Perelman School of Medicine at the University of Pennsylvania
Center for Resuscitation Science


Center for Resuscitation Science Research Activities

The Center engages in a wide variety of research, from laboratory investigations to clinical studies to community educational initiatives. These research activities can be categorized by the following broad themes:

  1. Studies in resuscitation performance, CPR training and CPR physiology. Investigators at the Center have made important strides in understanding how to measure and improve on resuscitation performance, including aspects of CPR quality and resuscitation teamwork. In addition, Center investigators study blood flow and physiology during CPR delivery.
  2. Post-arrest care and targeted temperature management (TTM). Center investigators have worked to optimize the delivery of post-arrest care, including hemodyanamics, neuroprognostication, and the role of body temperature in clinical outcomes.  Other work has focused specifically on TTM delivery and its role as part of the "post arrest bundle of care".
  3. Public CPR education, population studies of resuscitation, and networks of care. Studies have focused on such questions as the optimal approaches to CPR education for lay providers, deployment of automated external defibrillators (AEDs) in public spaces, and how to best strengthen the "chain of survival" from a systems perspective. The Center is an active participant in the national HeartRescue Consortium, a multistate effort to improve cardiac arrest outcomes in partnership with a broad coalition of stakeholders within each geographic region.

Recent publications from the Center include:

Resuscitation and CPR

  • Bhardwaj, A., & Abella, B. S. (2015). Does chest compression fraction matter, after all? Resuscitation, doi:S0300-9572(15)00796-0 [pii]
  • Donoghue, A., Hsieh, T. C., Myers, S., Mak, A., Sutton, R., & Nadkarni, V. (2015). Videographic assessment of cardiopulmonary resuscitation quality in the pediatric emergency department. Resuscitation, 91, 19-25. doi:10.1016/j.resuscitation.2015.03.007 [doi]
  • Hsieh, T. C., Wolfe, H., Sutton, R., Myers, S., Nadkarni, V., & Donoghue, A. (2015). A comparison of video review and feedback device measurement of chest compressions quality during pediatric cardiopulmonary resuscitation. Resuscitation, 93, 35-39. doi:10.1016/j.resuscitation.2015.05.022 [doi]
  • Nelson, J., & Abella, B. S. (2015). Improving CPR measurement: Are we there yet? Resuscitation, 87, A1-2. doi:10.1016/j.resuscitation.2014.11.021 [doi]
  • Panchal, A. R., Fishman, J., Camp-Rogers, T., Starodub, R., & Merchant, R. M. (2015). An "intention-focused" paradigm for improving bystander CPR performance. Resuscitation, 88, 48-51. doi:10.1016/j.resuscitation.2014.12.006 [doi]
  • Ranola, P. A., Merchant, R. M., Perman, S. M., Khan, A. M., Gaieski, D., Caplan, A. L., & Kirkpatrick, J. N. (2015). How long is long enough, and have we done everything we should?--ethics of calling codes. Journal of Medical Ethics, 41(8), 663-666. doi:10.1136/medethics-2013-101949 [doi]
  • Sheak, K. R., Wiebe, D. J., Leary, M., Babaeizadeh, S., Yuen, T. C., Zive, D., . . . Abella, B. S. (2015). Quantitative relationship between end-tidal carbon dioxide and CPR quality during both in-hospital and out-of-hospital cardiac arrest. Resuscitation, 89, 149-154. doi:10.1016/j.resuscitation.2015.01.026 [doi]

Post-Arrest Care and TTM

  • Abella, B. S.,Varon, J., Foedisch, M., & Tisherman, S. (2015). Cooling strategies outside the central nervous system. Therapeutic Hypothermia and Temperature Management, 5(3), 116-120. doi:10.1089/ther.2015.29000.bsa [doi]
  • Perman, S. M., Ellenberg, J. H., Grossestreuer, A. V., Gaieski, D. F., Leary, M., Abella, B. S., & Carr, B. G. (2015). Shorter time to target temperature is associated with poor neurologic outcome in post-arrest patients treated with targeted temperature management. Resuscitation, 88, 114-119. doi:10.1016/j.resuscitation.2014.10.018 [doi]

Public Health

  • Gonzalez, M., Leary, M., Blewer, A. L., Cinousis, M., Sheak, K., Ward, M., . . . Abella, B. S. (2015). Public knowledge of automatic external defibrillators in a large U.S. urban community. Resuscitation, 92, 101-106. doi:10.1016/j.resuscitation.2015.04.022 [doi]
  • Merchant, R. M. (2015). Public report cards for in-hospital cardiac arrest: Empowering the public with location-specific data. Circulation, 131(16), 1377-1379. doi:10.1161/CIRCULATIONAHA.115.016023 [doi]
  • Padrez, K. A., Ungar, L., Schwartz, H. A., Smith, R. J., Hill, S., Antanavicius, T., . . . Merchant, R. M. (2015). Linking social media and medical record data: A study of adults presenting to an academic, urban emergency department. BMJ Quality & Safety, doi:bmjqs-2015-004489 [pii]
  • VonHoltz, L. A., Hypolite, K. A., Carr, B. G., Shofer, F. S., Winston, F. K., Hanson, C. W.,3rd, & Merchant, R. M. (2015). Use of mobile apps: A patient-centered approach. Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine, 22(6), 765-768. doi:10.1111/acem.12675 [doi]