Perelman School of Medicine at the University of Pennsylvania

Penn RNA Group

Affiliated Labs

Listed below are many of the labs affiliated with the Penn RNA Group. We come from all schools at the University of Pennsylvania as well as other academic institutions around Philadelphia. Many of us are not necessarily "RNA labs," but rather have specific individuals/projects that are focused on RNA function, RNA-based gene regulation or RNA binding proteins. We welcome you to get to know us and join us!

Alphabetical by PI

Montserrat C. Anguera, PhD
Department of Animal Biology, U Penn School of Veterinary Medicine
We investigate the function and mechanism of long noncoding RNAs during early human development. We are particularly interested in transcripts that regulate X-Chromosome Inactivation, and use pluripotent stem cells as a model system.
Anguera Lab

Yoseph Barash, PhD
Department of Genetics, U Penn Perelman School of Medicine
The BioCiphers lab develops machine learning algorithms that combine genomics and genetic data to study RNA biogenesis and post-transcriptional regulation. A main focus of the lab is developing predictive models for alternative splicing and applying them for studies of human disease and phenotypic diversity.
Barash Lab

Nancy M. Bonini, PhD
Department of Biology, U Penn School of Arts and Sciences
Our laboratory is defining toxicity pathways of RNA binding proteins and small RNA pathways that impact human neurodegenerative disease and brain aging. We launch from Drosophila as an in vivo system, and use genetics, cell biology, molecular biology, genomics and other molecular and cellular techniques to gain insight into key pathways of critical important to the brain normally and in disease.
Bonini Lab

Russ Carstens, MD
Department of Medicine, U Penn Perelman School of Medicine

Sara Cherry, PhD
Department of Microbiology, U Penn Perelman School of Medicine

Beverly Davidson, PhD
Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia
Davidson Lab

Gideon Dreyfuss, PhD
Department of Biochemistry and Biophysics, U Penn Perelman School of Medicine
Dreyfuss Lab

James Eberwine, PhD
Departments of Pharmacology and Psychiatry, U Penn Perelman School of Medicine
My lab utilizes the techniques of genomics, biochemistry, chemistry, molecular biology, imaging and computational biology to study quantitative aspects of RNA function in live single cells. We have developed many of the molecular techniques that permit single cell genomics to be assessed.

Brian D. Gregory, PhD
Department of Biology, U Penn School of Arts and Sciences
We combine classic biochemical approaches with high-throughput sequencing to study RNA secondary structure and RNA-protein interactions genome-wide in eukaryotic organisms.
Gregory Lab

Kathryn E. Hamilton, PhD
Division of GI, Hepatology, and Nutrition, Children’s Hospital of Philadelphia
The Hamilton lab specialize in understanding mechanisms regulating gut homeostasis in health and disease, with a specific interest in how RNA-binding proteins impart global, post-transcriptional regulation of key pathways in normal physiology and pathophysiology of the gastrointestinal tract.
Hamilton Lab

Qihong Huang, MD, PhD
Department of Tumor Microenvironment and Metastasis, The Wistar Institute
Our laboratory utilizes functional genomics approaches to understand the functions of microRNAs and long non-coding RNAs in tumor metastasis and explore the molecular mechanisms of non-coding RNAs in this process.

Stephen A. Liebhaber, MD
Department of Genetics, U Penn Perelman School of Medicine
Our laboratory is exploring the spectrum of post-transcriptional controls mediated by two families of RNA binding proteins; polyC-binding proteins (aCPs, hnRNP Es) and the polyA binding proteins (PABPs). These proteins play critical roles in both nuclear and cytoplasmic controls over RNA processing and cytoplasmic mRNA stability. Our approaches integrate in vitro biochemical studies with cell culture and engineered mouse models in order to explore mechanisms and physiologic impacts of these proteins on mammalian gene expression.

Kristen W. Lynch, PhD
Departments of Biochemistry and Biophysics and Genetics, U Penn Perelman School of Medicine
We combine biochemistry, genomics and molecular biology to study mechanism and consequences of regulated alternative splicing. Our particular emphasis is signal-regulated splicing in human T cells.
Lynch Lab

Zissimos Mourelatos, MD
Department of Pathology, U Penn Perelman School of Medicine
Mourelatos Lab

Kazuko Nishikura, PhD
Department of Gene Expression and Regulation, The Wistar Institute
ADAR (adenosine deaminase acting on RNA) converts adenosine residues into inosine (A-to-I RNA editing). Our research efforts are aimed to better understand the functions of ADAR and the cellular processes regulated by A-to-I RNA editing and to identify possible human diseases caused by malfunction of these processes.
Nishikura Lab

Arjun Raj, PhD
Department of Bioengineering, U Penn School of Engineering and Applied Science
Raj Lab

James Shorter, PhD
Department of Biochemistry and Biophysics, U Penn Perelman School of Medicine
Shorter Lab

Andre Thomas-Tikhonenko, PhD
Division of Cancer Pathobiology, Children's Hospital of Philadelphia

Susan Weiss, PhD
Department of Microbiology, U Penn Perelman School of Medicine
Our lab studies the innate immune response pathways (with a focus on OAS-RNase L) activated during virus infection and by dsRNA generated in the absence of ADAR1 editing.

Matthew Weitzman, PhD
Division of Protective Immunity, Children’s Hospital of Philadelphia
Our lab studies ways in which viruses interact with host cells.  We use biochemistry, molecular and cell biology to probe mechanisms by which viruses overcome host cell defenses by manipulating RNA processing and DNA repair pathways.
Weitzman Lab

Jeremy E. Wilusz, PhD
Department of Biochemistry and Biophysics, U Penn Perelman School of Medicine
We are interested in the mechanisms by which noncoding RNAs are generated, regulated, and function.
Wilusz Lab