Publications | Susztak Lab | Perelman School of Medicine at the University of Pennsylvania

Transcription factor TBX2 is a key regulator of vascular calcification.

European heart journal. 2026 Oct 6;

Authors: Li S, Liu H, Lee S, Ha E, Dumoulin B, Palmer MB, Miller CL, Damrauer SM, Malhotra R, Susztak K

Cardiovascular-kidney-metabolic syndrome as a mitochondrial systems disorder.

Nature reviews. Nephrology. 2026 Sep 24;

Authors: Li S, Abel ED, Arany Z, Baur JA, Pei L, Susztak K

The Role of Angiopoietin-Like Proteins 3 and 4 and Their Target Lipases in CKD: A Drug-Target Mendelian Randomization Study.

American journal of kidney diseases : the official journal of the National Kidney Foundation. 2026 Sep 22;

Authors: Yang G, Zhang DY, Fischman CJ, Cuchel M, Susztak K, Rader DJ

Nucleic acid sensing pathways in kidney disease development.

Nature reviews. Nephrology. 2026 Sep 1;

Authors: Andrade-Silva M, Kang C, Jang Y, Susztak K

Improving the histologic classification of advanced diabetic nephropathy based on the Transformative Research in Diabetic Nephropathy (TRIDENT) findings.

Kidney international. 2026 Aug 26;

Authors: Mohandes S, Nast CC, Mottl A, Scialla J, Almaani S, Luciano R, Isakova T, Ellis C, Bansal S, Argyropoulos C, Jennette JC, Gasim A, Stillman IE, Campbell KN, Abedini A, Coppock G, TRIDENT Consortium, Susztak K, Palmer MB

Inherited Susceptibility to Urinary Tract Infections from Kidney Papilla to Bladder.

medRxiv : the preprint server for health sciences. 2026 Aug 24;

Authors: Xu K, Khan A, Shang N, Zeng W, Wang C, Berrouet C, Shen TH, Narayanan P, Deng J, DiPerna C, Williams C, Cuacuas S, Olsen TR, Arace J, Ghotra A, Guo TW, Monical W, Borisov O, Haug S, Liu H, Ha E, Yaeh A, Banlengchit R, Levitman A, Halibart B, Patel D, Chou C, Simmons S, Goswami S, Nesanir K, Fujita M, Kullo IJ, Jarvik GP, Wei WQ, Feng Q, Jiang L, Stein CM, Weng C, Hripcsak G, Gharavi AG, Susztak K, De Jager PL, Köttgen A, Barasch J, Sims PA, Kiryluk K

Response by Poudel and Susztak to Letter Regarding Article, "Cell-Specific Inducible Human APOL1 Risk Variant Expression in Mice Causes Hypertension and Renal Damage".

Circulation. 2026 Aug 11;154(6):e237-e238 Epub 2026 Aug 10;

Authors: Poudel B, Susztak K

Marginal zone B cell targeting limits alloantigen availability to follicular dendritic cells and mitigates antibody-mediated rejection.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2026 Aug 11;

Authors: Gassen RB, Liu K, Ganchiku Y, Lima K, Al Jurdi A, Susztak K, Magee CN, Murakami N, Rosales IA, Borges TJ, Riella LV

Percutaneous Native Kidney Biopsy Complications in Diabetic Patients in the TRIDENT Cohort.

Clinical journal of the American Society of Nephrology : CJASN. 2026 Aug 1;21(8):1376-1385 Epub 2026 Jun 15;

Authors: Mohandes S, Fakhreddine M, Sheng H, Al Dulaimee M, Mottl A, Scialla J, Almaani S, Luciano R, Isakova T, Bansal S, Argyropoulos C, Avasare R, Singh M, Campbell KN, Townsend R, Coppock G, Palmer M, Susztak K, TRIDENT Consortium

Single-cell spatial mapping of human kidney development implicates the microenvironment in guiding cell fate decisions.

Nature genetics. 2026 Aug;58(8):1877-1890 Epub 2026 Jul 30;

Authors: Levinsohn J, Grindel S, Dumoulin B, Abedini A, Conte C, Huang AZ, Levin-Klein R, Weisz B, Rabinowitz G, Bergeson AM, Ha E, Klötzer KA, Zhang N, Titchenell P, Li M, Park JS, Arroyo JP, Finn LS, Sasaki K, Beckerman P, Pleniceanu O, Romagnani P, Hughes AJ, Susztak K

ELF3 links kidney function GWAS loci to maladaptive epithelial inflammation.

Science advances. 2026 Jul 24;12(30):eaec6741;

Authors: Hou Y, Kloetzer K, Dumoulin B, Ha E, Liu H, Mukhi D, Andrade-Silva M, Hu X, Pan S, Susztak K

Single-Cell Resolution Drug Effects of Renin-Angiotensin-Aldosterone Blockade in ZSF1 Rat Diabetic Kidney Disease.

Journal of the American Society of Nephrology : JASN. 2026 Jul 1;37(7):1438-1456 Epub 2026 Jan 7;

Authors: Balzer MS, Zhou J, Abedini A, Ma Z, Hou Y, Yadav T, Grundmann M, Pavkovic M, Susztak K

ACLY-Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation-Associated Fibrosis in Chronic Kidney Disease.

Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2026 Jul;13(37):e75247 Epub 2026 Apr 16;

Authors: Du C, Mukhi D, Li L, Li C, Pan S, Dumoulin B, Ha E, Kolligundla LP, Hou Y, Levinsohn J, Kang C, Klötzer KA, Wu J, Mohandes S, Wellen KE, Susztak K

Cross-Modality Alignment of Spatial Transcriptomics, Multiplexed Imaging, and Histology with PHARAOH.

Research square. 2026 Jun 19;

Authors: Yao S, Jing Z, Jiang S, Li W, Yamamoto Y, Dumoulin B, Sachs N, Maegdefessal L, Susztak K, Wang L, Kadara H, Li M

Spatial atlas of diabetic kidney disease reveals a B cell-rich subgroup.

Nature. 2026 May;653(8116):1158-1169 Epub 2026 Apr 29;

Authors: Dumoulin B, Levinsohn J, Klötzer KA, Li C, Mao L, Ha E, Mohandes S, Nguyen T, Paruzzo L, Hirohama D, Fang V, Bhoj VG, Parhiz H, Andrade-Silva M, Abedini A, Bergeson A, Traum D, May MJ, Kaestner KH, Ruella M, McAllister FE, Hakimi AA, Li M, Palmer M, Wherry EJ, Hunter CA, Cancro MP, TRIDENT consortium, Susztak K

KDM1A regulates nephron progenitor programs and is associated with human kidney disease risk.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2026 May 1;

Authors: Kolligundla LP, Mukhi D, Levinsohn J, Bergerson A, Hou Y, Liu H, Capell BC, Susztak K

Proteomic risk score for early prediction of kidney disease progression in individuals with APOL1 high-risk genotypes.

Nature medicine. 2026 May;32(5):1701-1707 Epub 2026 Apr 15;

Authors: Li C, Richards SM, Quinn G, Abedini A, Zhu M, Verma T, Mohandes S, Pitts R, Barros V, Qiu X, Shin T, Loureiro JJ, Finkel N, Surapaneni A, Coresh J, Grams ME, Karihaloo A, Li H, Verma A, Ritchie M, Rader DJ, Penn Medicine BioBank, Dietrich WF, Jennings LL, Susztak K

Response to the Letter to the Editor Entitled "A Missing Genomic Dimension: The Small but Central Mitochondrial Genome in Diabetic Kidney Disease Genetics".

Kidney international reports. 2026 Jul;11(7):106572 Epub 2026 Apr 29;

Authors: Sandholm N, Cole JB, Nair V, Brennan E, Giardini E, Haukka JK, Ha E, Syreeni A, Dahlström EH, Salem RM, Fermin D, Mercader J, Smyth L, Hill C, Mychaleckyj J, McGurnaghan S, Miller RG, Costacou T, Snell-Bergeon J, Paterson AD, Verkauskiene R, Sokolovska J, Panduru NM, Zerbini G, Brismar K, Krolewski AS, Harjutsalo V, Rossing P, Hadjadj S, McKay G, McKnight AJ, Maxwell AP, Susztak K, Godson C, Kretzler M, Hirschhorn JN, Florez JC, Groop PH, GENIE Consortium

HNF1B integrates signals in a feed-forward loop driving kidney disease progression.

Science (New York, N.Y.). 2026 Apr 16;392(6795):eaea3219;

Authors: Isnard P, Makinistoglu MP, Leibovici M, Levinsohn J, Zimmermann N, Cohen C, Garbay S, Nguyen C, Gaglioti D, Chiral M, Grevellec-Christophorou A, Fiorentino A, Peters DJM, Fischer E, Bienaimé F, Susztak K, Terzi F, Pontoglio M

Multiscale confidence quantification for virtual spatial transcriptomics with UTOPIA.

bioRxiv : the preprint server for biology. 2026 Mar 3;

Authors: Jin K, Chen Z, Yu X, Yuan M, Schroeder A, Dumoulin B, Liu Y, Wang L, Park JH, Hwang TH, Susztak K, Ren Z, Zhang NR, Li M

Inflammation-Driven Field Cancerization in End-Stage Kidney Disease.

Cancer discovery. 2026 Mar 2;16(3):426-427;

Authors: Sager RA, Susztak K, Hakimi AA

Pixel2Gene enables histology-guided reconstruction and prediction of spatial gene expression.

bioRxiv : the preprint server for biology. 2026 Feb 23;

Authors: Yao S, Schroeder A, Jiang S, Im S, Park JH, Dumoulin B, Hwang TH, Susztak K, Li M

Cell-Specific Inducible Human APOL1 Risk Variant Expression in Mice Causes Hypertension and Renal Damage.

Circulation. 2026 Feb 10;153(6):396-414 Epub 2025 Dec 11;

Authors: Li F, Poudel B, Andrade-Silva M, Wu J, Raman A, Cruz-Morales E, Wahba J, Vassalotti A, Li C, Abedini A, Klötzer KA, Ding X, Hunter CA, Miner JJ, Susztak K

Platform-dependent effects of genetic variants on plasma APOL1.

iScience. 2026 Mar 20;29(3):114953 Epub 2026 Feb 7;

Authors: Wang QS, Huang J, Chan LJG, Haste N, Olsson N, Gaun A, McAllister FE, Madhireddy D, Baruch A, Cardone KM, Kumar R, Ritchie M, Susztak K, Melamud E, Baryshnikova A

HistoSweep enables cellular-resolution tissue quality control for gigapixel images in digital pathology and spatial omics.

bioRxiv : the preprint server for biology. 2026 Feb 2;

Authors: Schroeder A, Yu X, Li W, Yuan M, Mao L, Yang J, Sachs N, Dumoulin B, Xu GX, Luo X, Huang A, Susztak K, Hwang TH, Kadara H, Maegdefessel L, Yu J, Li M

Spatial metabolomics and multiomics integration for breakthroughs in precision medicine for kidney disease.

Nature reviews. Nephrology. 2026 Feb;22(2):152-164 Epub 2025 Oct 9;

Authors: Sharma K, Hansen J, Susztak K, Eberlin L, Anderton CR, Alexandrov T, Iyengar R

Mechanisms of diabetic kidney disease and established and emerging treatments.

Nature reviews. Endocrinology. 2026 Jan;22(1):21-35 Epub 2025 Sep 11;

Authors: Martinez Leon V, Hilburg R, Susztak K

Author Correction: Mechanisms of diabetic kidney disease and established and emerging treatments.

Nature reviews. Endocrinology. 2026 Jan;22(1):61;

Authors: Martinez Leon V, Hilburg R, Susztak K

Smart spatial omics (S2-omics) optimizes region of interest selection to capture molecular heterogeneity in diverse tissues.

Nature cell biology. 2025 Dec;27(12):2225-2238 Epub 2025 Nov 26;

Authors: Yuan M, Jin K, Yan H, Schroeder A, Luo C, Yao S, Dumoulin B, Levinsohn J, Luo T, Clemenceau JR, Jang I, Kim M, Liu Y, Deng M, Furth EE, Wilson P, Nayak A, Lubo I, Solis Soto LM, Wang L, Park JH, Susztak K, Hwang TH, Li M

Genetic determinants of zinc homeostasis and its role in cardiometabolic diseases.

PLoS genetics. 2025 Dec;21(12):e1011928 Epub 2025 Dec 1;

Authors: Sadler MC, Ghobril JP, Borisov O, Perrais M, Schiano G, Petrovic D, Ha E, Ponte B, Li Y, Rodriguez-Hernandez Z, Pruijm M, Ackermann D, Guessous I, Stringhini S, Ehret G, Corre T, Vogt B, Martin PY, Ongen H, Dermitzakis E, Williams JE, Murdoch BM, McGuire MK, Meehan CL, INSPIRE Consortium, Lenglet S, Susztak K, Vaucher J, Thomas A, Devuyst O, Köttgen A, Bochud M, Kutalik Z

Recovery of biological signals lost in single-cell batch integration with CellANOVA.

Nature biotechnology. 2025 Nov;43(11):1861-1877 Epub 2024 Nov 26;

Authors: Zhang Z, Mathew D, Lim TL, Mason K, Martinez CM, Huang S, Wherry EJ, Susztak K, Minn AJ, Ma Z, Zhang NR

APOL1 kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Kidney international. 2025 Nov;108(5):763-779 Epub 2025 Jun 23;

Authors: Ojo AO, Adu D, Bramham K, Freedman BI, Gbadegesin RA, Ilori TO, Jefferson N, Olabisi OA, Susztak K, Young BA, Cheung M, King JM, Grams ME, Jadoul M, Ulasi II, Conference Participants

The proteogenomic landscape of the human kidney and implications for cardio-kidney-metabolic health.

Nature medicine. 2025 Nov;31(11):3917-3929 Epub 2025 Aug 12;

Authors: Hirohama D, Fadista J, Ha E, Liu H, Abedini A, Levinsohn J, Vassalotti A, Zeng L, Li C, Mohandes S, Vitale S, Shungin D, Nguyen T, Niewczas MA, Olsson N, McAllister FE, Karihaloo A, Susztak K

Two decades of nephrology research: progress and future challenges.

Nature reviews. Nephrology. 2025 Nov;21(11):727-735 Epub 2025 Sep 19;

Authors: Anandh U, Anders HJ, Bacchetta J, Johnson DW, Luyckx V, Remuzzi G, Rodriguez-Iturbe B, Susztak K, Tuttle K, Yanagita M

Exome-Wide Analysis Identifies a Rare EXD3 Missense Variant Associated With Diabetic Kidney Disease.

