational in focus, and has produced highly cited research on inherited forms cardiovascular disease and on the skeletal and cardiac aspects of muscular dystrophy. Dr. Sweeney has been Director of a Paul Wellstone Muscular Dystrophy Cooperative Center since 2005. Dr. Sweeney is actively developing therapeutics for rare diseases with a focus on the muscular dystrophies. While he is primarily working with small molecules and biologicals, he also is evaluating gene therapy approaches.

Click here for a full list of publications.
(searches the National Library of Medicine's PubMed database.)

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