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The Structural Biology Program (SBP) at the Perelman School of Medicine (PSOM) aims to nucleate numerous research groups interested in using structural biology to address fundamental questions relevant to human health, which would lead to major novel advances in basic and translational research.

Formation of this new Program at PSOM reflects the convergence of technological advances in instrumentation and approaches to solve structures of biological molecules, an increased appreciation for structural biology in fundamental and translational biomedical science, and a growing community of users of these technologies at Penn.  This Program, a joint effort of the Departments of Biochemistry and Biophysics and Systems Pharmacology and Translational Therapeutics together with PSOM will highlight the use of cryo electron microscopy (cryo-EM) and other cutting-edge approaches and provide accessible technology and intellectual support to the broader Penn community. This new Program will catalyze novel advances in the areas of structural biology and will meet structural biology needs on the UPenn campus. 

Announcements

New Structure Biology Program

Announce the formation of a new Structural Biology Program established in the Perelman School of Medicine (PSOM) led by Dr. Vera Moiseenkova-Bell, Professor, SPATT.

Read More About the New Structure Biology Program

The New Institute For Structural Biology (ISB)

Collaborations & Resources

SBP offers a wide array of core facilities and other technologies, including a FEI Titan Krios cryo-electron microscope. Members of the Structural Biology Program derive particular benefit from close ties to the following:

For Students & Post-Docs

Recent Publications

A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria.

The Journal of antimicrobial chemotherapy. 2023 Sep 6; Authors: Chen Y, Yong M, Li M, Si Z, Koh CH, Lau P, Chang YW, Teo J, Chan-Park MB, Gan YH

Visualizing the membrane disruption action of antimicrobial peptides by cryo-electron tomography.

Nature communications. 2023 Sep 6;14(1):5464; Authors: Chen EH, Wang CH, Liao YT, Chan FY, Kanaoka Y, Uchihashi T, Kato K, Lai L, Chang YW, Ho MC, Chen RP