Kidney international reports. 2026 Jan;11(1):219-232 Epub 2025 Oct 22;

Authors: Sandholm N, Cole JB, Nair V, Brennan E, Giardini E, Haukka JK, Ha E, Syreeni A, Dahlström EH, Salem RM, Fermin D, Mercader J, Smyth L, Hill C, Mychaleckyj J, McGurnaghan S, Miller RG, Costacou T, Klein BEK, Snell-Bergeon J, Paterson AD, Verkauskiene R, Sokolovska J, Panduru NM, Zerbini G, Brismar K, Krolewski AS, Harjutsalo V, Rossing P, Hadjadj S, McKay G, McKnight AJ, Maxwell AP, Susztak K, Godson C, Kretzler M, Hirschhorn JN, Florez JC, Groop PH, GENIE Consortium

Unbiased self supervised learning of kidney histology reveals phenotypic and prognostic insights.

Scientific reports. 2025 Oct 8;15(1):35131;

Authors: Pandit K, Coudray N, Quiros AC, Surapaneni A, Upadhyay D, Vanguri RS, Hirohama D, Mohandes S, Schlosser P, Thiessen-Philbrook H, Wen Y, Parikh CR, Rhee EP, Waikar SS, Schmidt I, Rosenberg AZ, Palmer MB, Susztak K, Grams ME, Tsirigos A, TRIDENT Study Investigators

From form to function: New heights in kidney organoids.

Cell stem cell. 2025 Oct 2;32(10):1485-1486;

Authors: Levinsohn J, Susztak K

Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre-mRNA.

Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2025 Oct;12(40):e06707 Epub 2025 Aug 20;

Authors: Li C, Marschner JA, Kusunoki Y, Zhang N, Li X, Deng H, Zhao Z, Watanabe-Kusunoki K, Zhu Z, Xu Y, Steiger S, Lech M, Susztak K, Schulz C, Anders HJ

Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci.

Journal of the American Society of Nephrology : JASN. 2025 Oct 1;36(10):1939-1953 Epub 2025 May 5;

Authors: Cole JB, Dahlström EH, Fermin D, Gupta Y, Hill C, Smyth LJ, Liu H, Kreienkamp RJ, Pezzolesi MG, Cao JJ, Valo E, Chen WM, Onengut-Gumuscu S, Rich SS, Brennan EP, Andrews D, Kennedy C, Gu HF, Stechemesser L, Weitgasser R, Sokolovska J, Radzeviciene L, Verkauskiene R, Panduru NM, Rossing P, Ahluwalia TS, Zerbini G, Marre M, Hadjadj S, Costacou T, Miller RG, Klein BE, Lee KE, Snell-Bergeon JK, Caramori ML, Mauer M, Brismar K, Bjornstad P, McKnight AJ, McKay G, Nair V, Salem RM, Groop PH, Godson C, Susztak K, Kretzler M, Maxwell AP, Krolewski A, Paterson A, Sandholm-Lafferre N, Florez JC, Hirschhorn JN

Nephrobase Cell+: Multimodal Single-Cell Foundation Model for Decoding Kidney Biology.

bioRxiv : the preprint server for biology. 2025 Oct 1;

Authors: Li C, Ziyadeh E, Sharma Y, Dumoulin B, Levinsohn J, Ha E, Pan S, Rao V, Subramaniyam M, Szegedy M, Zhang N, Susztak K

Nephrobase Cell+: Multimodal Single-Cell Foundation Model for Decoding Kidney Biology.

ArXiv. 2025 Sep 30;

Authors: Li C, Ziyadeh E, Sharma Y, Dumoulin B, Levinsohn J, Ha E, Pan S, Rao V, Subramaniyam M, Szegedy M, Zhang N, Susztak K

Designing smart spatial omics experiments with S2Omics.

bioRxiv : the preprint server for biology. 2025 Sep 21;

Authors: Yuan M, Jin K, Yan H, Schroeder A, Luo C, Yao S, Domoulin B, Levinsohn J, Luo T, Clemenceau JR, Jang I, Kim M, Liu Y, Deng M, Furth EE, Wilson P, Nayak A, Lubo I, Soto LMS, Wang L, Park JH, Susztak K, Hwang TH, Li M

Urinary Complement proteome strongly linked to diabetic kidney disease progression.

Nature communications. 2025 Aug 7;16(1):7291;

Authors: Md Dom ZI, Moon S, Satake E, Hirohama D, Palmer ND, Lampert H, Ficociello LH, Abedini A, Fernandez K, Liang X, Pickett S, Levinsohn J, O'Neil K, Dillon ST, Mauer M, Galecki AT, Freedman BI, Susztak K, Doria A, Krolewski AS, Niewczas MA

Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas.

Nature genetics. 2025 Aug;57(8):1922-1934 Epub 2025 Aug 7;

Authors: Klötzer KA, Abedini A, Li S, Balzer MS, Liang X, Levinsohn J, Ha E, Dumoulin B, Hogan JJ, Quinn G, Bloom RD, Schuller M, Eller K, Halmos B, Zhang NR, Susztak K

Platform-dependent effects of genetic variants on plasma APOL1.

bioRxiv : the preprint server for biology. 2025 Apr 29;

Authors: Wang QS, Huang J, Chan L, Haste N, Olsson N, Gaun A, McAllister F, Madhireddy D, Baruch A, Cardone KM, Kumar R, Ritchie M, Susztak K, Melamud E, Baryshnikova A

Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis.

Science translational medicine. 2025 Apr 23;17(795):eadn3079;

Authors: Kolligundla LP, Sullivan KM, Mukhi D, Andrade-Silva M, Liu H, Guan Y, Gu X, Wu J, Doke T, Hirohama D, Guarnieri P, Hill J, Pullen SS, Kuo J, Inamoto M, Susztak K

The actin and microtubule network regulator WHAMM is identified as a key kidney disease risk gene.

Cell reports. 2025 Apr 22;44(4):115462 Epub 2025 Mar 25;

Authors: Mukhi D, Kolligundla LP, Doke T, Silva MA, Liu H, Palmer M, Susztak K

SNA-modified antisense oligonucleotides: A new pathway for renal targeting?

Molecular therapy. Nucleic acids. 2025 Mar 11;36(1):102476 Epub 2025 Feb 17;

Authors: Dumoulin B, Yamada K, Susztak K

Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants.

Science (New York, N.Y.). 2025 Feb 7;387(6734):eadp4753;

Authors: Liu H, Abedini A, Ha E, Ma Z, Sheng X, Dumoulin B, Qiu C, Aranyi T, Li S, Dittrich N, Chen HC, Tao R, Tarng DC, Hsieh FJ, Chen SA, Yang SF, Lee MY, Kwok PY, Wu JY, Chen CH, Khan A, Limdi NA, Wei WQ, Walunas TL, Karlson EW, Kenny EE, Luo Y, Kottyan L, Connolly JJ, Jarvik GP, Weng C, Shang N, Cole JB, Mercader JM, Mandla R, Majarian TD, Florez JC, Haas ME, Lotta LA, Regeneron Genetics Center‡, GHS-RGC DiscovEHR Collaboration§, Drivas TG, Penn Medicine BioBank¶, Vy HMT, Nadkarni GN, Wiley LK, Wilson MP, Gignoux CR, Rasheed H, Thomas LF, Åsvold BO, Brumpton BM, Hallan SI, Hveem K, Zheng J, Hellwege JN, Zawistowski M, Zöllner S, Franceschini N, Hu H, Zhou J, Kiryluk K, Ritchie MD, Palmer M, Edwards TL, Voight BF, Hung AM, Susztak K, Regeneron Genetics Center, GHS-RGC DiscovEHR Collaboration, Penn Medicine BioBank

The critical role of endoplasmic reticulum stress and the stimulator of interferon genes (STING) pathway in kidney fibrosis.

Kidney international. 2025 Feb;107(2):302-316 Epub 2024 Nov 19;

Authors: Andrade-Silva M, Dhillon P, Sanchez-Navarro A, Mukhi D, Hu H, Kolligundla LP, Bergeson A, Abedini A, Levinsohn J, Dumoulin B, Câmara NOS, Miner JJ, Susztak K

Mitochondrial dysfunction has a central role in diabetic kidney disease.

Nature reviews. Nephrology. 2025 Feb;21(2):77-78;

Authors: Li S, Susztak K

Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome.

Cell metabolism. 2025 Jan 7;37(1):154-168.e7 Epub 2024 Nov 18;

Authors: Li S, Liu H, Hu H, Ha E, Prasad P, Jenkins BC, Das US, Mukherjee S, Shishikura K, Hu R, Rader DJ, Pei L, Baur JA, Matthews ML, FitzGerald GA, McReynolds MR, Susztak K

Plasma Transcriptome Profile Associated with Chronic Kidney Disease Progression.

American journal of nephrology. 2025;56(3):296-308 Epub 2024 Dec 18;

Authors: Srivastava A, Maienschein-Cline M, Amdur RL, Susztak K, Kopp JB, Cao H, Shankaranarayanan D, Abdalla Y, Pabalan A, Gombert M, Raj D

A Novel Role for FERM Domain-Containing Protein 3 in CKD.

Kidney360. 2024 Dec 1;5(12):1799-1812 Epub 2024 Oct 16;

Authors: Kennedy C, Doyle R, Gough O, Mcevoy C, McAnallen S, Hughes M, Sheng X, Crifo B, Andrews D, Gaffney A, Rodriguez J, Kennedy S, Dillon E, Crean D, Zhang W, Yi Z, Nair V, Susztak K, Hirschhorn J, Florez J, Groop PH, Sandholm N, Kretzler M, McKay GJ, McKnight AJ, Maxwell AP, Matallanas D, Dorman A, Martin F, Conlon PJ, Sadlier DM, Brennan E, Godson C, Genie Consortium

Is IgA Class Switching Epigenetically Wired?: Untangling the Evidence.

Journal of the American Society of Nephrology : JASN. 2024 Dec 1;35(12):1630-1632 Epub 2024 Nov 5;

Authors: Quinn GZ, Susztak K

Genetic Insights into Blood Pressure From Kidney Multi-Omics.

American journal of kidney diseases : the official journal of the National Kidney Foundation. 2024 Dec;84(6):787-790 Epub 2024 Jul 8;

Authors: Li C, Susztak K

TET2 germline variants promote kidney disease by impairing DNA repair and activating cytosolic nucleotide sensors.

Nature communications. 2024 Nov 7;15(1):9621;

Authors: Liang X, Liu H, Hu H, Ha E, Zhou J, Abedini A, Sanchez-Navarro A, Klötzer KA, Susztak K

A genome-wide association analysis reveals new pathogenic pathways in gout.

Nature genetics. 2024 Nov;56(11):2392-2406 Epub 2024 Oct 15;

Authors: Major TJ, Takei R, Matsuo H, Leask MP, Sumpter NA, Topless RK, Shirai Y, Wang W, Cadzow MJ, Phipps-Green AJ, Li Z, Ji A, Merriman ME, Morice E, Kelley EE, Wei WH, McCormick SPA, Bixley MJ, Reynolds RJ, Saag KG, Fadason T, Golovina E, O'Sullivan JM, Stamp LK, Dalbeth N, Abhishek A, Doherty M, Roddy E, Jacobsson LTH, Kapetanovic MC, Melander O, Andrés M, Pérez-Ruiz F, Torres RJ, Radstake T, Jansen TL, Janssen M, Joosten LAB, Liu R, Gaal OI, Crişan TO, Rednic S, Kurreeman F, Huizinga TWJ, Toes R, Lioté F, Richette P, Bardin T, Ea HK, Pascart T, McCarthy GM, Helbert L, Stibůrková B, Tausche AK, Uhlig T, Vitart V, Boutin TS, Hayward C, Riches PL, Ralston SH, Campbell A, MacDonald TM, FAST Study Group, Nakayama A, Takada T, Nakatochi M, Shimizu S, Kawamura Y, Toyoda Y, Nakaoka H, Yamamoto K, Matsuo K, Shinomiya N, Ichida K, Japan Gout Genomics Consortium, Lee C, Asia Pacific Gout Consortium, Bradbury LA, Brown MA, Robinson PC, Buchanan RRC, Hill CL, Lester S, Smith MD, Rischmueller M, Choi HK, Stahl EA, Miner JN, Solomon DH, Cui J, Giacomini KM, Brackman DJ, Jorgenson EM, GlobalGout Genetics Consortium, Liu H, Susztak K, 23andMe Research Team, Shringarpure S, So A, Okada Y, Li C, Shi Y, Merriman TR

Publisher Correction: A genome-wide association analysis reveals new pathogenic pathways in gout.

Nature genetics. 2024 Nov;56(11):2577;

Authors: Major TJ, Takei R, Matsuo H, Leask MP, Sumpter NA, Topless RK, Shirai Y, Wang W, Cadzow MJ, Phipps-Green AJ, Li Z, Ji A, Merriman ME, Morice E, Kelley EE, Wei WH, McCormick SPA, Bixley MJ, Reynolds RJ, Saag KG, Fadason T, Golovina E, O'Sullivan JM, Stamp LK, Dalbeth N, Abhishek A, Doherty M, Roddy E, Jacobsson LTH, Kapetanovic MC, Melander O, Andrés M, Pérez-Ruiz F, Torres RJ, Radstake T, Jansen TL, Janssen M, Joosten LAB, Liu R, Gaal OI, Crişan TO, Rednic S, Kurreeman F, Huizinga TWJ, Toes R, Lioté F, Richette P, Bardin T, Ea HK, Pascart T, McCarthy GM, Helbert L, Stibůrková B, Tausche AK, Uhlig T, Vitart V, Boutin TS, Hayward C, Riches PL, Ralston SH, Campbell A, MacDonald TM, FAST Study Group, Nakayama A, Takada T, Nakatochi M, Shimizu S, Kawamura Y, Toyoda Y, Nakaoka H, Yamamoto K, Matsuo K, Shinomiya N, Ichida K, Japan Gout Genomics Consortium, Lee C, Asia Pacific Gout Consortium, Bradbury LA, Brown MA, Robinson PC, Buchanan RRC, Hill CL, Lester S, Smith MD, Rischmueller M, Choi HK, Stahl EA, Miner JN, Solomon DH, Cui J, Giacomini KM, Brackman DJ, Jorgenson EM, GlobalGout Genetics Consortium, Liu H, Susztak K, 23andMe Research Team, Shringarpure S, So A, Okada Y, Li C, Shi Y, Merriman TR

Proteomics and Incident Kidney Failure in Individuals With CKD: The African American Study of Kidney Disease and Hypertension and the Boston Kidney Biopsy Cohort.

Kidney medicine. 2024 Dec;6(12):100921 Epub 2024 Oct 16;

Authors: Chen TK, Surapaneni AL, Schmidt IM, Waikar SS, Coresh J, Liu H, Susztak K, Rhee EP, Liu C, Schlosser P, Grams ME

Single-Nucleus RNA Sequencing Reveals Loss of Distal Convoluted Tubule 1 Renal Tubules in HIV Viral Protein R Transgenic Mice.

The American journal of pathology. 2024 Oct;194(10):1844-1856 Epub 2024 Jul 18;

Authors: Latt KZ, Yoshida T, Shrivastav S, Abedini A, Reece JM, Sun Z, Lee H, Okamoto K, Dagur P, Ishimoto Y, Heymann J, Zhao Y, Chung JY, Hewitt S, Jose PA, Lee K, He JC, Winkler CA, Knepper MA, Kino T, Rosenberg AZ, Susztak K, Kopp JB

METTL3-Mediated N 6 -Methyladenosine mRNA Modification and cGAS-STING Pathway Activity in Kidney Fibrosis.

