Perelman School of Medicine at the University of Pennsylvania

Section for Biomedical Image Analysis (SBIA)

participating with CBICA


The overarching goal of the project is to create a robust validated tractography that will address the issue of edema and mass effect that plague current surgical planning tools. In the process we are developing an edema invariant tractography paradigm that combines a multi-compartment HARDI model with anatomically and functionally constrained probabilistic fiber tracking. This will be evaluated for reliability and replicability using a software phantom, as well as validated using direct electrical stimulation and task-based fMRI.



Collaborators: Steven Brem, Timothy Lucas, Mark Elliott, Maxime Descoteaux, Emmanuel Caruyer

  1. Jérémy Lecoeur, Emmanuel Caruyer, Luke Macyszyn, Ragini Verma. Improving White Matter Tractography by Resolving the Challenges of Edema. MICCAI 2013 DTI Tractography Challenge, Sep 2013, Nagoya, Japan. 2013. <hal-00850496>
  2. Jérémy Lecoeur, Emmanuel Caruyer, Mark Elliott, Steven Brem, Luke Macyszyn, et al.. Addressing the Challenge of Edema in Fiber Tracking. MICCAI 2014 DTI Tractography Challenge, Sep 2014, Boston, United States. 2014. <hal-01072222>