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Penn Medicine and LouLou Foundation Create Program of Excellence for Rare Genetic Disorder that Affects Children

5 Feb 2016 – The London-based LouLou Foundation and the Orphan Disease Center of the Perelman School of Medicine at the University of Pennsylvania have established a Program of Excellence to develop effective treatments for children with CDKL5, a rare X-chromosome-linked genetic disorder that causes severe... Read more

Penn Study Identifies Enzyme Key to Link Between Age-Related Inflammation and Cancer

2 Feb 2016 – For the first time, researchers have shown that an enzyme key to regulating gene expression -- and also an oncogene when mutated -- is critical for the expression of numerous inflammatory compounds that have been implicated in age-related increases in cancer and tissue degeneration, according to new... Read more

"Gene Fusion" Mutation Uses Three-Way Mechanism To Drive Childhood Brain Cancers

2 Feb 2016 – A powerful, three-way mechanism by which a mutation drives the growth of childhood brain cancers, was discovered by scientists from the Perelman School of Medicine at the University of Pennsylvania and The Children's Hospital of Philadelphia (CHOP). Read more

Viral Gene Editing System Corrects Genetic Liver Disease in Newborn Mice

1 Feb 2016 – For the first time, researchers have treated an animal model of a genetic disorder using a viral vector to deliver genome-editing components in which the disease- causing mutation has been corrected. Read more

Transplant Centers Often Reject Potential Donor Livers for Sickest Patients in Need, says New Penn Medicine Research

27 Jan 2016 – As patients in desperate need of a liver transplant lay waiting, many livers that might give them a new life go unused by centers across the nation, according to new research from the Perelman School of Medicine at the University of Pennsylvania. Read more

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