PMI members organize courses and provide research training in muscle, cell motility, and the cytoskeleton through graduate programs in the School of Medicine, the School of Arts and Sciences, and the School of Engineering and Applied Science.
See below to learn more about our courses and research.
Cell Migration and Intracellular Transport
Cell migration and intracellular transport are complex cellular processes that require a dynamic cytoskeleton (actin and microtubules) and molecular motors (myosin, kinesin, and dynein).
Cell migration includes whole-cell locomotion and the regulation of the cell shape and extracellular attachment. Cell migration is crucial for several normal and pathological processes, including: cell and tissue development, wound healing, immune response, and metastases of tumors.
Intracellular transport is the movement and targeting of vesicles and proteins to specific cellular regions. Sometimes this transport occurs over long distances, like down the nerve axon, and sometimes this transport is simply the movement of a vesicle through the cell cortex. Transport also includes the proper delivery and localization of organelles (e.g., mitochondria).
Members of the Pennsylvania Muscle Institute are using and developing state-of-the-art techniques to understand the molecular events required for the regulation of cell migration and intracellular transport.
Vivianne T. Nachmias, Ph.D.
Daniel Safer, Ph.D.