Noam A. Cohen, M.D., PhD
Ralph Butler Endowed Professor for Medical Research
Department: Otorhinolaryngology: Head and Neck Surgery
Graduate Group Affiliations
Contact information
UPHS, Department of ORL:HNS
3400 Spruce Street, 5 Ravdin
Philadelphia, PA 19104-4283
3400 Spruce Street, 5 Ravdin
Philadelphia, PA 19104-4283
Email:
cohenn@uphs.upenn.edu
cohenn@uphs.upenn.edu
Publications
Education:
B.A. (Biology)
Johns Hopkins University , 1990.
Ph.D. (Neuroscience)
Johns Hopkins University , 1998.
M.D. (Medicine)
Johns Hopkins University , 1998.
Permanent linkB.A. (Biology)
Johns Hopkins University , 1990.
Ph.D. (Neuroscience)
Johns Hopkins University , 1998.
M.D. (Medicine)
Johns Hopkins University , 1998.
Description of Research Expertise
Upper airway mucosal innate immunityAirway taste receptors
Respiratory cilia function
respiratory mucosal biofilms
Chronic Rhinosinusitis
Selected Publications
Lee, R.J., Cohen, N.A.: Bitter Taste Bodyguards. Scientific American 314(2): 38-43, February 2016.Lee RJ, Xiong G, Kofonow JM, Chen B, Lysenko A, Jiang P, Abraham V, Doghramji L, Adappa ND, Palmer JN, Kennedy DW, Beauchamp GK, Paschalis-Thomas D, Ischriopoulos H, Kriendler JL, Reed DR, Cohen NA: T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest 122(11): 4145-59, Nov 2012.
Lee RJ, Kofonow JM, Rosen PL, Siebert AP, Chen B, Doghramji L, Xiong G, Adappa ND, Palmer JN, Kennedy DW, Kreindler JL, Margolskee RF, Cohen NA: Bitter and sweet taste receptor regulation of human upper respiratory innate immunity. J Clin Invest 124(3): 1393-405, Mar 2014.
Lee RJ, Workman AD, Carey RM, Chen B, Rosen PL, Doghramji L, Adappa ND, Palmer JN, Kennedy DW, Cohen NA: Fungal Aflatoxins Reduce Respiratory Mucosal Ciliary Function. Nat Sci Rep 14(6): 33221, Sep 2016.
Adappa ND, Farquhar D, Palmer JN, Kennedy DW, Doghramji L, Morris SA, Owens D, Mansfield C, Lysenko A, Lee RJ, Cowart BJ, Reed DR, Cohen NA: TAS2R38 genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis. Int Forum Allergy Rhinol 6(1): 25-33, Jan 2016.
Stevens WW, Lee RJ, Schleimer RP, Cohen NA: Chronic rhinosinusitis pathogenesis. J Allergy Clin Immunol 136(6): 1442-53, Dec 2015.
Adappa AD, Howland TJ, Palmer JN, Kennedy DW, Doghramji L, Lysenko A, Reed DR, Lee RJ, Cohen NA: Genetics of the Taste Receptor T2R38 Correlates with Chronic Rhinosinusitis Necessitating Surgical Intervention. Int Forum Allergy Rhinol 3(3): 184-7, Mar 2013.
Adappa AD, Zhang Z, Palmer JN, Kennedy DW, Doghramji L, Lysenko A, Reed DR, Scott T, Zhao NW, Owens D, Lee RJ, Cohen NA: The Bitter Taste Receptor T2R38 is an Independent Risk Factor for Chronic Rhinosinusitis Requiring Sinus Surgery. Int Forum Allergy Rhinol 4(1): 3-7, Jan 2014.
Adappa ND, Truesdale CM, Workman AD, Doghramji L, Mansfield C, Kennedy DW, Palmer JN, Cowart BJ, Cohen NA: Correlation of T2R38 taste phenotype and in vitro biofilm formation from nonpolypoid chronic rhinosinusitis patients. Int Forum Allergy Rhinol 6(8): 783-91, Aug 2016.
Douglas JE, Saunders CJ, Reed DR, Cohen NA : A role for airway taste receptor modulation in the treatment of upper respiratory infections. Expert Rev Respir Med 10(2): 157-70, Feb 2016.