Paul Titchenell, PhD

Assistant Professor

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Lab Website

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Smilow Center for Translational Research

3400 Civic Center Blvd

Room: 12-104

Philadelphia, PA 19104

Office: 215-573-1872

Lab: 215-573-1875

ptitc@pennmedicine.upenn.edu

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Paul Titchenell, PhD


Assistant Professor of Physiology

Other Perelman School of Medicine Affiliations


Degrees & Education

  • BS, Biochemistry and Molecular Biology, Dickinson College, 2008

  • PhD, Physiology, Pennsylvania State University, 2013


Awards & Honors

  • 2016 Career Development Award NIDDK

  • 2015 Rising Star in Metabolism and Diabetes University of Utah, Salt Lake City, UT

  • 2015 Keystone Symposia Scholarship (NIDDK), J6 Diabetes and Metabolic Dysfunction, Santa Fe, NM

  • 2013 NRSA Fellowship NIDDK


Professional Affiliations

  • American Diabetes Association


Research Interests

Insulin signaling, Insulin resistance, Metabolism

Research Description

My research interests are focused on the regulation of metabolism by hormones and nutrients, with a particular emphasis on the master regulators of organismal metabolism, insulin and glucose. Alterations in insulin and glucose signaling underlie metabolic disease and lead to the development of deadly vascular and neuronal complications. Through the use of various techniques encompassing molecular biology, biochemistry, metabolomics, genome-wide transcriptional techniques and whole-animal physiology, the long-term goals of my research program are to decipher the underlying mechanisms driving metabolic deregulation during disease and identify new therapies that improve metabolic control.


Lab Members

    Matthew Gavin, Research Specialist

    Kahealani Uehara, BMB Rotation Graduate Student

    Rebecca Gelfer, Undergraduate Researcher

    Brennan Rose, Undergraduate Researcher


Selected Publications

  • Titchenell Paul M, Lazar Mitchell A, Birnbaum Morris J: Unraveling the Regulation of Hepatic Metabolism by Insulin. Trends in endocrinology and metabolism: TEM Apr 2017.

  • Papazyan Romeo, Sun Zheng, Kim Yong Hoon, Titchenell Paul M, Hill David A, Lu Wenyun, Damle Manashree, Wan Min, Zhang Yuxiang, Briggs Erika R, Rabinowitz Joshua D, Lazar Mitchell A: Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. Cell metabolism 24(6): 863-874, Dec 2016.

  • Jang Hagoon, Lee Gha Young, Selby Christopher P, Lee Gung, Jeon Yong Geun, Lee Jae Ho, Cheng Kenneth King Yip, Titchenell Paul, Birnbaum Morris J, Xu Aimin, Sancar Aziz, Kim Jae Bum: SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding. Nature communications 7: 12180, Jul 2016.

  • Titchenell Paul M, Quinn William J, Lu Mingjian, Chu Qingwei, Lu Wenyun, Li Changhong, Chen Helen, Monks Bobby R, Chen Julia, Rabinowitz Joshua D, Birnbaum Morris J: Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production. Cell metabolism 23(6): 1154-66, Jun 2016.

  • Titchenell Paul M, Chu Qingwei, Monks Bobby R, Birnbaum Morris J: Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo. Nature communications 6: 7078, May 2015.

  • Perry Rachel J, Camporez João-Paulo G, Kursawe Romy, Titchenell Paul M, Zhang Dongyan, Perry Curtis J, Jurczak Michael J, Abudukadier Abulizi, Han Myoung Sook, Zhang Xian-Man, Ruan Hai-Bin, Yang Xiaoyong, Caprio Sonia, Kaech Susan M, Sul Hei Sook, Birnbaum Morris J, Davis Roger J, Cline Gary W, Petersen Kitt Falk, Shulman Gerald I: Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell 160(4): 745-58, Feb 2015.


Click here for a full list of publications.
(searches the National Library of Medicine's PubMed database.)


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