Journal of the American Society of Nephrology : JASN. 2024 Oct 1;35(10):1312-1329 Epub 2024 Jun 10;

Authors: Tsai YC, Hsieh TH, Liao YR, Tsai MT, Lin TP, Lee DY, Park J, Kim D, Susztak K, Yang SF, Lin CC, Li SY

Fibrosis uncovered: ADAMTS12 cuts to the core of extracellular matrix drama.

The Journal of clinical investigation. 2024 Sep 17;134(18);

Authors: Dumoulin B, Susztak K

Transcriptome- and proteome-wide association studies identify genes associated with renal cell carcinoma.

American journal of human genetics. 2024 Sep 5;111(9):1864-1876 Epub 2024 Aug 12;

Authors: Dutta D, Guo X, Winter TD, Jahagirdar O, Renal Cancer Genetics Consortium, Ha E, Susztak K, Machiela MJ, Chanock SJ, Purdue MP

The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Kidney international. 2024 Sep;106(3):369-391 Epub 2024 Jun 4;

Authors: Vivarelli M, Barratt J, Beck LH Jr, Fakhouri F, Gale DP, Goicoechea de Jorge E, Mosca M, Noris M, Pickering MC, Susztak K, Thurman JM, Cheung M, King JM, Jadoul M, Winkelmayer WC, Smith RJH, for Conference Participants

Inferring super-resolution tissue architecture by integrating spatial transcriptomics with histology.

Nature biotechnology. 2024 Sep;42(9):1372-1377 Epub 2024 Jan 2;

Authors: Zhang D, Schroeder A, Yan H, Yang H, Hu J, Lee MYY, Cho KS, Susztak K, Xu GX, Feldman MD, Lee EB, Furth EE, Wang L, Li M

Genome-wide association study of hospitalized patients and acute kidney injury.

Kidney international. 2024 Aug;106(2):291-301 Epub 2024 May 24;

Authors: Siew ED, Hellwege JN, Hung AM, Birkelo BC, Vincz AJ, Parr SK, Denton J, Greevy RA, Robinson-Cohen C, Liu H, Susztak K, Matheny ME, Velez Edwards DR

Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression.

Nature genetics. 2024 Aug;56(8):1712-1724 Epub 2024 Jul 24;

Authors: Abedini A, Levinsohn J, Klötzer KA, Dumoulin B, Ma Z, Frederick J, Dhillon P, Balzer MS, Shrestha R, Liu H, Vitale S, Bergeson AM, Devalaraja-Narashimha K, Grandi P, Bhattacharyya T, Hu E, Pullen SS, Boustany-Kari CM, Guarnieri P, Karihaloo A, Traum D, Yan H, Coleman K, Palmer M, Sarov-Blat L, Morton L, Hunter CA, Kaestner KH, Li M, Susztak K

Diabetes mellitus-Progress and opportunities in the evolving epidemic.

Cell. 2024 Jul 25;187(15):3789-3820;

Authors: Abel ED, Gloyn AL, Evans-Molina C, Joseph JJ, Misra S, Pajvani UB, Simcox J, Susztak K, Drucker DJ

Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape.

Nature communications. 2024 Jul 15;15(1):5937;

Authors: Song L, Li Q, Xia L, Sahay AE, Qiu Q, Li Y, Li H, Sasaki K, Susztak K, Wu H, Wan L

The key role of altered tubule cell lipid metabolism in kidney disease development.

Kidney international. 2024 Jul;106(1):24-34 Epub 2024 Apr 16;

Authors: Lee LE, Doke T, Mukhi D, Susztak K

Matrix Metalloproteinase-2 and CKD Progression: The Chronic Renal Insufficiency Cohort (CRIC) Study.

Kidney medicine. 2024 Aug;6(8):100850 Epub 2024 Jun 6;

Authors: Baudier RL, Orlandi PF, Yang W, Chen HY, Bansal N, Blackston JW, Chen J, Deo R, Dobre M, He H, He J, Ricardo AC, Shafi T, Srivastava A, Xie D, Susztak K, Feldman HI, Anderson AH, CRIC Study Investigators

A comparative scRNAseq data analysis to match mouse models with human kidney disease at the molecular level.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2024 May 31;39(6):1044-1047;

Authors: Abdank K, Cetin SZ, Abedini A, Susztak K, Eckardt KU, Balzer MS

Improve-RRBS: a novel tool to correct the 3' trimming of reduced representation sequencing reads.

Bioinformatics advances. 2024;4(1):vbae076 Epub 2024 May 24;

Authors: Fóthi Á, Liu H, Susztak K, Aranyi T

Single-Cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape.

bioRxiv : the preprint server for biology. 2024 May 10;

Authors: Song L, Li Q, Xia L, Sahay A, Qiu Q, Li Y, Li H, Sasaki K, Susztak K, Wu H, Wan L

The 14th International Podocyte Conference 2023: from podocyte biology to glomerular medicine.

Kidney international. 2024 May;105(5):935-952 Epub 2024 Mar 4;

Authors: Koehler S, Hengel FE, Dumoulin B, Damashek L, Holzman LB, Susztak K, Huber TB, International Podocyte Conference Organizing Committee

Immunological Signatures in Blood and Urine in 80 Individuals Hospitalized during the Initial Phase of COVID-19 Pandemic with Quantified Nicotine Exposure.

International journal of molecular sciences. 2024 Mar 27;25(7);

Authors: Laudanski K, Mahmoud MA, Ahmed AS, Susztak K, Mathew A, Chen J

Author Correction: Unraveling the epigenetic code: human kidney DNA methylation and chromatin dynamics in renal disease development.

Nature communications. 2024 Mar 21;15(1):2537;

Authors: Yan Y, Liu H, Abedini A, Sheng X, Palmer M, Li H, Susztak K

Genetic Studies Highlight the Role of TET2 and INO80 in DNA Damage Response and Kidney Disease Pathogenesis.

bioRxiv : the preprint server for biology. 2024 Feb 7;

Authors: Liang X, Liu H, Hu H, Zhou J, Abedini A, Navarro AS, Klötzer KA, Susztak K

Unraveling the epigenetic code: human kidney DNA methylation and chromatin dynamics in renal disease development.

Nature communications. 2024 Jan 29;15(1):873;

Authors: Yan Y, Liu H, Abedini A, Sheng X, Palmer M, Li H, Susztak K

Niche-DE: niche-differential gene expression analysis in spatial transcriptomics data identifies context-dependent cell-cell interactions.

Genome biology. 2024 Jan 12;25(1):14;

Authors: Mason K, Sathe A, Hess PR, Rong J, Wu CY, Furth E, Susztak K, Levinsohn J, Ji HP, Zhang N

Single-cell transcriptomics and chromatin accessibility profiling elucidate the kidney-protective mechanism of mineralocorticoid receptor antagonists.

The Journal of clinical investigation. 2024 Jan 2;134(1);

Authors: Abedini A, Sánchez-Navaro A, Wu J, Klötzer KA, Ma Z, Poudel B, Doke T, Balzer MS, Frederick J, Cernecka H, Liu H, Liang X, Vitale S, Kolkhof P, Susztak K

MRI-based quantification of whole-organ renal metabolic rate of oxygen.

NMR in biomedicine. 2024 Jan;37(1):e5036 Epub 2023 Sep 25;

Authors: Deshpande RS, Langham MC, Susztak K, Wehrli FW

ACSS2 gene variants determine kidney disease risk by controlling de novo lipogenesis in kidney tubules.

The Journal of clinical investigation. 2023 Dec 5;134(4);

Authors: Mukhi D, Li L, Liu H, Doke T, Kolligundla LP, Ha E, Kloetzer K, Abedini A, Mukherjee S, Wu J, Dhillon P, Hu H, Guan D, Funai K, Uehara K, Titchenell PM, Baur JA, Wellen KE, Susztak K

Erratum to "Deletion of protein tyrosine phosphatase SHP-1 restores SUMOylation of podocin and reverses the progression of diabetic kidney disease." Kidney Int. 2023;104:787-802.

Kidney international. 2023 Dec;104(6):1228;

Authors: Lizotte F, Rousseau M, Denhez B, Lévesque D, Guay A, Liu H, Moreau J, Higgins S, Sabbagh R, Susztak K, Boisvert FM, Côté AM, Geraldes P

HIV viral protein R induces loss of DCT1-type renal tubules.

bioRxiv : the preprint server for biology. 2023 Nov 13;

Authors: Latt KZ, Yoshida T, Shrivastav S, Abedini A, Reece JM, Sun Z, Lee H, Okamoto K, Dagur P, Heymann J, Zhao Y, Chung JY, Hewitt S, Jose PA, Lee K, He JC, Winkler CA, Knepper MA, Kino T, Rosenberg AZ, Susztak K, Kopp JB

Unified Mouse and Human Kidney Single-Cell Expression Atlas Reveal Commonalities and Differences in Disease States.

Journal of the American Society of Nephrology : JASN. 2023 Nov 1;34(11):1843-1862 Epub 2023 Aug 28;

Authors: Zhou J, Abedini A, Balzer MS, Shrestha R, Dhillon P, Liu H, Hu H, Susztak K

Genetic Inhibition of APOL1 Pore-Forming Function Prevents APOL1-Mediated Kidney Disease.

Journal of the American Society of Nephrology : JASN. 2023 Nov 1;34(11):1889-1899 Epub 2023 Oct 6;

Authors: Hung AM, Assimon VA, Chen HC, Yu Z, Vlasschaert C, Triozzi JL, Chan H, Wheless L, Wilson O, Shah SC, Mack T, Thompson T, Matheny ME, Chandrasekar S, Mozaffari SV, Chung CP, Tsao P, Susztak K, Siew ED, Estrada K, Gaziano JM, Graham RR, Tao R, Hoek M, Robinson-Cohen C, Green EM, Bick AG, Million Veteran Program

Deep phenotyping of the lipidomic response in COVID-19 and non-COVID-19 sepsis.

Clinical and translational medicine. 2023 Nov;13(11):e1440;

Authors: Meng H, Sengupta A, Ricciotti E, Mrčela A, Mathew D, Mazaleuskaya LL, Ghosh S, Brooks TG, Turner AP, Schanoski AS, Lahens NF, Tan AW, Woolfork A, Grant G, Susztak K, Letizia AG, Sealfon SC, Wherry EJ, Laudanski K, Weljie AM, Meyer NJ, FitzGerald GA

Combing Genome-Wide Association Studies and Single-Cell Analysis to Elucidate the Mechanisms of Kidney Disease: Proceedings of the Henry Shavelle Professorship.

Glomerular diseases. 2023 Jan-Dec;3(1):258-265 Epub 2023 Oct 30;

Authors: Levinsohn J, Li S, Ha E, Susztak K

Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization.

Nature communications. 2023 Oct 17;14(1):6531;

Authors: Onodera T, Wang MY, Rutkowski JM, Deja S, Chen S, Balzer MS, Kim DS, Sun X, An YA, Field BC, Lee C, Matsuo EI, Mizerska M, Sanjana I, Fujiwara N, Kusminski CM, Gordillo R, Gautron L, Marciano DK, Hu MC, Burgess SC, Susztak K, Moe OW, Scherer PE

Deletion of protein tyrosine phosphatase SHP-1 restores SUMOylation of podocin and reverses the progression of diabetic kidney disease.

Kidney international. 2023 Oct;104(4):787-802 Epub 2023 Jul 27;

Authors: Lizotte F, Rousseau M, Denhez B, Lévesque D, Guay A, Liu H, Moreau J, Higgins S, Sabbagh R, Susztak K, Boisvert FM, Côté AM, Geraldes P

Signal recovery in single cell batch integration.

bioRxiv : the preprint server for biology. 2023 Sep 23;

Authors: Zhang Z, Mathew D, Lim T, Mason K, Martinez CM, Huang S, Wherry EJ, Susztak K, Minn AJ, Ma Z, Zhang NR

Unbiased Human Kidney Tissue Proteomics Identifies Matrix Metalloproteinase 7 as a Kidney Disease Biomarker.

Journal of the American Society of Nephrology : JASN. 2023 Jul 1;34(7):1279-1291 Epub 2023 Apr 5;

Authors: Hirohama D, Abedini A, Moon S, Surapaneni A, Dillon ST, Vassalotti A, Liu H, Doke T, Martinez V, Md Dom Z, Karihaloo A, Palmer MB, Coresh J, Grams ME, Niewczas MA, Susztak K

CureGN-Diabetes Study: Rationale, Design, and Methods of a Prospective Observational Study of Glomerular Disease Patients with Diabetes.

Glomerular diseases. 2023 Jan-Dec;3(1):155-164 Epub 2023 Jun 26;

Authors: Mottl AK, Bomback AS, Mariani LH, Coppock G, Jennette JC, Almaani S, Gipson DS, Kelley S, Kidd J, Laurin LP, Mucha K, Oliverio A, Palmer M, Rizk D, Sanghani N, Stokes MB, Susztak K, Wadhwani S, Nast CC

Transcriptome- and proteome-wide association studies nominate determinants of kidney function and damage.

Genome biology. 2023 Jun 26;24(1):150;

Authors: Schlosser P, Zhang J, Liu H, Surapaneni AL, Rhee EP, Arking DE, Yu B, Boerwinkle E, Welling PA, Chatterjee N, Susztak K, Coresh J, Grams ME

Deep Phenotyping of the Lipidomic Response in COVID and non-COVID Sepsis.

bioRxiv : the preprint server for biology. 2023 Jun 2;

Authors: Meng H, Sengupta A, Ricciotti E, Mrčela A, Mathew D, Mazaleuskaya LL, Ghosh S, Brooks TG, Turner AP, Schanoski AS, Lahens NF, Tan AW, Woolfork A, Grant G, Susztak K, Letizia AG, Sealfon SC, Wherry EJ, Laudanski K, Weljie AM, Meyer NB, FitzGerald GA

DNA methylation markers for kidney function and progression of diabetic kidney disease.

Nature communications. 2023 May 15;14(1):2543;

Authors: Li KY, Tam CHT, Liu H, Day S, Lim CKP, So WY, Huang C, Jiang G, Shi M, Lee HM, TRANSCEND Consortium, Lan HY, Szeto CC, Hanson RL, Nelson RG, Susztak K, Chan JCN, Yip KY, Ma RCW

Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation.

Development (Cambridge, England). 2023 May 1;150(9) Epub 2023 May 12;

Authors: Goodwin AT, John AE, Joseph C, Habgood A, Tatler AL, Susztak K, Palmer M, Offermanns S, Henderson NC, Jenkins RG

Unmasking the elusive erythropoietin-producing 'Norn' cell.

Nature medicine. 2023 May;29(5):1064-1065;

Authors: Abedini A, Klötzer KA, Susztak K

Treatment effects of soluble guanylate cyclase modulation on diabetic kidney disease at single-cell resolution.

