For more news highlights about basic science research at PennMedicine, see the PennMedicine Benchmarks e-newsletter.
- Strong Connection between Violence and Mental Illness in Guatemala During Civil War Lessens in Postwar Period, Penn Study Finds
26 Feb 2015
Violence during the civil war in Guatemala from 1960 to 1996 resulted in the development of significant mental health problems and conditions for the county’s people, according to a new multi-institution study from researchers under the Guatemala-Penn Partnership.
- Penn Medicine Physician Finds No Preventive Benefits for Widely Used Kidney Cancer Drugs
23 Feb 2015
Two widely used targeted therapy drugs— approved by the FDA for use in metastatic kidney cancer —are no more effective than a placebo in preventing return of the disease to increase life spans of patients suffering from advanced kidney cancer after surgery, according to new results to be presented by a researcher at the University of Pennsylvania’s Abramson Cancer Center (ACC) during the 2015 Genitourinary Cancers Symposium.
- Palbociclib Shows Promise in Patients with Hormone-Resistant Breast Cancer, Penn Study Finds
20 Feb 2015
Palbociclib, an investigational oral medication that works by blocking molecules responsible for cancer cell growth, is well tolerated and extends progression-free survival (PFS) in newly diagnosed, advanced breast cancer patients, including those whose disease has stopped responding to traditional endocrine treatments, Penn Medicine researchers found.
- Eczema Medication Unlikely to Increase Risk of Cancer in Children, Penn Team Finds
19 Feb 2015
The topical eczema medicine pimecrolimus appears unlikely to be associated with an increased risk of cancer in children, based on a group of children who were followed for 10 years, according to study published online this week in JAMA Dermatology.
- Penn Medicine Study Describes Development of Personalized Cellular Therapy for Brain Cancer
18 Feb 2015
Immune cells engineered to seek out and attack a type of deadly brain cancer were found to be both safe and effective at controlling tumor growth in mice that were treated with these modified cells, according to a study published in Science Translational Medicine by a team from the Perelman School of Medicine at the University of Pennsylvania and the Novartis Institutes for BioMedical Research. The results paved the way for a newly opened clinical trial for glioblastoma patients at Penn.
- Organizational Culture and Climate Predicts Use of Evidence-based Practices in the Treatment of Youth with Psychiatric Disorders
16 Feb 2015
Many mental health therapists use treatments that have little evidence to support them. A new multi-institution study led by Penn Medicine has found that an organization’s culture and climate are better predictors of the use of evidence-based practices than an individual therapist’s characteristics in the treatment of children and adolescents with psychiatric disorders.
- Penn Orphan Disease Center Announces First Grant Recipients from Million Dollar Bike Ride
13 Feb 2015
The Orphan Disease Center at the Perelman School of Medicine at the University of Pennsylvania, has awarded its inaugural grants funded by proceeds from the 2014 Million Dollar Bike Ride.
- Cancer Patients Rarely Demand Unnecessary Tests and Treatments, According to Penn Medicine Study
12 Feb 2015
Physicians often blame patient demands for contributing to high medical costs, however, a new study involving more than 5,000 patient-clinician visits indicates that cancer patients rarely push for unnecessary tests and treatments from their health care providers.
- Penn Medicine Researchers Show Brain Activity Can Predict Increased Fat Intake Following Sleep Deprivation
11 Feb 2015
Experts have warned for years that insufficient sleep can lead to weight gain. A new Penn Medicine study found that not only do we consume more food following a night of total sleep deprivation, but we also we consume more fat and less carbohydrates and a region of the brain known as the salience network is what may lead us to eat more fat.
- Common Biomarkers of Sleep Debt Found in Humans, Rats, Penn Study Finds
11 Feb 2015
In a study published this week in the Proceedings of the National Academy of Sciences, Penn Medicine researchers found common molecules signifying perturbed metabolism in response to sleep restriction in a comprehensive metabolic profiling of blood from both rats and humans.
- Penn Medicine Completes 1,000th Non-Surgical Aortic Valve Replacement Procedure
10 Feb 2015
Penn Medicine physicians have completed their 1,000th transcatheter aortic valve replacement (TAVR) procedure, marking an important milestone in the health system’s treatment of aortic stenosis, a narrowing of the heart’s aortic valve.
- Smartphone Apps Just as Accurate as Wearable Devices for Tracking Physical Activity, According to Penn Researchers
10 Feb 2015
Although wearable devices have received significant attention for their ability to track an individual’s physical activity, most smartphone applications are just as accurate, according to a new research letter in JAMA.
