Wangensteen Lab

  • Image of liver staining for FAH

    Liver staining for FAH

  • Philadelphia Skyline
  • Immunofluorescence staining

    Immunofluorescence staining showing repopulating hepatocytes (Green label), pericentral hepatocytes (Red), and overlap (Yellow)

Welcome to the Wangensteen Lab

 

Our lab is conducting exciting research on the genetics of liver repopulation and hepatocellular carcinoma (HCC). We have developed two highly innovative in vivo genetic screening paradigms to elucidate genetic pathways involved in carcinogenesis and liver repopulation in the setting of toxic injury. We aim to discover pathways that lead to drug sensitivity and resistance in HCC.  One of our assays involves CRISPR activation screening in vivo in the liver, the first-ever use of this type of screening in live mice.


image depicting in vivo screening approach

 

Announcements

Thank you Jie for your hard work this year in the Wangensteen Lab! We will miss you!

Hurray for Julia, award winner for her abstract at the Digestive Diseases Center Symposium on April 15, 2019, "Identification of effectors of TNFα signaling that modulate liver repopulation by high throughput in vivo CRISPRa screening"!

Congratulations Morgan for being selected for a travel award and an oral presentation for abstract, "LXR agonism and Sorafenib treatment as novel combination therapy for hepatocellular carcinoma", and also for chairing a session at the Experimental Biology 2019 meeting! Way to go!

Morgan receiving award

Our review, "Liver Cancer Gene Discovery Using Gene Targeting, Sleeping Beauty, and CRISPR/Cas9" is now published!

The Wangensteen Lab welcomes rotation student Alexandra Vazques Salgado.

Congratulations to the Wangensteen and the Raabe labs for being awarded a grant through ITMAT’s Transdisciplinary Awards Program in Translational Medicine and Therapeutics, for the proposal "Strategy to safely repopulate the uninjured host liver with engineered hepatocytes"!!!

© The Trustees of the University of Pennsylvania | Site best viewed in a supported browser. | Site Design: PMACS Web Team.