PMI members organize courses and provide research training in muscle, cell motility, and the cytoskeleton through graduate programs in the School of Medicine, the School of Arts and Sciences, and the School of Engineering and Applied Science.
See below to learn more about our courses and research.
Structure/Function Studies of Molecular Motors
Molecular motors (dynein, kinesin, and myosin) are Nature's engineering masterpieces. These remarkable proteins use chemical energy (ATP) to generate mechanical force and motion, and in doing so, play key roles in nearly every physiological process. Muscle contraction is one of the most dramatic examples of motor function.
PMI members are determining - at the atomic level - how molecular motors use ATP to generate motility. Members use a combination of techniques to determine the ATP-induced structural changes in the motor that lead to force generation. These techniques include single-molecule spectroscopy, single-molecule force measurements, heterologous expression of mutant molecular motors, and transient biochemical kinetic measurements.