Perelman School of Medicine at the University of Pennsylvania

Titchenell Lab

About the PI

Paul TitchenellPaul Titchenell, Ph.D. leads an academic research group focused on how nutrients, growth factors and metabolites regulate metabolism in health and disease. Dr. Titchenell earned his B.S. in Biochemistry and Molecular Biology from Dickinson College. Following his undergraduate studies, Dr. Titchenell obtained a Ph.D. from Pennsylvania State University. During his graduate training, he investigated the signaling mechanisms responsible for diabetic vascular complications and identified and patented a series of small molecular kinase inhibitors for the treatment of retinal edema induced by pro-inflammatory and angiogenic growth factors. Following his Ph.D. studies, Dr. Titchenell trained as a NRSA-supported postdoctoral fellow with Dr. Morris Birnbaum where he developed several novel mouse models to dissect the tissue-specific actions of insulin in the control of hepatic lipid and glucose metabolism. 

In 2017, Dr. Titchenell joined the faculty at the Perelman School of Medicine at the University of Pennsylvania and is currently an Associate Professor (with tenure) in the Department of Physiology and Institute for Diabetes, Obesity, and Metabolism at Penn. Dr. Titchenell also serves as a Co-Director for the Rodent Metabolic Phenotyping Core at the University of Pennsylvania. Dr. Titchenell has published over 40 refereed manuscripts in the world’s leading scientific journals, including Cell, Science, Nature, and Journal of Clinical Investigation. In his own laboratory, Dr. Titchenell’s research is focused on hormone and nutrient signaling in the regulation of glucose, fat and protein metabolism with a particular focus on skeletal muscle biology in health and metabolic diseases such as obesity. Throughout his career, Dr. Titchenell has been active in national and international societies including serving on the Planning Committee for American Diabetes Association Scientific Sessions. He is currently on the Editorial Board for Diabetes and is a recent recipient of the American Physiological Society’s New Investigator Award for Excellence in Endocrinology and Metabolism research.

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