Wangensteen Lab

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Selected Publications

Multigene Panel Testing in Individuals With Hepatocellular Carcinoma Identifies Pathogenic Germline Variants

Mezina A, Philips N, Bogus Z, Erez N, Xiao R, Fan R, Olthoff KM, Reddy KR, Samadder NJ, Nielsen SM, Hatchell KE, Esplin ED, Rustgi AK, Katona BW, Hoteit MA, Nathanson KL, Wangensteen KJ

JCO Precision Oncology. 2021 June

Aspirin in hepatocellular carcinoma.

Ricciotti E, Wangensteen KJ, FitzGerald, GA

Cancer Res. 2021 Apr 23, Online ahead of print

Multiple roles for hepatitis B and C viruses and the host in the development of hepatocellular carcinoma.

Wangensteen KJ, Chang KM

Hepatology. 2021 Jan; 73 Suppl 1: 27-37

Incapacitated Capicua in Sorafenib-Resistant HCC

Yin D, Wangensteen KJ

Cell Mol Gastroenterol Hepatol. 2020. Apr 27.

Inflammasome-more Injury in Cholestasis.

Zhao X*, Wangensteen KJ*

Cell Mol Gastroenterol Hepatol. 2020. Mar 7. *co-corresponding.

High-content Screen Identifies MicroRNAs Required for Liver Repopulation After Injury in Mice

Zahm AM, Wang AW, Wang YJ, Schug, J, Wangensteen KJ*, Kaestner KH*

Gastroneterology. 2020. Mar. * co-corresponding.

The Dynamic Chromatin Architecture of the Regenerating Liver.

Wang AW, Wang YJ, Zahm AM, Morgan AR, Wangensteen KJ, Kaestner KH.

Cell Mol Gastroenterol Hepatol. 2020; 9(1)

Cell Type-specific Gene Expression Profiling in the Mouse Liver.

Wang AW, Zahm AM, Wangensteen KJ.

J. Vis. Exp. 2019 Sep 17; (151)

Liver Cancer Gene Discovery Using Gene Targeting, Sleeping Beauty, and CRISPR/Cas9

Kieckhaefer JE, Maina F, Wells RG, Wangensteen KJ.

Seminars in Liver Disease. 2019 May;39(2):261-274. 10.1055/s-0039-1678725. 

Combinatorial genetics in liver repopulation and carcinogenesis with a novel in vivo CRISPR activation platform

Wangensteen KJ, Wang YJ, Dou Z, Wang AW, Mosleh-Shirazi E, Horlbeck MA, Gilbert LA, Weissman JS, Berger SL, Kaestner KH.

Hepatology. 2018 Aug;68(2):663-676

Subepithelial telocytes are an important source of Wnts that supports intestinal crypts

Shoshkes-Carmel M, Wang YJ, Wangensteen KJ, Tóth B, Kondo A, Massassa EE, Itzkovitz S, Kaestner KH.

Nature. 2018 May;557(7704):242-246

Endoscopic Band Ligation to Treat a Massive Hemorrhoidal Hemorrhage Following a Transrectal Ultrasound-Guided Prostate Biopsy.

Mahmud N, Wangensteen KJ.

Ann Coloproctol. 2018 Feb;34(1):47-51.

TRAP-seq identifies cystine/glutamate antiporter as a driver of recovery from liver injury

Wang AW*, Wangensteen KJ*, Wang YJ, Zahm AM, Moss NG, Erez N, Kaestner KH.

The Journal of clinical investigation. 2018 Jun 1;128(6):2297-2309. * co-first authors.

Insulin-like growth factor 2 is a key mitogen driving liver repopulation in mice

Wang Min-Jun, Chen Fei, Liu Qing-Gui, Liu Chang-Cheng, Yao Hao, Yu Bing, Zhang Hai-Bin, Yan He-Xin, Ye Yibiao, Chen Tao, Wangensteen Kirk J, Wang Xin, Hu Yi-Ping, He Zhi-Ying

Cell death & disease. 9(2): 26, Jan 2018

Cytoplasmic chromatin triggers inflammation in senescence and cancer.

Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL.

Nature. 2017 Oct 19;550(7676):402-406.

Genetic lineage tracing analysis of the cell of origin of hepatotoxin-induced liver tumors in mice.

Shin S*, Wangensteen KJ*, Teta-Bissett M*, Wang YJ, Mosleh-Shirazi E, Buza EL, Greenbaum LE, Kaestner KH.

Hepatology. 2016 Oct;64(4):1163-1177. * co-first authors

Natural History of Patients Presenting with Autoimmune Hepatitis and Coincident Nonalcoholic Fatty Liver Disease.

De Luca-Johnson J, Wangensteen KJ, Hanson J, Krawitt E, Wilcox R.

Dig Dis Sci. 2016 Sep;61(9):2710-20.

Active recombinant Tol2 transposase for gene transfer and gene discovery applications.

Ni J, Wangensteen KJ, Nelsen D, Balciunas D, Skuster KJ, Urban MD, Ekker SC.

Mob DNA. 2016 Mar 31;7:6.

A genetic screen reveals Foxa3 and TNFR1 as key regulators of liver repopulation.

Wangensteen KJ, Zhang S, Greenbaum LE, Kaestner KH.

Genes Dev. 2015 May 1;29(9):904-9.

Idiopathic Myointimal Hyperplasia of the Mesenteric Veins Diagnosed Preoperatively.

Wangensteen KJ, Fogt F, Kann BR, Osterman MT.

J Clin Gastroenterol. 2015 Jul;49(6):491-4.

A facile method for somatic, lifelong manipulation of multiple genes in the mouse liver.

Wangensteen KJ, Wilber A, Keng VW, He Z, Matise I, Wangensteen L, Carson CM, Chen Y, Steer CJ, McIvor RS, Largaespada DA, Wang X, Ekker SC.

Hepatology. 2008 May;47(5):1714-24.

Messenger RNA as a source of transposase for sleeping beauty transposon-mediated correction of hereditary tyrosinemia type I.

Wilber A*, Wangensteen KJ*, Chen Y, Zhuo L, Frandsen JL, Bell JB, Chen ZJ, Ekker SC, McIvor RS, Wang X.

Mol Ther. 2007 Jul;15(7):1280-7. * co-first authors.

Harnessing a high cargo-capacity transposon for genetic applications in vertebrates.

Balciunas D, Wangensteen KJ, Wilber A, Bell J, Geurts A, Sivasubbu S, Wang X, Hackett PB, Largaespada DA, McIvor RS, Ekker SC.

PLoS Genet. 2006 Nov 10;2(11):e169.


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