Perelman School of Medicine at the University of Pennsylvania

Section for Biomedical Image Analysis (SBIA)

participating with CBICA

Mohamad Habes, PhD


Section of Biomedical Image Analysis
Center for Biomedical Image Computing & Analytics
Department of Radiology
Perelman School of Medicine
University of Pennsylvania

Richards Medical Research Laboratories, Floor 7
3700 Hamilton Walk
Philadelphia, PA 19104
fax: (001) 215.573.1811
Personal page

Bio and research summary

I completed my master’s project in the Institute of Neuroscience and Medicine in Jülich Research Center, Germany. Oct.2014 I obtained my PhD in medical image analysis methods for the aging prospective cohort-based study of Health in Pomerania from the University of Greifswald, Germany. To the end of my PhD, I achieved the Young Scientists Promotion Award to conduct research on the aging brain in the Radiology Department at the University of Pennsylvania. Currently, I am continuing my postdoctoral research at Penn and focusing on brain changes due to aging and Alzheimer’s processes.

In my research I aim to capture subtle brain change for early recognition of aging and neurodegenerative disease effect. I work on developing of advanced machine learning techniques to implement imaging-based markers to capture neurodegenerative related changes in cross-sectional and longitudinal study designs. I am interested in early diagnostic models and brain signatures, that enable better understanding on how brain resilience evolve and multifactorial risk could lead to diverse change.



  • Salti L., Holtfreter B., Pink C., Habes M., Biffar R., Kiliaridis S., Krey K.F., Bülow R., Völzke H., Kocher T. and Daboul A., 'Relationship between Craniofacial Morphology and Gingival Recession and Clinical Attachment Loss', J Clin Periodontol, –accepted-
  • Habes M., Toledo J.B., Resnick S., Doshi J., Van der Auwera S., Erus G., Janowitz D., Hegenscheid K., Homuth G., Völzke H., Hoffmann W., Grabe H.J.§, Davatzikos C.§ 2016, Relationship between APOE Genotype and Structural MRI Measures throughout Adulthood in the Study of Health in Pomerania Population-Based Cohort’. AJNR, vol. 37, no. 9, pp. 1626-1642.
  • Habes M., Janowitz D., Erus G., Toledo J.B., Resnick, S., Doshi J., Van der Auwera, S., Wittfeld, K., Hegenscheid K., Hosten N., Biffar R., Homuth G., Völzke H., Grabe H.J., Hoffmann W., Davatzikos C. 2016, ’Advanced Brain Aging: relationship with epidemiologic and genetic risk factors, and overlap with Alzheimer disease atrophy patterns’. Transl Psychiatry, vol. 6, pp. e775. doi: 10.1038/tp.2016.39.
  • **Habes M., Erus G., Toledo J.B., Zhang T., Bryan N, Launer L. J., Rosseel Y., Janowitz D., Doshi J., Van der Auwera S., von Sarnowski B., Hegenscheid K., Hosten N., Homuth G., Völzke H., Schminke U., Hoffmann W., Grabe H.J.§, Davatzikos, C.§ 2016, 'White matter hyperintensities and imaging patterns of brain aging in the general population'. Brain, vol. 139, no. 4, pp. 1164-79. doi: 10.1093/brain/aww008
  • Grabe H.J., Wittfeld K., Van der Auwera S., Janowitz D., Hegenscheid K., Habes M., Homuth G., Barnow S., John U., Nauck M. and Völzke H., Meyer zu Schwabedissen H., Freyberger H.J., Hosten N., 2016, 'Effect of the interaction between childhood abuse and rs1360780 of the FKBP5 gene on gray matter volume in a general population sample'. Human Brain Mapping, vol. 37, no. 4, pp. 1602-13
  • Adams H.H., Hilal S., Schwingenschuh P., Wittfeld K., van der Lee S.J., DeCarli C., Vernooij M.W., Katschnig-Winter P., Habes M., Chen C. and Seshadri S., van Duijn, C. M., Ikram M.K., Grabe H.J., Schmidt R., Ikram M. A., 2015, 'A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium'. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, vol.1, no. 4, pp. 513-520.
  • Janowitz D., Wittfeld K., Terock J., Freyberger H.J., Hegenscheid K., Völzke H., Habes M., Hosten N., Friedrich N., Nauck M., Domanska G., Grabe H.J., 2015, 'Association between waist circumference and gray matter volume in 2344 individuals from two adult community-based samples'. Neuroimage, vol. 122, pp. 149-157.
  • Verhaaren B., Debette S., Bis J., … Habes M., ... , Fornage M., 2015, 'Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI'. Circulation: Cardiovascular Genetics: Circgenetics, vol. 114.
  • Janowitz D., Schwahn C., Borchardt U., Wittfeld K., Schulz A., Barnow S., Biffar R., Hoffmann W., Habes M., Homuth G., Nauck M., Hegenscheid K., Lotze M., Völzke H., Freyberger H.J., Debette S., Grabe, H.J., 2014, 'Genetic, psychosocial and clinical factors associated with hippocampal volume in the general population', Translational psychiatry, vol. 4, no. 10, pp. e465.
  • Habes M., Bahr J., Schiller T., Kühn J. P., Hoppe L., Burchardt M. and Hoffmann W., 2014, 'New technique for prostate volume assessment', World journal of urology, vol. 32, no 6 ,pp. 1559-1564.
  • Habes M., Schiller T., Rosenberg C., Burchardt M. and Hoffmann W., 2013, 'Automated prostate segmentation in whole-body MRI scans for epidemiological studies', Physics in Medicine and Biology, vol. 58, no. 17, pp. 5899-5915.
  • Habes M., Rota Kops E., Bahr J., Kühn J.P., Hoffmann W., Lipinski H-G and Herzog H., 2013, 'Automated Skull and Cavity Segmentation from Ultra Short TE Sequence Images', Current Medical Imaging Reviews, vol. 9, no. 2, pp. 120-12
  • Daboul A., Schwahn C., Schaffner G., Soehnel S., Samietz S., Aljaghsi A., Habes M., Hegenscheid K., Puls R., Klinke T., and Biffar R., 2012, 'Reproducibility of Frankfort Horizontal Plane on 3D Multi-Planar Reconstructed MR Images', PLoS ONE, vol. 7, no. 11
  • Meyer J., Fredrich D., Piegsa J., Habes M., van den Berg N. and Hoffmann W., 2012, 'A mobile and asynchronous electronic data capture system for epidemiologic studies', Computer Methods and Programs in Biomedicine, vol. 110, no. 3, pp. 369-379