Cell reports. Medicine. 2023 Apr 18;4(4):100992 Epub 2023 Apr 5;

Authors: Balzer MS, Pavkovic M, Frederick J, Abedini A, Freyberger A, Vienenkötter J, Mathar I, Siudak K, Eitner F, Sandner P, Grundmann M, Susztak K

Tet2- and Tet3- Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment.

Journal of the American Society of Nephrology : JASN. 2023 Apr 1;34(4):572-589 Epub 2022 Dec 15;

Authors: Liang X, Aranyi T, Zhou J, Guan Y, Hu H, Liu H, Susztak K

Worsened Outcome in Patients with Membranous Nephropathy Carrying Apolipoprotein L1 High-Risk Genotype.

Clinical journal of the American Society of Nephrology : CJASN. 2023 Mar 1;18(3):303-305 Epub 2023 Feb 9;

Authors: Susztak K

NAD(+) precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury.

Nature metabolism. 2023 Mar;5(3):414-430 Epub 2023 Mar 13;

Authors: Doke T, Mukherjee S, Mukhi D, Dhillon P, Abedini A, Davis JG, Chellappa K, Chen B, Baur JA, Susztak K

Molecular pathways that drive diabetic kidney disease.

The Journal of clinical investigation. 2023 Feb 15;133(4);

Authors: Mohandes S, Doke T, Hu H, Mukhi D, Dhillon P, Susztak K

Increased levels of endogenous retroviruses trigger fibroinflammation and play a role in kidney disease development.

Nature communications. 2023 Feb 2;14(1):559;

Authors: Dhillon P, Mulholland KA, Hu H, Park J, Sheng X, Abedini A, Liu H, Vassalotti A, Wu J, Susztak K

Multiomics analysis reveals that hepatocyte nuclear factor 1β regulates axon guidance genes in the developing mouse kidney.

Scientific reports. 2022 Oct 20;12(1):17586;

Authors: Shao A, Gearhart MD, Chan SC, Miao Z, Susztak K, Igarashi P

The multifaceted role of kidney tubule mitochondrial dysfunction in kidney disease development.

Trends in cell biology. 2022 Oct;32(10):841-853 Epub 2022 Apr 25;

Authors: Doke T, Susztak K

Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease.

Diabetologia. 2022 Sep;65(9):1495-1509 Epub 2022 Jun 28;

Authors: Sandholm N, Cole JB, Nair V, Sheng X, Liu H, Ahlqvist E, van Zuydam N, Dahlström EH, Fermin D, Smyth LJ, Salem RM, Forsblom C, Valo E, Harjutsalo V, Brennan EP, McKay GJ, Andrews D, Doyle R, Looker HC, Nelson RG, Palmer C, McKnight AJ, Godson C, Maxwell AP, Groop L, McCarthy MI, Kretzler M, Susztak K, Hirschhorn JN, Florez JC, Groop PH, GENIE Consortium

Genetic Variants Associated With Mineral Metabolism Traits in Chronic Kidney Disease.

The Journal of clinical endocrinology and metabolism. 2022 Aug 18;107(9):e3866-e3876;

Authors: Laster ML, Rowan B, Chen HC, Schwantes-An TH, Sheng X, Friedman PA, Ikizler TA, Sinshiemer JS, Ix JH, Susztak K, de Boer IH, Kestenbaum B, Hung A, Moe SM, Perwad F, Robinson-Cohen C

Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration.

Nature communications. 2022 Jul 11;13(1):4018;

Authors: Balzer MS, Doke T, Yang YW, Aldridge DL, Hu H, Mai H, Mukhi D, Ma Z, Shrestha R, Palmer MB, Hunter CA, Susztak K

Antisense oligonucleotides ameliorate kidney dysfunction in podocyte-specific APOL1 risk variant mice.

Molecular therapy : the journal of the American Society of Gene Therapy. 2022 Jul 6;30(7):2491-2504 Epub 2022 Apr 20;

Authors: Yang YW, Poudel B, Frederick J, Dhillon P, Shrestha R, Ma Z, Wu J, Okamoto K, Kopp JB, Booten SL, Gattis D, Watt AT, Palmer M, Aghajan M, Susztak K

Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.

Nature genetics. 2022 Jul;54(7):950-962 Epub 2022 Jun 16;

Authors: Liu H, Doke T, Guo D, Sheng X, Ma Z, Park J, Vy HMT, Nadkarni GN, Abedini A, Miao Z, Palmer M, Voight BF, Li H, Brown CD, Ritchie MD, Shu Y, Susztak K

Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis.

Nature immunology. 2022 Jun;23(6):947-959 Epub 2022 May 12;

Authors: Doke T, Abedini A, Aldridge DL, Yang YW, Park J, Hernandez CM, Balzer MS, Shrestra R, Coppock G, Rico JMI, Han SY, Kim J, Xin S, Piliponsky AM, Angelozzi M, Lefebvre V, Siracusa MC, Hunter CA, Susztak K

APOL1 Kidney Risk Variants and Proteomics.

Clinical journal of the American Society of Nephrology : CJASN. 2022 May;17(5):684-692 Epub 2022 Apr 26;

Authors: Chen TK, Surapaneni AL, Arking DE, Ballantyne CM, Boerwinkle E, Chen J, Coresh J, Köttgen A, Susztak K, Tin A, Yu B, Grams ME

APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program.

JAMA internal medicine. 2022 Apr 1;182(4):386-395;

Authors: Hung AM, Shah SC, Bick AG, Yu Z, Chen HC, Hunt CM, Wendt F, Wilson O, Greevy RA, Chung CP, Suzuki A, Ho YL, Akwo E, Polimanti R, Zhou J, Reaven P, Tsao PS, Gaziano JM, Huffman JE, Joseph J, Luoh SW, Iyengar S, Chang KM, Casas JP, Matheny ME, O'Donnell CJ, Cho K, Tao R, Susztak K, Robinson-Cohen C, Tuteja S, Siew ED, VA Million Veteran Program COVID-19 Science Initiative

Emerging Role of Clinical Genetics in CKD.

Kidney medicine. 2022 Apr;4(4):100435 Epub 2022 Feb 11;

Authors: Devarajan P, Chertow GM, Susztak K, Levin A, Agarwal R, Stenvinkel P, Chapman AB, Warady BA

How Many Cell Types Are in the Kidney and What Do They Do?

Annual review of physiology. 2022 Feb 10;84:507-531 Epub 2021 Nov 29;

Authors: Balzer MS, Rohacs T, Susztak K

From mapping kidney function to mechanism and prediction.

Nature reviews. Nephrology. 2022 Feb;18(2):76-77;

Authors: Hirohama D, Susztak K

NAD(+) flux is maintained in aged mice despite lower tissue concentrations.

Cell systems. 2021 Dec 15;12(12):1160-1172.e4 Epub 2021 Sep 23;

Authors: McReynolds MR, Chellappa K, Chiles E, Jankowski C, Shen Y, Chen L, Descamps HC, Mukherjee S, Bhat YR, Lingala SR, Chu Q, Botolin P, Hayat F, Doke T, Susztak K, Thaiss CA, Lu W, Migaud ME, Su X, Rabinowitz JD, Baur JA

Meta-analyses identify DNA methylation associated with kidney function and damage.

Nature communications. 2021 Dec 9;12(1):7174;

Authors: Schlosser P, Tin A, Matias-Garcia PR, Thio CHL, Joehanes R, Liu H, Weihs A, Yu Z, Hoppmann A, Grundner-Culemann F, Min JL, Adeyemo AA, Agyemang C, Ärnlöv J, Aziz NA, Baccarelli A, Bochud M, Brenner H, Breteler MMB, Carmeli C, Chaker L, Chambers JC, Cole SA, Coresh J, Corre T, Correa A, Cox SR, de Klein N, Delgado GE, Domingo-Relloso A, Eckardt KU, Ekici AB, Endlich K, Evans KL, Floyd JS, Fornage M, Franke L, Fraszczyk E, Gao X, Gào X, Ghanbari M, Ghasemi S, Gieger C, Greenland P, Grove ML, Harris SE, Hemani G, Henneman P, Herder C, Horvath S, Hou L, Hurme MA, Hwang SJ, Jarvelin MR, Kardia SLR, Kasela S, Kleber ME, Koenig W, Kooner JS, Kramer H, Kronenberg F, Kühnel B, Lehtimäki T, Lind L, Liu D, Liu Y, Lloyd-Jones DM, Lohman K, Lorkowski S, Lu AT, Marioni RE, März W, McCartney DL, Meeks KAC, Milani L, Mishra PP, Nauck M, Navas-Acien A, Nowak C, Peters A, Prokisch H, Psaty BM, Raitakari OT, Ratliff SM, Reiner AP, Rosas SE, Schöttker B, Schwartz J, Sedaghat S, Smith JA, Sotoodehnia N, Stocker HR, Stringhini S, Sundström J, Swenson BR, Tellez-Plaza M, van Meurs JBJ, van Vliet-Ostaptchouk JV, Venema A, Verweij N, Walker RM, Wielscher M, Winkelmann J, Wolffenbuttel BHR, Zhao W, Zheng Y, Estonian Biobank Research Team, Genetics of DNA Methylation Consortium, Loh M, Snieder H, Levy D, Waldenberger M, Susztak K, Köttgen A, Teumer A

Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus.

Nature communications. 2021 Dec 9;12(1):7173;

Authors: Tin A, Schlosser P, Matias-Garcia PR, Thio CHL, Joehanes R, Liu H, Yu Z, Weihs A, Hoppmann A, Grundner-Culemann F, Min JL, Kuhns VLH, Adeyemo AA, Agyemang C, Ärnlöv J, Aziz NA, Baccarelli A, Bochud M, Brenner H, Bressler J, Breteler MMB, Carmeli C, Chaker L, Coresh J, Corre T, Correa A, Cox SR, Delgado GE, Eckardt KU, Ekici AB, Endlich K, Floyd JS, Fraszczyk E, Gao X, Gào X, Gelber AC, Ghanbari M, Ghasemi S, Gieger C, Greenland P, Grove ML, Harris SE, Hemani G, Henneman P, Herder C, Horvath S, Hou L, Hurme MA, Hwang SJ, Kardia SLR, Kasela S, Kleber ME, Koenig W, Kooner JS, Kronenberg F, Kühnel B, Ladd-Acosta C, Lehtimäki T, Lind L, Liu D, Lloyd-Jones DM, Lorkowski S, Lu AT, Marioni RE, März W, McCartney DL, Meeks KAC, Milani L, Mishra PP, Nauck M, Nowak C, Peters A, Prokisch H, Psaty BM, Raitakari OT, Ratliff SM, Reiner AP, Schöttker B, Schwartz J, Sedaghat S, Smith JA, Sotoodehnia N, Stocker HR, Stringhini S, Sundström J, Swenson BR, van Meurs JBJ, van Vliet-Ostaptchouk JV, Venema A, Völker U, Winkelmann J, Wolffenbuttel BHR, Zhao W, Zheng Y, Estonian Biobank Research Team, Genetics of DNA Methylation Consortium, Loh M, Snieder H, Waldenberger M, Levy D, Akilesh S, Woodward OM, Susztak K, Teumer A, Köttgen A

Gaining insight into metabolic diseases from human genetic discoveries.

Trends in genetics : TIG. 2021 Dec;37(12):1081-1094 Epub 2021 Jul 24;

Authors: Claussnitzer M, Susztak K

Kidney toxicity of the BRAF-kinase inhibitor vemurafenib is driven by off-target ferrochelatase inhibition.

Kidney international. 2021 Dec;100(6):1214-1226 Epub 2021 Sep 15;

Authors: Bai Y, Kim JY, Bisunke B, Jayne LA, Silvaroli JA, Balzer MS, Gandhi M, Huang KM, Sander V, Prosek J, Cianciolo RE, Baker SD, Sparreboom A, Jhaveri KD, Susztak K, Bajwa A, Pabla NS

Urine Single-Cell RNA Sequencing in Focal Segmental Glomerulosclerosis Reveals Inflammatory Signatures.

Kidney international reports. 2022 Feb;7(2):289-304 Epub 2021 Nov 25;

Authors: Latt KZ, Heymann J, Jessee JH, Rosenberg AZ, Berthier CC, Arazi A, Eddy S, Yoshida T, Zhao Y, Chen V, Nelson GW, Cam M, Kumar P, Mehta M, Kelly MC, Kretzler M, Nephrotic Syndrome Study Network (NEPTUNE), Accelerating Medicines Partnership in Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Ray PE, Moxey-Mims M, Gorman GH, Lechner BL, Regunathan-Shenk R, Raj DS, Susztak K, Winkler CA, Kopp JB

Author Correction: Longitudinal urinary biomarkers of immunological activation in covid-19 patients without clinically apparent kidney disease versus acute and chronic failure.

Scientific reports. 2021 Nov 11;11(1):22456;

Authors: Laudanski K, Okeke T, Hajj J, Siddiq K, Rader DJ, Wu J, Susztak K

APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis.

Immunity. 2021 Nov 9;54(11):2632-2649.e6 Epub 2021 Oct 12;

Authors: Wu J, Ma Z, Raman A, Beckerman P, Dhillon P, Mukhi D, Palmer M, Chen HC, Cohen CR, Dunn T, Reilly J, Meyer N, Shashaty M, Arany Z, Haskó G, Laudanski K, Hung A, Susztak K

Genome-wide association studies identify the role of caspase-9 in kidney disease.

Science advances. 2021 Nov 5;7(45):eabi8051;

Authors: Doke T, Huang S, Qiu C, Sheng X, Seasock M, Liu H, Ma Z, Palmer M, Susztak K

Renal Histologic Analysis Provides Complementary Information to Kidney Function Measurement for Patients with Early Diabetic or Hypertensive Disease.

Journal of the American Society of Nephrology : JASN. 2021 Nov;32(11):2863-2876 Epub 2021 Aug 4;

Authors: Quinn GZ, Abedini A, Liu H, Ma Z, Cucchiara A, Havasi A, Hill J, Palmer MB, Susztak K

The key role of NLRP3 and STING in APOL1-associated podocytopathy.

The Journal of clinical investigation. 2021 Oct 15;131(20);

Authors: Wu J, Raman A, Coffey NJ, Sheng X, Wahba J, Seasock MJ, Ma Z, Beckerman P, Laczkó D, Palmer MB, Kopp JB, Kuo JJ, Pullen SS, Boustany-Kari CM, Linkermann A, Susztak K

Longitudinal urinary biomarkers of immunological activation in covid-19 patients without clinically apparent kidney disease versus acute and chronic failure.

Scientific reports. 2021 Oct 4;11(1):19675;

Authors: Laudanski K, Okeke T, Hajj J, Siddiq K, Rader DJ, Wu J, Susztak K

Association of Coding Variants in Hydroxysteroid 17-beta Dehydrogenase 14 (HSD17B14) with Reduced Progression to End Stage Kidney Disease in Type 1 Diabetes.

