Perelman School of Medicine at the University of Pennsylvania

Titchenell Lab

About the PI

Paul TitchenellPaul Titchenell, Ph.D. earned his Ph.D. for the Pennsylvania State University, in the laboratory of Dr. David Antonetti. During his graduate training, he investigated the signaling mechanisms responsible for diabetic vascular complications, with a particular focus on diabetic retinopathy. During this time, Dr. Titchenell identified and patented a series of small molecular kinase inhibitors that demonstrated pre-clinical efficacy for the treatment of retinal edema induced by pro-inflammatory and angiogenic growth factors.

 Following his Ph.D. studies, Dr. Titchenell trained as a NRSA-supported postdoctoral fellow with Dr. Morris Birnbaum at the Perelman School of Medicine at the University of Pennsylvania. Here, he developed several novel mouse models to dissect the tissue-specific actions of insulin in the regulation of hepatic metabolism. He authored several publications in high-impact journals such as Cell, Cell Metabolism, and Nature Communications. 

In 2016, Dr. Titchenell, under the mentorship of Dr. Mitchell Lazar, was awarded a Career Development Award from the NIDDK to investigate the role of glucose signaling and the regulation of the hepatic transcription.

On July 1, 2017, Dr. Titchenell was appointed as an Assistant Professor of Physiology in the Perelman School of Medicine at the University of Pennsylvania. 

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