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The following publications have resulted from the MDRCC activities to date:
Akima H, Lott D, Senesac C, Deol J, Germain S, Arpan I, Bendixen R, Lee Sweeney H, Walter G,Vandenborne K: Relationships of thigh muscle contractile and non-contractile tissue with function,strength, and age in boys with Duchenne muscular dystrophy, Neuromuscul Disord 2012, 22:16-25
Barton, ER, James, JK, Park, S, Makarewich ,C, Philippou, A, Lei, H, Brisson, B, Eletto, D, Ostrovsky, O, Li, Z and Argon, Y. Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production. Faseb J, in press. 2012
Bish LT, Sleeper MM, Forbes SC, Wang B, Reynolds C, Singletary GE, Trafny D, Morine KJ, Sanmiguel J, Cecchini S, Virag T, Vulin
A, Beley C, Bogan J, Wilson JM, Vandenborne K, KornegayJN, Walter GA, Kotin RM, Garcia L, Sweeney HL: Long-term restoration of cardiac dystrophinexpression in golden retriever muscular dystrophy following rAAV6-mediated exon skipping, Mol Ther 2012, 20:580-589.
Finanger EL, Russman B, Forbes SC, Rooney WD, Walter GA, Vandenborne K: Use of skeletal muscle,MRI in diagnosis and monitoring disease progression in Duchenne muscular dystrophy, Phys Med Rehabil Clin N Am 2012, 23:1-10, ix.
Marshall JL, Chou E, Oh J, Kwok A, Burkin DJ and Crosbie-Watson RH “Dystrophinand utrophin expression requires sarcospan: loss of a7 integrin exacerbates a newly discovered musclephenotype in sarcospan-null mice.” Hum. Mol. Genet., in revision. (core was acknowledged for work performed). 2012
McNally EM, Goldstein JA. Interplay between heart and skeletal muscle disease. 2012 Circ. Res.110(5): 749-54. PMC3305258
McNally EM. Broken Giant linked to Heart Failure Nature 2012 483:281-2. PMCID in progress.
Rooney W, Forbes S, Pollaro J, Wang D-J, de Vos S, Triplett W, Meyer J, Willcocks R, Byrne B, Finkel R, Russman B, Sweeney L, Walter G, and Vandenborne K. Water T2 Values are Elevated in Duchenne Muscular Dystrophy Independent of Fat Infiltration. Proc. Intl. Soc. Magn. Reson. Med. Melbourne Australia May 5-11, 2012
Selsby JT, Morine KJ, Pendrak K, Barton ER, Sweeney HL. PLoS One. 2012;7(1):e30063.
Bish LT, Sleeper MM, Forbes SC, Morine KJ, Reynolds C, Singletary GE, Trafny D, Pham J, Bogan J,Kornegay JN, Vandenborne K, Walter GA, Sweeney HL: Long-term systemic myostatin inhibition via liver-targeted gene transfer in golden retriever muscular dystrophy, Hum Gene Ther 2011, 22:1499-1509
McNally EM, Goldstein JA. Interplay between heart and skeletal muscle disease. 2012 Circ. Res.110(5): 749-54. PMC3305258
Bish LT, Yarchoan M, Sleeper MM, Gazzara JA, Morine KJ, Acosta P, Barton ER, and Sweeney HL. 2011 Chronic Losartan Administration Reduces Mortality and Preserves Cardiac but Not Skeletal Muscle Function in Dystrophic Mice. PLoS ONE 6(6): e20856. PMCID: PMC3120761
Bish LT, Yarchoan M, Sleeper MM, Gazzara JA, Morine KJ, Acosta P, Barton ER, Sweeney HL.Chronic losartan administration reduces mortality and preserves cardiac but not skeletal muscle function in dystrophic mice. PLoS One. 2011;6(6):e20856.
Forbes SC, Lott D, Finkel R, Senesac C, Byrne B, Sweeney HL, Walter GA, VandenborneK. MRI/MRS evaluation of a female carrier of Duchenne muscular dystrophy, Neuromuscular Disorder,Accepted
Lorts A, Schwanekamp JA, McNally EM, Molkentin JD. Deletion of periostin protects against muscular dystrophy in mice by modulating the transforming growth factor-b pathway. (in press, PNAS).
McNally EM, Sparano D. Mechanisms and management of the heart in myotonic dystrophy. Heart. 2011 97(13):1094-100. PMCID
Puckelwartz MJ, Depreux FF, McNally EM. Gene expression, chromosome position and lamin A/C mutations. Nucleus. 2011 2(3):162-167. PMC3149875
Townsend D, Yasuda S, McNally EM, Metzger JM. Distinct pathophysiological mechanisms of cardiomyopathy in hearts lacking dystrophin or the sarcoglycan complex. FASEB J. 2011 9:3106-14. PMC3157690
Morine KJ, Bish LT, Selsby JT, Gazzara, JA, Pendrak K, Sleeper MM, Barton ER, Lee SJ, Sweeney HL. 2010 Activin IIB receptor blockade attenuates dystrophic pathology in a mouse model of Duchenne muscular dystrophy. Muscle Nerve 42(5): 722-30. PMCID
Morris CA, Selsby JT, Morris LD, Pendrak K, Sweeney HL. 2010 Bowman-Birk inhibitor attenuates dystrophic pathology in mdx mice. J Appl Physiol. 109:1492-9. PMCID: PMC2980370
Qaisar R, Renaud G, Morine K, Barton ER, Sweeney HL, Larsson L. Is functional hypertrophy and specific force coupled with addition of myonuclei at the single muscle fiber level? Faseb J, 2010 Mar;26(3):1077-8.Rescue of dystrophic skeletal muscle by PGC-1α involves a fast to slow fiber type shift in the mdxmouse.
Selsby J, Pendrak K, Zadel M, Tian Z, Pham J, Carver T, Acosta P, Barton E, Sweeney HL. 2010 Leupeptin-based inhibitors do not improve the mdx phenotype. Am J Physiol Regul Integr Comp Physiol. 299(5): R1192-201. PMCID:
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