Journal of the American Society of Nephrology : JASN. 2021 Oct;32(10):2634-2651 Epub 2021 Jul 14;

Authors: Mychaleckyj JC, Valo E, Ichimura T, Ahluwalia TS, Dina C, Miller RG, Shabalin IG, Gyorgy B, Cao J, Onengut-Gumuscu S, Satake E, Smiles AM, Haukka JK, Tregouet DA, Costacou T, O'Neil K, Paterson AD, Forsblom C, Keenan HA, Pezzolesi MG, Pragnell M, Galecki A, Rich SS, Sandholm N, Klein R, Klein BE, Susztak K, Orchard TJ, Korstanje R, King GL, Hadjadj S, Rossing P, Bonventre JV, Groop PH, Warram JH, Krolewski AS

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments.

Nature genetics. 2021 Sep;53(9):1322-1333 Epub 2021 Aug 12;

Authors: Sheng X, Guan Y, Ma Z, Wu J, Liu H, Qiu C, Vitale S, Miao Z, Seasock MJ, Palmer M, Shin MK, Duffin KL, Pullen SS, Edwards TL, Hellwege JN, Hung AM, Li M, Voight BF, Coffman TM, Brown CD, Susztak K

A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.

Nature communications. 2021 Aug 23;12(1):5078;

Authors: Guan Y, Liang X, Ma Z, Hu H, Liu H, Miao Z, Linkermann A, Hellwege JN, Voight BF, Susztak K

Unbiased Analysis of Temporal Changes in Immune Serum Markers in Acute COVID-19 Infection With Emphasis on Organ Failure, Anti-Viral Treatment, and Demographic Characteristics.

Frontiers in immunology. 2021;12:650465 Epub 2021 Jun 11;

Authors: Laudanski K, Jihane H, Antalosky B, Ghani D, Phan U, Hernandez R, Okeke T, Wu J, Rader D, Susztak K

How to Get Started with Single Cell RNA Sequencing Data Analysis.

Journal of the American Society of Nephrology : JASN. 2021 Jun 1;32(6):1279-1292 Epub 2021 Mar 15;

Authors: Balzer MS, Ma Z, Zhou J, Abedini A, Susztak K

APOL1 at 10 years: progress and next steps.

Kidney international. 2021 Jun;99(6):1296-1302 Epub 2021 Mar 29;

Authors: Freedman BI, Kopp JB, Sampson MG, Susztak K

Transcriptome-wide association analysis identifies DACH1 as a kidney disease risk gene that contributes to fibrosis.

The Journal of clinical investigation. 2021 May 17;131(10);

Authors: Doke T, Huang S, Qiu C, Liu H, Guan Y, Hu H, Ma Z, Wu J, Miao Z, Sheng X, Zhou J, Cao A, Li J, Kaufman L, Hung A, Brown CD, Pestell R, Susztak K

DACH1 protects podocytes from experimental diabetic injury and modulates PTIP-H3K4Me3 activity.

The Journal of clinical investigation. 2021 May 17;131(10);

Authors: Cao A, Li J, Asadi M, Basgen JM, Zhu B, Yi Z, Jiang S, Doke T, El Shamy O, Patel N, Cravedi P, Azeloglu EU, Campbell KN, Menon M, Coca S, Zhang W, Wang H, Zen K, Liu Z, Murphy B, He JC, D'Agati VD, Susztak K, Kaufman L

Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study.

Clinical epigenetics. 2021 May 1;13(1):99;

Authors: Smyth LJ, Kilner J, Nair V, Liu H, Brennan E, Kerr K, Sandholm N, Cole J, Dahlström E, Syreeni A, Salem RM, Nelson RG, Looker HC, Wooster C, Anderson K, McKay GJ, Kee F, Young I, Andrews D, Forsblom C, Hirschhorn JN, Godson C, Groop PH, Maxwell AP, Susztak K, Kretzler M, Florez JC, McKnight AJ

Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets.

Nature communications. 2021 Apr 15;12(1):2277;

Authors: Miao Z, Balzer MS, Ma Z, Liu H, Wu J, Shrestha R, Aranyi T, Kwan A, Kondo A, Pontoglio M, Kim J, Li M, Kaestner KH, Susztak K

Defining the lineage of thermogenic perivascular adipose tissue.

Nature metabolism. 2021 Apr;3(4):469-484 Epub 2021 Apr 12;

Authors: Angueira AR, Sakers AP, Holman CD, Cheng L, Arbocco MN, Shamsi F, Lynes MD, Shrestha R, Okada C, Batmanov K, Susztak K, Tseng YH, Liaw L, Seale P

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis.

The Journal of clinical investigation. 2021 Mar 1;131(5);

Authors: Miguel V, Tituaña J, Herrero JI, Herrero L, Serra D, Cuevas P, Barbas C, Puyol DR, Márquez-Expósito L, Ruiz-Ortega M, Castillo C, Sheng X, Susztak K, Ruiz-Canela M, Salas-Salvadó J, González MAM, Ortega S, Ramos R, Lamas S

Urinary Single-Cell Profiling Captures the Cellular Diversity of the Kidney.

Journal of the American Society of Nephrology : JASN. 2021 Mar;32(3):614-627 Epub 2021 Feb 2;

Authors: Abedini A, Zhu YO, Chatterjee S, Halasz G, Devalaraja-Narashimha K, Shrestha R, S Balzer M, Park J, Zhou T, Ma Z, Sullivan KM, Hu H, Sheng X, Liu H, Wei Y, Boustany-Kari CM, Patel U, Almaani S, Palmer M, Townsend R, Blady S, Hogan J, Morton L, Susztak K, TRIDENT Study Investigators

The Role of Glomerular Epithelial Injury in Kidney Function Decline in Patients With Diabetic Kidney Disease in the TRIDENT Cohort.

Kidney international reports. 2021 Apr;6(4):1066-1080 Epub 2021 Feb 3;

Authors: Palmer MB, Abedini A, Jackson C, Blady S, Chatterjee S, Sullivan KM, Townsend RR, Brodbeck J, Almaani S, Srivastava A, Avasare R, Ross MJ, Mottl AK, Argyropoulos C, Hogan J, Susztak K

The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation.

Cell metabolism. 2021 Feb 2;33(2):379-394.e8 Epub 2020 Dec 9;

Authors: Dhillon P, Park J, Hurtado Del Pozo C, Li L, Doke T, Huang S, Zhao J, Kang HM, Shrestra R, Balzer MS, Chatterjee S, Prado P, Han SY, Liu H, Sheng X, Dierickx P, Batmanov K, Romero JP, Prósper F, Li M, Pei L, Kim J, Montserrat N, Susztak K

Kidney disease genetic risk variants alter lysosomal beta-mannosidase (MANBA) expression and disease severity.

Science translational medicine. 2021 Jan 13;13(576);

Authors: Gu X, Yang H, Sheng X, Ko YA, Qiu C, Park J, Huang S, Kember R, Judy RL, Park J, Damrauer SM, Nadkarni G, Loos RJF, My VTH, Chaudhary K, Bottinger EP, Paranjpe I, Saha A, Brown C, Akilesh S, Hung AM, Palmer M, Baras A, Overton JD, Reid J, Ritchie M, Rader DJ, Susztak K

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1).

Autophagy. 2021 Jan;17(1):1-382 Epub 2021 Feb 8;

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Systematic integrated analysis of genetic and epigenetic variation in diabetic kidney disease.

Proceedings of the National Academy of Sciences of the United States of America. 2020 Nov 17;117(46):29013-29024 Epub 2020 Nov 3;

Authors: Sheng X, Qiu C, Liu H, Gluck C, Hsu JY, He J, Hsu CY, Sha D, Weir MR, Isakova T, Raj D, Rincon-Choles H, Feldman HI, Townsend R, Li H, Susztak K

Can kidney parenchyma metabolites serve as prognostic biomarkers for long-term kidney function after nephrectomy for renal cell carcinoma? A preliminary study.

Clinical kidney journal. 2021 Feb;14(2):656-664 Epub 2020 Nov 4;

Authors: Rosenzweig B, Recabal P, Gluck C, Coleman JA, Susztak K, Hakimi AA, Jaimes EA, Weiss RH

Unravelling the complex genetics of common kidney diseases: from variants to mechanisms.

Nature reviews. Nephrology. 2020 Nov;16(11):628-640 Epub 2020 Jun 8;

Authors: Sullivan KM, Susztak K

The transcriptomic signature of the aging podocyte.

Kidney international. 2020 Nov;98(5):1079-1081;

Authors: Mukhi D, Susztak K

Iterative transfer learning with neural network for clustering and cell type classification in single-cell RNA-seq analysis.

Nature machine intelligence. 2020 Oct;2(10):607-618 Epub 2020 Oct 5;

Authors: Hu J, Li X, Hu G, Lyu Y, Susztak K, Li M

Podocytopathies.

Nature reviews. Disease primers. 2020 Aug 13;6(1):68;

Authors: Kopp JB, Anders HJ, Susztak K, Podestà MA, Remuzzi G, Hildebrandt F, Romagnani P

Loss of IL-27Rα Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses.

Journal of immunology (Baltimore, Md. : 1950). 2020 Jul 15;205(2):377-386 Epub 2020 Jun 10;

Authors: Coppock GM, Aronson LR, Park J, Qiu C, Park J, DeLong JH, Radaelli E, Suszták K, Hunter CA

The Feasibility and Safety of Obtaining Research Kidney Biopsy Cores in Patients with Diabetes: An Interim Analysis of the TRIDENT Study.

Clinical journal of the American Society of Nephrology : CJASN. 2020 Jul 1;15(7):1024-1026 Epub 2020 Apr 27;

Authors: Hogan JJ, Owen JG, Blady SJ, Almaani S, Avasare RS, Bansal S, Lenz O, Luciano RL, Parikh SV, Ross MJ, Sharma D, Szerlip H, Wadhwani S, Townsend RR, Palmer MB, Susztak K, Mottl AK, TRIDENT Study Investigators

Complexities of Understanding Function from CKD-Associated DNA Variants.

Clinical journal of the American Society of Nephrology : CJASN. 2020 Jul 1;15(7):1028-1040 Epub 2020 Jun 8;

Authors: Lin J, Susztak K

Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis.

Nature genetics. 2020 Jul;52(7):680-691 Epub 2020 Jun 15;

Authors: Vujkovic M, Keaton JM, Lynch JA, Miller DR, Zhou J, Tcheandjieu C, Huffman JE, Assimes TL, Lorenz K, Zhu X, Hilliard AT, Judy RL, Huang J, Lee KM, Klarin D, Pyarajan S, Danesh J, Melander O, Rasheed A, Mallick NH, Hameed S, Qureshi IH, Afzal MN, Malik U, Jalal A, Abbas S, Sheng X, Gao L, Kaestner KH, Susztak K, Sun YV, DuVall SL, Cho K, Lee JS, Gaziano JM, Phillips LS, Meigs JB, Reaven PD, Wilson PW, Edwards TL, Rader DJ, Damrauer SM, O'Donnell CJ, Tsao PS, HPAP Consortium, Regeneron Genetics Center, VA Million Veteran Program, Chang KM, Voight BF, Saleheen D

The interdependence of renal epithelial and endothelial metabolism and cell state.

Science signaling. 2020 Jun 9;13(635);

Authors: Balzer MS, Susztak K

ASEP: Gene-based detection of allele-specific expression across individuals in a population by RNA sequencing.

PLoS genetics. 2020 May;16(5):e1008786 Epub 2020 May 11;

Authors: Fan J, Hu J, Xue C, Zhang H, Susztak K, Reilly MP, Xiao R, Li M

Deep learning enables accurate clustering with batch effect removal in single-cell RNA-seq analysis.

Nature communications. 2020 May 11;11(1):2338;

Authors: Li X, Wang K, Lyu Y, Pan H, Zhang J, Stambolian D, Susztak K, Reilly MP, Hu G, Li M

Phenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney-specific pathways.

Kidney international. 2020 May;97(5):1032-1041 Epub 2020 Feb 17;

Authors: Bajaj A, Ihegword A, Qiu C, Small AM, Wei WQ, Bastarache L, Feng Q, Kember RL, Risman M, Bloom RD, Birtwell DL, Williams H, Shaffer CM, Chen J, Center RG, Denny JC, Rader DJ, Stein CM, Damrauer SM, Susztak K

A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury.

Nature communications. 2020 Apr 21;11(1):1924;

Authors: Kim JY, Bai Y, Jayne LA, Hector RD, Persaud AK, Ong SS, Rojesh S, Raj R, Feng MJHH, Chung S, Cianciolo RE, Christman JW, Campbell MJ, Gardner DS, Baker SD, Sparreboom A, Govindarajan R, Singh H, Chen T, Poi M, Susztak K, Cobb SR, Pabla NS

Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment.

eLife. 2020 Apr 14;9;

Authors: Zhong L, Yao L, Tower RJ, Wei Y, Miao Z, Park J, Shrestha R, Wang L, Yu W, Holdreith N, Huang X, Zhang Y, Tong W, Gong Y, Ahn J, Susztak K, Dyment N, Li M, Long F, Chen C, Seale P, Qin L

Dnmt3a and Dnmt3b-Decommissioned Fetal Enhancers are Linked to Kidney Disease.

Journal of the American Society of Nephrology : JASN. 2020 Apr;31(4):765-782 Epub 2020 Mar 3;

Authors: Guan Y, Liu H, Ma Z, Li SY, Park J, Sheng X, Susztak K

Inhibition of Endothelial PHD2 Suppresses Post-Ischemic Kidney Inflammation through Hypoxia-Inducible Factor-1.

Journal of the American Society of Nephrology : JASN. 2020 Mar;31(3):501-516 Epub 2020 Jan 29;

Authors: Rajendran G, Schonfeld MP, Tiwari R, Huang S, Torosyan R, Fields T, Park J, Susztak K, Kapitsinou PP

It Takes Two to Tango: The Role of Dysregulated Metabolism and Inflammation in Kidney Disease Development.

Seminars in nephrology. 2020 Mar;40(2):199-205;

Authors: Quinn GZ, Dhillon P, Susztak K

Loss of ELK1 has differential effects on age-dependent organ fibrosis.

The international journal of biochemistry & cell biology. 2020 Mar;120:105668 Epub 2019 Dec 23;

Authors: Cairns JT, Habgood A, Edwards-Pritchard RC, Joseph C, John AE, Wilkinson C, Stewart ID, Leslie J, Blaxall BC, Susztak K, Alberti S, Nordheim A, Oakley F, Jenkins G, Tatler AL

Rationale and design of the Transformative Research in Diabetic Nephropathy (TRIDENT) Study.

Kidney international. 2020 Jan;97(1):10-13;

Authors: Townsend RR, Guarnieri P, Argyropoulos C, Blady S, Boustany-Kari CM, Devalaraja-Narashimha K, Morton L, Mottl AK, Patel U, Palmer M, Ross MJ, Sarov-Blat L, Steinbugler K, Susztak K, TRIDENT Study Investigators

Effective reconstruction of functional organotypic kidney spheroid for in vitro nephrotoxicity studies.