- Immune Biomarkers Help Predict Early Death, Complications in HIV Patients with TB, Penn Study Finds
9 Feb 2015
In a new study published online this week in The Lancet Infectious Diseases, researchers under the Botswana-UPenn Partnership at the University of Pennsylvania have identified immune biomarkers in patients before they begin antiretroviral therapy that could help distinguish those who will fare well and those who will worsen.
- Sharp, Sustained Increases in Suicides Closely Shadowed Austerity Events in Greece, Penn Study Finds
3 Feb 2015
Sharp and significant increases in suicides followed select financial crisis events and austerity announcements in Greece, from the start of the country’s 2008 recession to steep spending cuts in 2012, Penn Medicine researchers report in a new study published online this week in the British Medical Journal Open.
- Penn Medicine Encourages Women to Love Themselves with a Free Mammogram this Valentine's Day
3 Feb 2015
The ongoing debate about when to get a mammogram and the potential financial cost may hold some women back from getting a life-saving breast cancer screening. This Valentine’s Day, Penn Medicine, The American Cancer Society, and WUVP Univision 65 join forces in “Amate a ti Misma,” or “Love Yourself,” to provide free mammograms to uninsured women in our community.
- Penn Medicine's New Immunotherapy Study Will Pit PD-1 Inhibitor Against Advanced Lung Cancer
3 Feb 2015
Penn Medicine researchers have begun a new immunotherapy trial with the “checkpoint inhibitor” known as pembrolizumab in patients with oligometastatic lung cancer—a state characterized by a few metastases in a confined area—who have completed conventional treatments and are considered free of active disease but remain at a high risk for recurrence.
- Penn Researchers Show Value of Tissue-Engineering to Repair Major Peripheral Nerve Injuries
30 Jan 2015
Peripheral nerve injury (PNI) is a common consequence of traumatic injuries, wounds caused by an external force or an act of violence, such as a car accident, gun shot or even surgery. In those injuries that require surgical reconstruction, outcomes can result in partial or complete loss of nerve function and a reduced quality of life. But, researchers at Penn Medicine have demonstrated a novel way to regenerate long-distance nerve connections in animal models using tissue-engineered nerve grafts (TENGs).
- AHRQ Redesignates ECRI Institute-Penn Medicine as Evidence-based Practice Center
30 Jan 2015
The ECRI Institute-Penn Medicine Evidence-based Practice Center (EPC) was recently redesignated by the Agency for Healthcare Research and Quality (AHRQ) to serve as an EPC through 2019.
- Teaching Doctors in the New Millennium: Penn's Perelman School of Medicine Opens New Home for Medical Education
29 Jan 2015
With the opening of the Henry A. Jordan M’62 Medical Education Center, the Perelman School of Medicine at the University of Pennsylvania has expanded its urban campus with an innovative new facility that’s redefining medical education for 21st century doctors.
- Penn Medicine Study Shows Menopause Does Not Increase or Create Difficulty Sleeping
28 Jan 2015
Women in their late thirties and forties who have trouble sleeping are more than three times more likely to suffer sleep problems during menopause than women who have an easier time getting shut-eye, according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania.
- Study Reveals Possible Therapeutic Target for Common, But Mysterious Brain Blood Vessel Disorder
26 Jan 2015
Tens of millions of people around the world have abnormal, leak-prone sproutings of blood vessels in the brain called cerebral cavernous malformations (CCMs). These abnormal growths can lead to seizures, strokes, hemorrhages, and other serious conditions, yet their precise molecular cause has never been determined. Now, cardiovascular scientists at the Perelman School of Medicine at the University of Pennsylvania have studied this pathway in heart development to discover an important set of molecular signals, triggered by CCM-linked gene defects, that potentially could be targeted to treat the disorder.
- Penn Medicine Selected for Digital 25 Award by IDG Enterprise Media
22 Jan 2015
Penn Medicine received a 2015 Digital Edge 25 Award, produced by IDG Enterprise media brands CIO and Computerworld and the CIO Executive Council. One of 25 recipients nationwide, Penn Medicine is the only academic medical center on the list.
- Penn Study Uncovers Secrets of a Clump-Dissolving Protein
22 Jan 2015
Penn Medicine researchers have discovered that a previously disregarded part of the Hsp104 structure, the N-terminal domain (NTD), located at one end of the Hsp104 molecule, is a major player in its protein-busting powers.
- Penn Medicine Opens Pavilion for Advanced Care, Integrating Critical Care Specialties and Expanding Penn Presbyterian Medical Center Campus
22 Jan 2015
This month, Penn Medicine's new 144 million-dollar facility, the Pavilion for Advanced Care (PAC) at Penn Presbyterian Medical Center (PPMC), opened the doors to its first patients. Clinical teams from critical care specialties, surgical services, trauma/emergency services and radiology have come together in the new six-story, 178,000-square-foot facility.