Scientific reports. 2019 Nov 26;9(1):17610;

Authors: Kang HM, Lim JH, Noh KH, Park D, Cho HS, Susztak K, Jung CR

Author Correction: FHL2 mediates podocyte Rac1 activation and foot process effacement in hypertensive nephropathy.

Scientific reports. 2019 Oct 24;9(1):15552;

Authors: Li SY, Chu PH, Huang PH, Hsieh TH, Susztak K, Tarng DC

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.

Cell metabolism. 2019 Oct 1;30(4):784-799.e5 Epub 2019 Aug 29;

Authors: Chung KW, Dhillon P, Huang S, Sheng X, Shrestha R, Qiu C, Kaufman BA, Park J, Pei L, Baur J, Palmer M, Susztak K

Understanding the kidney one cell at a time.

Kidney international. 2019 Oct;96(4):862-870 Epub 2019 Jul 26;

Authors: Park J, Liu CL, Kim J, Susztak K

Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen.

Journal of the American Society of Nephrology : JASN. 2019 Oct;30(10):2000-2016 Epub 2019 Sep 19;

Authors: Salem RM, Todd JN, Sandholm N, Cole JB, Chen WM, Andrews D, Pezzolesi MG, McKeigue PM, Hiraki LT, Qiu C, Nair V, Di Liao C, Cao JJ, Valo E, Onengut-Gumuscu S, Smiles AM, McGurnaghan SJ, Haukka JK, Harjutsalo V, Brennan EP, van Zuydam N, Ahlqvist E, Doyle R, Ahluwalia TS, Lajer M, Hughes MF, Park J, Skupien J, Spiliopoulou A, Liu A, Menon R, Boustany-Kari CM, Kang HM, Nelson RG, Klein R, Klein BE, Lee KE, Gao X, Mauer M, Maestroni S, Caramori ML, de Boer IH, Miller RG, Guo J, Boright AP, Tregouet D, Gyorgy B, Snell-Bergeon JK, Maahs DM, Bull SB, Canty AJ, Palmer CNA, Stechemesser L, Paulweber B, Weitgasser R, Sokolovska J, Rovīte V, Pīrāgs V, Prakapiene E, Radzeviciene L, Verkauskiene R, Panduru NM, Groop LC, McCarthy MI, Gu HF, Möllsten A, Falhammar H, Brismar K, Martin F, Rossing P, Costacou T, Zerbini G, Marre M, Hadjadj S, McKnight AJ, Forsblom C, McKay G, Godson C, Maxwell AP, Kretzler M, Susztak K, Colhoun HM, Krolewski A, Paterson AD, Groop PH, Rich SS, Hirschhorn JN, Florez JC, SUMMIT Consortium, DCCT/EDIC Research Group, GENIE Consortium

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.

Nature genetics. 2019 Oct;51(10):1459-1474 Epub 2019 Oct 2;

Authors: Tin A, Marten J, Halperin Kuhns VL, Li Y, Wuttke M, Kirsten H, Sieber KB, Qiu C, Gorski M, Yu Z, Giri A, Sveinbjornsson G, Li M, Chu AY, Hoppmann A, O'Connor LJ, Prins B, Nutile T, Noce D, Akiyama M, Cocca M, Ghasemi S, van der Most PJ, Horn K, Xu Y, Fuchsberger C, Sedaghat S, Afaq S, Amin N, Ärnlöv J, Bakker SJL, Bansal N, Baptista D, Bergmann S, Biggs ML, Biino G, Boerwinkle E, Bottinger EP, Boutin TS, Brumat M, Burkhardt R, Campana E, Campbell A, Campbell H, Carroll RJ, Catamo E, Chambers JC, Ciullo M, Concas MP, Coresh J, Corre T, Cusi D, Felicita SC, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Delgado G, Demirkan A, Devuyst O, Dittrich K, Eckardt KU, Ehret G, Endlich K, Evans MK, Gansevoort RT, Gasparini P, Giedraitis V, Gieger C, Girotto G, Gögele M, Gordon SD, Gudbjartsson DF, Gudnason V, German Chronic Kidney Disease Study, Haller T, Hamet P, Harris TB, Hayward C, Hicks AA, Hofer E, Holm H, Huang W, Hutri-Kähönen N, Hwang SJ, Ikram MA, Lewis RM, Ingelsson E, Jakobsdottir J, Jonsdottir I, Jonsson H, Joshi PK, Josyula NS, Jung B, Kähönen M, Kamatani Y, Kanai M, Kerr SM, Kiess W, Kleber ME, Koenig W, Kooner JS, Körner A, Kovacs P, Krämer BK, Kronenberg F, Kubo M, Kühnel B, La Bianca M, Lange LA, Lehne B, Lehtimäki T, Lifelines Cohort Study, Liu J, Loeffler M, Loos RJF, Lyytikäinen LP, Magi R, Mahajan A, Martin NG, März W, Mascalzoni D, Matsuda K, Meisinger C, Meitinger T, Metspalu A, Milaneschi Y, V. A. Million Veteran Program, O'Donnell CJ, Wilson OD, Gaziano JM, Mishra PP, Mohlke KL, Mononen N, Montgomery GW, Mook-Kanamori DO, Müller-Nurasyid M, Nadkarni GN, Nalls MA, Nauck M, Nikus K, Ning B, Nolte IM, Noordam R, O'Connell JR, Olafsson I, Padmanabhan S, Penninx BWJH, Perls T, Peters A, Pirastu M, Pirastu N, Pistis G, Polasek O, Ponte B, Porteous DJ, Poulain T, Preuss MH, Rabelink TJ, Raffield LM, Raitakari OT, Rettig R, Rheinberger M, Rice KM, Rizzi F, Robino A, Rudan I, Krajcoviechova A, Cifkova R, Rueedi R, Ruggiero D, Ryan KA, Saba Y, Salvi E, Schmidt H, Schmidt R, Shaffer CM, Smith AV, Smith BH, Spracklen CN, Strauch K, Stumvoll M, Sulem P, Tajuddin SM, Teren A, Thiery J, Thio CHL, Thorsteinsdottir U, Toniolo D, Tönjes A, Tremblay J, Uitterlinden AG, Vaccargiu S, van der Harst P, van Duijn CM, Verweij N, Völker U, Vollenweider P, Waeber G, Waldenberger M, Whitfield JB, Wild SH, Wilson JF, Yang Q, Zhang W, Zonderman AB, Bochud M, Wilson JG, Pendergrass SA, Ho K, Parsa A, Pramstaller PP, Psaty BM, Böger CA, Snieder H, Butterworth AS, Okada Y, Edwards TL, Stefansson K, Susztak K, Scholz M, Heid IM, Hung AM, Teumer A, Pattaro C, Woodward OM, Vitart V, Köttgen A

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.

Nature communications. 2019 Sep 11;10(1):4130;

Authors: Teumer A, Li Y, Ghasemi S, Prins BP, Wuttke M, Hermle T, Giri A, Sieber KB, Qiu C, Kirsten H, Tin A, Chu AY, Bansal N, Feitosa MF, Wang L, Chai JF, Cocca M, Fuchsberger C, Gorski M, Hoppmann A, Horn K, Li M, Marten J, Noce D, Nutile T, Sedaghat S, Sveinbjornsson G, Tayo BO, van der Most PJ, Xu Y, Yu Z, Gerstner L, Ärnlöv J, Bakker SJL, Baptista D, Biggs ML, Boerwinkle E, Brenner H, Burkhardt R, Carroll RJ, Chee ML, Chee ML, Chen M, Cheng CY, Cook JP, Coresh J, Corre T, Danesh J, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Degenhardt F, Dittrich K, Divers J, Eckardt KU, Ehret G, Endlich K, Felix JF, Franco OH, Franke A, Freedman BI, Freitag-Wolf S, Gansevoort RT, Giedraitis V, Gögele M, Grundner-Culemann F, Gudbjartsson DF, Gudnason V, Hamet P, Harris TB, Hicks AA, Holm H, Foo VHX, Hwang SJ, Ikram MA, Ingelsson E, Jaddoe VWV, Jakobsdottir J, Josyula NS, Jung B, Kähönen M, Khor CC, Kiess W, Koenig W, Körner A, Kovacs P, Kramer H, Krämer BK, Kronenberg F, Lange LA, Langefeld CD, Lee JJ, Lehtimäki T, Lieb W, Lim SC, Lind L, Lindgren CM, Liu J, Loeffler M, Lyytikäinen LP, Mahajan A, Maranville JC, Mascalzoni D, McMullen B, Meisinger C, Meitinger T, Miliku K, Mook-Kanamori DO, Müller-Nurasyid M, Mychaleckyj JC, Nauck M, Nikus K, Ning B, Noordam R, Connell JO, Olafsson I, Palmer ND, Peters A, Podgornaia AI, Ponte B, Poulain T, Pramstaller PP, Rabelink TJ, Raffield LM, Reilly DF, Rettig R, Rheinberger M, Rice KM, Rivadeneira F, Runz H, Ryan KA, Sabanayagam C, Saum KU, Schöttker B, Shaffer CM, Shi Y, Smith AV, Strauch K, Stumvoll M, Sun BB, Szymczak S, Tai ES, Tan NYQ, Taylor KD, Teren A, Tham YC, Thiery J, Thio CHL, Thomsen H, Thorsteinsdottir U, Tönjes A, Tremblay J, Uitterlinden AG, van der Harst P, Verweij N, Vogelezang S, Völker U, Waldenberger M, Wang C, Wilson OD, Wong C, Wong TY, Yang Q, Yasuda M, Akilesh S, Bochud M, Böger CA, Devuyst O, Edwards TL, Ho K, Morris AP, Parsa A, Pendergrass SA, Psaty BM, Rotter JI, Stefansson K, Wilson JG, Susztak K, Snieder H, Heid IM, Scholz M, Butterworth AS, Hung AM, Pattaro C, Köttgen A

Cytosine Methylation Studies in Patients with Diabetic Kidney Disease.

Current diabetes reports. 2019 Aug 30;19(10):91;

Authors: Aranyi T, Susztak K

Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program.

Nature communications. 2019 Aug 26;10(1):3842;

Authors: Hellwege JN, Velez Edwards DR, Giri A, Qiu C, Park J, Torstenson ES, Keaton JM, Wilson OD, Robinson-Cohen C, Chung CP, Roumie CL, Klarin D, Damrauer SM, DuVall SL, Siew E, Akwo EA, Wuttke M, Gorski M, Li M, Li Y, Gaziano JM, Wilson PWF, Tsao PS, O'Donnell CJ, Kovesdy CP, Pattaro C, Köttgen A, Susztak K, Edwards TL, Hung AM

Functional methylome analysis of human diabetic kidney disease.

JCI insight. 2019 Jun 6;4(11);

Authors: Park J, Guan Y, Sheng X, Gluck C, Seasock MJ, Hakimi AA, Qiu C, Pullman J, Verma A, Li H, Palmer M, Susztak K

Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease.

Nature communications. 2019 Jun 5;10(1):2461;

Authors: Gluck C, Qiu C, Han SY, Palmer M, Park J, Ko YA, Guan Y, Sheng X, Hanson RL, Huang J, Chen Y, Park ASD, Izquierdo MC, Mantzaris I, Verma A, Pullman J, Li H, Susztak K

Genomic Mismatch at LIMS1 Locus and Kidney Allograft Rejection.

The New England journal of medicine. 2019 May 16;380(20):1918-1928;

Authors: Steers NJ, Li Y, Drace Z, D'Addario JA, Fischman C, Liu L, Xu K, Na YJ, Neugut YD, Zhang JY, Sterken R, Balderes O, Bradbury D, Ozturk N, Ozay F, Goswami S, Mehl K, Wold J, Jelloul FZ, Rohanizadegan M, Gillies CE, Vasilescu EM, Vlad G, Ko YA, Mohan S, Radhakrishnan J, Cohen DJ, Ratner LE, Scolari F, Susztak K, Sampson MG, Deaglio S, Caliskan Y, Barasch J, Courtney AE, Maxwell AP, McKnight AJ, Ionita-Laza I, Bakker SJL, Snieder H, de Borst MH, D'Agati V, Amoroso A, Gharavi AG, Kiryluk K

Going from acute to chronic kidney injury with FoxO3.

The Journal of clinical investigation. 2019 May 6;129(6):2192-2194;

Authors: Gu X, Raman A, Susztak K

The kidney transcriptome, from single cells to whole organs and back.

Current opinion in nephrology and hypertension. 2019 May;28(3):219-226;

Authors: Huang S, Sheng X, Susztak K

A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.

Nature medicine. 2019 May;25(5):805-813 Epub 2019 Apr 22;

Authors: Niewczas MA, Pavkov ME, Skupien J, Smiles A, Md Dom ZI, Wilson JM, Park J, Nair V, Schlafly A, Saulnier PJ, Satake E, Simeone CA, Shah H, Qiu C, Looker HC, Fiorina P, Ware CF, Sun JK, Doria A, Kretzler M, Susztak K, Duffin KL, Nelson RG, Krolewski AS

FHL2 mediates podocyte Rac1 activation and foot process effacement in hypertensive nephropathy.

Scientific reports. 2019 Apr 30;9(1):6693;

Authors: Li SY, Chu PH, Huang PH, Hsieh TH, Susztak K, Tarng DC

DNMT1 in Six2 Progenitor Cells Is Essential for Transposable Element Silencing and Kidney Development.

Journal of the American Society of Nephrology : JASN. 2019 Apr;30(4):594-609 Epub 2019 Mar 8;

Authors: Li SY, Park J, Guan Y, Chung K, Shrestha R, Palmer MB, Susztak K

Ascorbic acid-induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma.

The Journal of clinical investigation. 2019 Mar 4;129(4):1612-1625;

Authors: Shenoy N, Bhagat TD, Cheville J, Lohse C, Bhattacharyya S, Tischer A, Machha V, Gordon-Mitchell S, Choudhary G, Wong LF, Gross L, Ressigue E, Leibovich B, Boorjian SA, Steidl U, Wu X, Pradhan K, Gartrell B, Agarwal B, Pagliaro L, Suzuki M, Greally JM, Rakheja D, Thompson RH, Susztak K, Witzig T, Zou Y, Verma A

Long-Range Chromatin Interactions in the Kidney.

Journal of the American Society of Nephrology : JASN. 2019 Mar;30(3):367-369 Epub 2019 Feb 13;

Authors: Guan Y, Liu H, Susztak K

Bulk tissue cell type deconvolution with multi-subject single-cell expression reference.

Nature communications. 2019 Jan 22;10(1):380;

Authors: Wang X, Park J, Susztak K, Zhang NR, Li M

Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting.

PLoS genetics. 2019 Jan;15(1):e1007874 Epub 2019 Jan 9;

Authors: Symmons O, Chang M, Mellis IA, Kalish JM, Park J, Suszták K, Bartolomei MS, Raj A

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

Nature genetics. 2019 Jan;51(1):51-62 Epub 2018 Dec 21;

Authors: Giri A, Hellwege JN, Keaton JM, Park J, Qiu C, Warren HR, Torstenson ES, Kovesdy CP, Sun YV, Wilson OD, Robinson-Cohen C, Roumie CL, Chung CP, Birdwell KA, Damrauer SM, DuVall SL, Klarin D, Cho K, Wang Y, Evangelou E, Cabrera CP, Wain LV, Shrestha R, Mautz BS, Akwo EA, Sargurupremraj M, Debette S, Boehnke M, Scott LJ, Luan J, Zhao JH, Willems SM, Thériault S, Shah N, Oldmeadow C, Almgren P, Li-Gao R, Verweij N, Boutin TS, Mangino M, Ntalla I, Feofanova E, Surendran P, Cook JP, Karthikeyan S, Lahrouchi N, Liu C, Sepúlveda N, Richardson TG, Kraja A, Amouyel P, Farrall M, Poulter NR, Understanding Society Scientific Group, International Consortium for Blood Pressure, Blood Pressure-International Consortium of Exome Chip Studies, Laakso M, Zeggini E, Sever P, Scott RA, Langenberg C, Wareham NJ, Conen D, Palmer CNA, Attia J, Chasman DI, Ridker PM, Melander O, Mook-Kanamori DO, Harst PV, Cucca F, Schlessinger D, Hayward C, Spector TD, Jarvelin MR, Hennig BJ, Timpson NJ, Wei WQ, Smith JC, Xu Y, Matheny ME, Siew EE, Lindgren C, Herzig KH, Dedoussis G, Denny JC, Psaty BM, Howson JMM, Munroe PB, Newton-Cheh C, Caulfield MJ, Elliott P, Gaziano JM, Concato J, Wilson PWF, Tsao PS, Velez Edwards DR, Susztak K, Million Veteran Program, O'Donnell CJ, Hung AM, Edwards TL

Renal compartment-specific genetic variation analyses identify new pathways in chronic kidney disease.

Nature medicine. 2018 Nov;24(11):1721-1731 Epub 2018 Oct 1;

Authors: Qiu C, Huang S, Park J, Park Y, Ko YA, Seasock MJ, Bryer JS, Xu XX, Song WC, Palmer M, Hill J, Guarnieri P, Hawkins J, Boustany-Kari CM, Pullen SS, Brown CD, Susztak K

Epigenetics and Epigenomics: Implications for Diabetes and Obesity.

Diabetes. 2018 Oct;67(10):1923-1931;

Authors: Rosen ED, Kaestner KH, Natarajan R, Patti ME, Sallari R, Sander M, Susztak K

Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming.

PLoS biology. 2018 Sep;16(9):e2005233 Epub 2018 Sep 18;

Authors: Huang S, Park J, Qiu C, Chung KW, Li SY, Sirin Y, Han SH, Taylor V, Zimber-Strobl U, Susztak K

Associations of Fenofibrate Therapy With Incidence and Progression of CKD in Patients With Type 2 Diabetes.

Kidney international reports. 2019 Jan;4(1):94-102 Epub 2018 Sep 18;

Authors: Frazier R, Mehta R, Cai X, Lee J, Napoli S, Craven T, Tuazon J, Safdi A, Scialla J, Susztak K, Isakova T

APOL1: The Balance Imposed by Infection, Selection, and Kidney Disease.

Trends in molecular medicine. 2018 Aug;24(8):682-695 Epub 2018 Jun 7;

Authors: Beckerman P, Susztak K

Cytosine methylation predicts renal function decline in American Indians.

Kidney international. 2018 Jun;93(6):1417-1431 Epub 2018 Apr 27;

Authors: Qiu C, Hanson RL, Fufaa G, Kobes S, Gluck C, Huang J, Chen Y, Raj D, Nelson RG, Knowler WC, Susztak K

Genomic integration of ERRγ-HNF1β regulates renal bioenergetics and prevents chronic kidney disease.

Proceedings of the National Academy of Sciences of the United States of America. 2018 May 22;115(21):E4910-E4919 Epub 2018 May 7;

Authors: Zhao J, Lupino K, Wilkins BJ, Qiu C, Liu J, Omura Y, Allred AL, McDonald C, Susztak K, Barish GD, Pei L

Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease.

Science (New York, N.Y.). 2018 May 18;360(6390):758-763 Epub 2018 Apr 5;

Authors: Park J, Shrestha R, Qiu C, Kondo A, Huang S, Werth M, Li M, Barasch J, Suszták K

The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α) in Kidney Disease.

Seminars in nephrology. 2018 Mar;38(2):121-126;

Authors: Li SY, Susztak K

Introduction: Systems Biology of Kidney Disease.

Seminars in nephrology. 2018 Mar;38(2):99-100;

Authors: Sharma K, Susztak K, Pennathur S

Screening Drugs for Kidney Disease: Targeting the Podocyte.

Cell chemical biology. 2018 Feb 15;25(2):126-127;

Authors: Bryer JS, Susztak K

Epigenome-wide association studies identify DNA methylation associated with kidney function.

Nature communications. 2017 Nov 3;8(1):1286;

Authors: Chu AY, Tin A, Schlosser P, Ko YA, Qiu C, Yao C, Joehanes R, Grams ME, Liang L, Gluck CA, Liu C, Coresh J, Hwang SJ, Levy D, Boerwinkle E, Pankow JS, Yang Q, Fornage M, Fox CS, Susztak K, Köttgen A

PGC-1α Protects from Notch-Induced Kidney Fibrosis Development.

Journal of the American Society of Nephrology : JASN. 2017 Nov;28(11):3312-3322 Epub 2017 Jul 27;

Authors: Han SH, Wu MY, Nam BY, Park JT, Yoo TH, Kang SW, Park J, Chinga F, Li SY, Susztak K

Human Kidney Tubule-Specific Gene Expression Based Dissection of Chronic Kidney Disease Traits.

EBioMedicine. 2017 Oct;24:267-276 Epub 2017 Sep 18;

Authors: Beckerman P, Qiu C, Park J, Ledo N, Ko YA, Park AD, Han SY, Choi P, Palmer M, Susztak K

APOL1 and Cardiovascular Disease: A Story in Evolution.

Arteriosclerosis, thrombosis, and vascular biology. 2017 Sep;37(9):1587-1589;

Authors: Bajaj A, Susztak K, Damrauer SM

In Utero Exposure to a High-Fat Diet Programs Hepatic Hypermethylation and Gene Dysregulation and Development of Metabolic Syndrome in Male Mice.

Endocrinology. 2017 Sep 1;158(9):2860-2872;

Authors: Seki Y, Suzuki M, Guo X, Glenn AS, Vuguin PM, Fiallo A, Du Q, Ko YA, Yu Y, Susztak K, Zheng D, Greally JM, Katz EB, Charron MJ

Increasing the level of peroxisome proliferator-activated receptor γ coactivator-1α in podocytes results in collapsing glomerulopathy.

JCI insight. 2017 Jul 20;2(14);

Authors: Li SY, Park J, Qiu C, Han SH, Palmer MB, Arany Z, Susztak K

Benign and tumor parenchyma metabolomic profiles affect compensatory renal growth in renal cell carcinoma surgical patients.

PloS one. 2017;12(7):e0180350 Epub 2017 Jul 20;

Authors: Rosenzweig B, Rubinstein ND, Reznik E, Shingarev R, Juluru K, Akin O, Hsieh JJ, Jaimes EA, Russo P, Susztak K, Coleman JA, Hakimi AA

Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids.

Journal of lipid research. 2017 Jun;58(6):1132-1142 Epub 2017 Apr 12;

Authors: Scerbo D, Son NH, Sirwi A, Zeng L, Sas KM, Cifarelli V, Schoiswohl G, Huggins LA, Gumaste N, Hu Y, Pennathur S, Abumrad NA, Kershaw EE, Hussain MM, Susztak K, Goldberg IJ

Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease.

American journal of human genetics. 2017 Jun 1;100(6):940-953;

Authors: Ko YA, Yi H, Qiu C, Huang S, Park J, Ledo N, Köttgen A, Li H, Rader DJ, Pack MA, Brown CD, Susztak K

Precision Medicine Approaches to Diabetic Kidney Disease: Tissue as an Issue.

Current diabetes reports. 2017 May;17(5):30;

Authors: Gluck C, Ko YA, Susztak K

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice.

Nature medicine. 2017 Apr;23(4):429-438 Epub 2017 Feb 20;

Authors: Beckerman P, Bi-Karchin J, Park AS, Qiu C, Dummer PD, Soomro I, Boustany-Kari CM, Pullen SS, Miner JH, Hu CA, Rohacs T, Inoue K, Ishibe S, Saleem MA, Palmer MB, Cuervo AM, Kopp JB, Susztak K

Genome-Wide Association of Copy Number Polymorphisms and Kidney Function.

PloS one. 2017;12(1):e0170815 Epub 2017 Jan 30;

Authors: Li M, Carey J, Cristiano S, Susztak K, Coresh J, Boerwinkle E, Kao WH, Beaty TH, Köttgen A, Scharpf RB

Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal Cancer.

The Journal of biological chemistry. 2017 Jan 20;292(3):837-846 Epub 2016 Dec 1;

Authors: Bhagat TD, Zou Y, Huang S, Park J, Palmer MB, Hu C, Li W, Shenoy N, Giricz O, Choudhary G, Yu Y, Ko YA, Izquierdo MC, Park AS, Vallumsetla N, Laurence R, Lopez R, Suzuki M, Pullman J, Kaner J, Gartrell B, Hakimi AA, Greally JM, Patel B, Benhadji K, Pradhan K, Verma A, Susztak K

Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1.

The Journal of biological chemistry. 2017 Jan 13;292(2):732-747 Epub 2016 Dec 2;

Authors: Lee HW, Khan SQ, Khaliqdina S, Altintas MM, Grahammer F, Zhao JL, Koh KH, Tardi NJ, Faridi MH, Geraghty T, Cimbaluk DJ, Susztak K, Moita LF, Baltimore D, Tharaux PL, Huber TB, Kretzler M, Bitzer M, Reiser J, Gupta V

Therapeutics for APOL1 nephropathies: putting out the fire in the podocyte.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2017 Jan 1;32(suppl_1):i65-i70;

Authors: Heymann J, Winkler CA, Hoek M, Susztak K, Kopp JB

A High Fat Diet During Pregnancy and Lactation Induces Cardiac and Renal Abnormalities in GLUT4 +/- Male Mice.

Kidney & blood pressure research. 2017;42(3):468-482 Epub 2017 Jul 27;

Authors: Kruse M, Fiallo A, Tao J, Susztak K, Amann K, Katz EB, Charron MJ

Partitioning-Defective 1a/b Depletion Impairs Glomerular and Proximal Tubule Development.

Journal of the American Society of Nephrology : JASN. 2016 Dec;27(12):3725-3737 Epub 2016 May 16;

Authors: Akchurin O, Du Z, Ramkellawan N, Dalal V, Han SH, Pullman J, Müsch A, Susztak K, Reidy KJ

The long noncoding RNA Tug1 connects metabolic changes with kidney disease in podocytes.

The Journal of clinical investigation. 2016 Nov 1;126(11):4072-4075 Epub 2016 Oct 17;

Authors: Li SY, Susztak K

Developing Treatments for Chronic Kidney Disease in the 21st Century.

Seminars in nephrology. 2016 Nov;36(6):436-447;

Authors: Breyer MD, Susztak K

The next generation of therapeutics for chronic kidney disease.

Nature reviews. Drug discovery. 2016 Aug;15(8):568-88 Epub 2016 May 27;

Authors: Breyer MD, Susztak K

Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog.

Nature reviews. Nephrology. 2016 Jul;12(7):426-39 Epub 2016 May 3;

Authors: Edeling M, Ragi G, Huang S, Pavenstädt H, Susztak K

Podocytes: the Weakest Link in Diabetic Kidney Disease?

Current diabetes reports. 2016 May;16(5):45;

Authors: Lin JS, Susztak K

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.

Diabetes. 2016 Mar;65(3):803-17 Epub 2015 Dec 2;

Authors: Teumer A, Tin A, Sorice R, Gorski M, Yeo NC, Chu AY, Li M, Li Y, Mijatovic V, Ko YA, Taliun D, Luciani A, Chen MH, Yang Q, Foster MC, Olden M, Hiraki LT, Tayo BO, Fuchsberger C, Dieffenbach AK, Shuldiner AR, Smith AV, Zappa AM, Lupo A, Kollerits B, Ponte B, Stengel B, Krämer BK, Paulweber B, Mitchell BD, Hayward C, Helmer C, Meisinger C, Gieger C, Shaffer CM, Müller C, Langenberg C, Ackermann D, Siscovick D, DCCT/EDIC, Boerwinkle E, Kronenberg F, Ehret GB, Homuth G, Waeber G, Navis G, Gambaro G, Malerba G, Eiriksdottir G, Li G, Wichmann HE, Grallert H, Wallaschofski H, Völzke H, Brenner H, Kramer H, Mateo Leach I, Rudan I, Hillege HL, Beckmann JS, Lambert JC, Luan J, Zhao JH, Chalmers J, Coresh J, Denny JC, Butterbach K, Launer LJ, Ferrucci L, Kedenko L, Haun M, Metzger M, Woodward M, Hoffman MJ, Nauck M, Waldenberger M, Pruijm M, Bochud M, Rheinberger M, Verweij N, Wareham NJ, Endlich N, Soranzo N, Polasek O, van der Harst P, Pramstaller PP, Vollenweider P, Wild PS, Gansevoort RT, Rettig R, Biffar R, Carroll RJ, Katz R, Loos RJ, Hwang SJ, Coassin S, Bergmann S, Rosas SE, Stracke S, Harris TB, Corre T, Zeller T, Illig T, Aspelund T, Tanaka T, Lendeckel U, Völker U, Gudnason V, Chouraki V, Koenig W, Kutalik Z, O'Connell JR, Parsa A, Heid IM, Paterson AD, de Boer IH, Devuyst O, Lazar J, Endlich K, Susztak K, Tremblay J, Hamet P, Jacob HJ, Böger CA, Fox CS, Pattaro C, Köttgen A

Fat Burning Problem in Cystic Kidneys: an Emerging Common Mechanism of Chronic Kidney Disease.

EBioMedicine. 2016 Mar;5:22-3 Epub 2016 Feb 23;

Authors: Li SY, Susztak K

Sox9-Positive Progenitor Cells Play a Key Role in Renal Tubule Epithelial Regeneration in Mice.

Cell reports. 2016 Feb 2;14(4):861-871 Epub 2016 Jan 14;

Authors: Kang HM, Huang S, Reidy K, Han SH, Chinga F, Susztak K

Deletion of Lkb1 in Renal Tubular Epithelial Cells Leads to CKD by Altering Metabolism.

Journal of the American Society of Nephrology : JASN. 2016 Feb;27(2):439-53 Epub 2015 Jun 8;

Authors: Han SH, Malaga-Dieguez L, Chinga F, Kang HM, Tao J, Reidy K, Susztak K

Validation and genomic interrogation of the MET variant rs11762213 as a predictor of adverse outcomes in clear cell renal cell carcinoma.

Cancer. 2016 Feb 1;122(3):402-10 Epub 2015 Oct 27;

Authors: Hakimi AA, Ostrovnaya I, Jacobsen A, Susztak K, Coleman JA, Russo P, Winer AG, Mano R, Sankin AI, Motzer RJ, Voss MH, Offit K, Purdue M, Pomerantz M, Freedman M, Choueiri TK, Hsieh JJ, Klein RJ

APOL1 Variants: From Parasites to Kidney Function to Cardiovascular Disease.

Arteriosclerosis, thrombosis, and vascular biology. 2016 Feb;36(2):219-20;

Authors: Reiner AP, Susztak K

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.

Nature communications. 2016 Jan 21;7:10023;

Authors: Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, Tin A, Sorice R, Li Y, Taliun D, Olden M, Foster M, Yang Q, Chen MH, Pers TH, Johnson AD, Ko YA, Fuchsberger C, Tayo B, Nalls M, Feitosa MF, Isaacs A, Dehghan A, d'Adamo P, Adeyemo A, Dieffenbach AK, Zonderman AB, Nolte IM, van der Most PJ, Wright AF, Shuldiner AR, Morrison AC, Hofman A, Smith AV, Dreisbach AW, Franke A, Uitterlinden AG, Metspalu A, Tonjes A, Lupo A, Robino A, Johansson Å, Demirkan A, Kollerits B, Freedman BI, Ponte B, Oostra BA, Paulweber B, Krämer BK, Mitchell BD, Buckley BM, Peralta CA, Hayward C, Helmer C, Rotimi CN, Shaffer CM, Müller C, Sala C, van Duijn CM, Saint-Pierre A, Ackermann D, Shriner D, Ruggiero D, Toniolo D, Lu Y, Cusi D, Czamara D, Ellinghaus D, Siscovick DS, Ruderfer D, Gieger C, Grallert H, Rochtchina E, Atkinson EJ, Holliday EG, Boerwinkle E, Salvi E, Bottinger EP, Murgia F, Rivadeneira F, Ernst F, Kronenberg F, Hu FB, Navis GJ, Curhan GC, Ehret GB, Homuth G, Coassin S, Thun GA, Pistis G, Gambaro G, Malerba G, Montgomery GW, Eiriksdottir G, Jacobs G, Li G, Wichmann HE, Campbell H, Schmidt H, Wallaschofski H, Völzke H, Brenner H, Kroemer HK, Kramer H, Lin H, Leach IM, Ford I, Guessous I, Rudan I, Prokopenko I, Borecki I, Heid IM, Kolcic I, Persico I, Jukema JW, Wilson JF, Felix JF, Divers J, Lambert JC, Stafford JM, Gaspoz JM, Smith JA, Faul JD, Wang JJ, Ding J, Hirschhorn JN, Attia J, Whitfield JB, Chalmers J, Viikari J, Coresh J, Denny JC, Karjalainen J, Fernandes JK, Endlich K, Butterbach K, Keene KL, Lohman K, Portas L, Launer LJ, Lyytikäinen LP, Yengo L, Franke L, Ferrucci L, Rose LM, Kedenko L, Rao M, Struchalin M, Kleber ME, Cavalieri M, Haun M, Cornelis MC, Ciullo M, Pirastu M, de Andrade M, McEvoy MA, Woodward M, Adam M, Cocca M, Nauck M, Imboden M, Waldenberger M, Pruijm M, Metzger M, Stumvoll M, Evans MK, Sale MM, Kähönen M, Boban M, Bochud M, Rheinberger M, Verweij N, Bouatia-Naji N, Martin NG, Hastie N, Probst-Hensch N, Soranzo N, Devuyst O, Raitakari O, Gottesman O, Franco OH, Polasek O, Gasparini P, Munroe PB, Ridker PM, Mitchell P, Muntner P, Meisinger C, Smit JH, ICBP Consortium, AGEN Consortium, CARDIOGRAM, CHARGe-Heart Failure Group, ECHOGen Consortium, Kovacs P, Wild PS, Froguel P, Rettig R, Mägi R, Biffar R, Schmidt R, Middelberg RP, Carroll RJ, Penninx BW, Scott RJ, Katz R, Sedaghat S, Wild SH, Kardia SL, Ulivi S, Hwang SJ, Enroth S, Kloiber S, Trompet S, Stengel B, Hancock SJ, Turner ST, Rosas SE, Stracke S, Harris TB, Zeller T, Zemunik T, Lehtimäki T, Illig T, Aspelund T, Nikopensius T, Esko T, Tanaka T, Gyllensten U, Völker U, Emilsson V, Vitart V, Aalto V, Gudnason V, Chouraki V, Chen WM, Igl W, März W, Koenig W, Lieb W, Loos RJ, Liu Y, Snieder H, Pramstaller PP, Parsa A, O'Connell JR, Susztak K, Hamet P, Tremblay J, de Boer IH, Böger CA, Goessling W, Chasman DI, Köttgen A, Kao WH, Fox CS

Epithelial Plasticity versus EMT in Kidney Fibrosis.

Trends in molecular medicine. 2016 Jan;22(1):4-6 Epub 2015 Dec 11;

Authors: Huang S, Susztak K

The long noncoding RNA landscape in hypoxic and inflammatory renal epithelial injury.

American journal of physiology. Renal physiology. 2015 Dec 1;309(11):F901-13 Epub 2015 Sep 23;

Authors: Lin J, Zhang X, Xue C, Zhang H, Shashaty MG, Gosai SJ, Meyer N, Grazioli A, Hinkle C, Caughey J, Li W, Susztak K, Gregory BD, Li M, Reilly MP

Notch1 and Notch2 in Podocytes Play Differential Roles During Diabetic Nephropathy Development.

Diabetes. 2015 Dec;64(12):4099-111 Epub 2015 Aug 20;

Authors: Sweetwyne MT, Gruenwald A, Niranjan T, Nishinakamura R, Strobl LJ, Susztak K

Diabetic kidney disease.

Nature reviews. Disease primers. 2015 Jul 30;1:15018;

Authors: Thomas MC, Brownlee M, Susztak K, Sharma K, Jandeleit-Dahm KA, Zoungas S, Rossing P, Groop PH, Cooper ME

Diet-Induced Podocyte Dysfunction in Drosophila and Mammals.

Cell reports. 2015 Jul 28;12(4):636-47 Epub 2015 Jul 16;

Authors: Na J, Sweetwyne MT, Park AS, Susztak K, Cagan RL

Role of DNA methylation in renal cell carcinoma.

Journal of hematology & oncology. 2015 Jul 22;8:88;

Authors: Shenoy N, Vallumsetla N, Zou Y, Galeas JN, Shrivastava M, Hu C, Susztak K, Verma A

The evolving understanding of the contribution of lipid metabolism to diabetic kidney disease.

Current diabetes reports. 2015 Jul;15(7):40;

Authors: Stadler K, Goldberg IJ, Susztak K

Functional genomic annotation of genetic risk loci highlights inflammation and epithelial biology networks in CKD.

Journal of the American Society of Nephrology : JASN. 2015 Mar;26(3):692-714 Epub 2014 Sep 17;

Authors: Ledo N, Ko YA, Park AS, Kang HM, Han SY, Choi P, Susztak K

SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage genome-wide association study in patients with type 1 diabetes.

Diabetologia. 2015 Mar;58(3):543-8 Epub 2014 Dec 6;

Authors: Germain M, Pezzolesi MG, Sandholm N, McKnight AJ, Susztak K, Lajer M, Forsblom C, Marre M, Parving HH, Rossing P, Toppila I, Skupien J, Roussel R, Ko YA, Ledo N, Folkersen L, Civelek M, Maxwell AP, Tregouet DA, Groop PH, Tarnow L, Hadjadj S

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development.

Nature medicine. 2015 Jan;21(1):37-46 Epub 2014 Dec 1;

Authors: Kang HM, Ahn SH, Choi P, Ko YA, Han SH, Chinga F, Park AS, Tao J, Sharma K, Pullman J, Bottinger EP, Goldberg IJ, Susztak K

'Back and forth' from models to patients to understand kidney disease: an interview with Katalin Susztak.

Disease models & mechanisms. 2014 Dec;7(12):1317-9;

Authors: Susztak K, Cifra A

Sweet debate: fructose versus glucose in diabetic kidney disease.

Journal of the American Society of Nephrology : JASN. 2014 Nov;25(11):2386-8 Epub 2014 May 29;

Authors: Beckerman P, Susztak K

Kick it up a notch: Notch signaling and kidney fibrosis.

Kidney international supplements. 2014 Nov;4(1):91-96;

Authors: Sweetwyne MT, Tao J, Susztak K

Epigenetics: a new way to look at kidney diseases.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2014 Oct;29(10):1821-7 Epub 2014 Mar 27;

Authors: Beckerman P, Ko YA, Susztak K

Kidney cancer is characterized by aberrant methylation of tissue-specific enhancers that are prognostic for overall survival.

Clinical cancer research : an official journal of the American Association for Cancer Research. 2014 Aug 15;20(16):4349-60 Epub 2014 Jun 10;

Authors: Hu CY, Mohtat D, Yu Y, Ko YA, Shenoy N, Bhattacharya S, Izquierdo MC, Park AS, Giricz O, Vallumsetla N, Gundabolu K, Ware K, Bhagat TD, Suzuki M, Pullman J, Liu XS, Greally JM, Susztak K, Verma A

Copy number polymorphisms near SLC2A9 are associated with serum uric acid concentrations.

BMC genetics. 2014 Jul 9;15:81;

Authors: Scharpf RB, Mireles L, Yang Q, Köttgen A, Ruczinski I, Susztak K, Halper-Stromberg E, Tin A, Cristiano S, Chakravarti A, Boerwinkle E, Fox CS, Coresh J, Linda Kao WH

Molecular mechanisms of diabetic kidney disease.

The Journal of clinical investigation. 2014 Jun;124(6):2333-40 Epub 2014 Jun 2;

Authors: Reidy K, Kang HM, Hostetter T, Susztak K

A multicolor podocyte reporter highlights heterogeneous podocyte changes in focal segmental glomerulosclerosis.

Kidney international. 2014 Apr;85(4):972-80 Epub 2013 Nov 27;

Authors: Tao J, Polumbo C, Reidy K, Sweetwyne M, Susztak K

Notch ties a knot on fistula maturation.

Journal of the American Society of Nephrology : JASN. 2014 Apr;25(4):648-50 Epub 2014 Jan 30;

Authors: Dember LM, Susztak K

DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC study.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2014 Apr;29(4):864-72 Epub 2014 Feb 9;

Authors: Wing MR, Devaney JM, Joffe MM, Xie D, Feldman HI, Dominic EA, Guzman NJ, Ramezani A, Susztak K, Herman JG, Cope L, Harmon B, Kwabi-Addo B, Gordish-Dressman H, Go AS, He J, Lash JP, Kusek JW, Raj DS, Chronic Renal Insufficiency Cohort (CRIC) Study

The hyperglycemic and hyperinsulinemic combo gives you diabetic kidney disease immediately. Focus on "Combined acute hyperglycemic and hyperinsulinemic clamp induced profibrotic and proinflammatory responses in the kidney".

American journal of physiology. Cell physiology. 2014 Feb 1;306(3):C198-9 Epub 2013 Dec 11;

Authors: Han SH, Susztak K

Understanding the epigenetic syntax for the genetic alphabet in the kidney.

Journal of the American Society of Nephrology : JASN. 2014 Jan;25(1):10-7 Epub 2013 Oct 31;

Authors: Susztak K

ADCK4 "reenergizes" nephrotic syndrome.

The Journal of clinical investigation. 2013 Dec;123(12):4996-9 Epub 2013 Nov 25;

Authors: Malaga-Dieguez L, Susztak K

Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags.

Nature medicine. 2013 Dec;19(12):1661-6 Epub 2013 Nov 24;

Authors: Hackl MJ, Burford JL, Villanueva K, Lam L, Suszták K, Schermer B, Benzing T, Peti-Peterdi J

Sirt1-Claudin-1 crosstalk regulates renal function.

Nature medicine. 2013 Nov;19(11):1371-2;

Authors: Nihalani D, Susztak K

Diabetic nephropathy: a national dialogue.

Clinical journal of the American Society of Nephrology : CJASN. 2013 Sep;8(9):1603-5 Epub 2013 Jun 20;

Authors: Breyer MD, Coffman TM, Flessner MF, Fried LF, Harris RC, Ketchum CJ, Kretzler M, Nelson RG, Sedor JR, Susztak K, Kidney Research National Dialogue (KRND)

Epigenomics: the science of no-longer-junk DNA. Why study it in chronic kidney disease?

Seminars in nephrology. 2013 Jul;33(4):354-62;

Authors: Ko YA, Susztak K

For better or worse: a niche for Notch in parietal epithelial cell activation.

Kidney international. 2013 Jun;83(6):988-90;

Authors: Sweetwyne MT, Susztak K

Adiponectin promotes functional recovery after podocyte ablation.

Journal of the American Society of Nephrology : JASN. 2013 Feb;24(2):268-82 Epub 2013 Jan 18;

Authors: Rutkowski JM, Wang ZV, Park AS, Zhang J, Zhang D, Hu MC, Moe OW, Susztak K, Scherer PE

Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development.

Genome biology. 2013;14(10):R108;

Authors: Ko YA, Mohtat D, Suzuki M, Park AS, Izquierdo MC, Han SY, Kang HM, Si H, Hostetter T, Pullman JM, Fazzari M, Verma A, Zheng D, Greally JM, Susztak K

Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development.

PloS one. 2013;8(4):e60244 Epub 2013 Apr 1;

Authors: Wang Y, Wu B, Chamberlain AA, Lui W, Koirala P, Susztak K, Klein D, Taylor V, Zhou B

Emerging role of autophagy in kidney function, diseases and aging.

Autophagy. 2012 Jul 1;8(7):1009-31 Epub 2012 Jun 13;

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Repair problems in podocytes: Wnt, Notch, and glomerulosclerosis.

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Notch in the kidney: development and disease.

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Transcriptome analysis of human diabetic kidney disease.

Diabetes. 2011 Sep;60(9):2354-69 Epub 2011 Jul 13;

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Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival.

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Fetal environment, epigenetics, and pediatric renal disease.

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Tracing the footsteps of glomerular insulin signaling in diabetic kidney disease.

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The story of Notch and chronic kidney disease.

Current opinion in nephrology and hypertension. 2011 Jan;20(1):56-61;

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Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans.

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A susceptibility gene for kidney disease in an obese mouse model of type II diabetes maps to chromosome 8.

Kidney international. 2010 Sep;78(5):453-62 Epub 2010 Jun 2;

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Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function.

Kidney international. 2010 Sep;78(5):514-22 Epub 2010 Jun 9;

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Fine tuning gene expression: the epigenome.

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Getting a notch closer to understanding diabetic kidney disease.

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Localization of the GLUT8 glucose transporter in murine kidney and regulation in vivo in nondiabetic and diabetic conditions.

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