Rahim R. Rizi, Ph.D.

faculty photo
Professor of Radiology
Department: Radiology
Graduate Group Affiliations

Contact information
Department of Radiology
1 Silverstein
3400 Spruce Street
Philadelphia, PA 19104-6100
Office: 215-573-0891
Fax: 215-349-5115
B.S. (Chemistry)
University of Isfahan, Iran, 1976.
M.S. (Physical Chemistry)
Western Illinois University, 1978.
Ph.D. (Physical Chemistry)
University of Iowa , 1983.
M.S. (Computer Science)
University of Pennsylvania , 1987.
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Description of Research Expertise

The primary mission of the Functional and Metabolic Imaging Group (FMIG) is the development and application of novel hyperpolarized MRI techniques to the diagnosis of various pulmonary and metabolic disorders. Hyperpolarization, the process of drastically increasing the population difference between nuclear spin states, provides a platform for imaging lung physiology and metabolic activity with spatial and temporal resolution unattainable with conventional MRI techniques, thus offering the potential for the earlier diagnosis of disease states and the precise monitoring of a patient’s response to medical treatment. This core research theme is executed with an eye toward several ultimate goals: the identification of changes in pulmonary structure and function associated with disease, a more complete understanding of pathogenesis, and the establishment of a more sensitive testing environment to develop treatments for lung disease. To date, significant contributions in these areas include new imagining techniques for the comprehensive description of lung physiology and structure, accurate imaging of the regional pulmonary partial pressure of oxygen in both humans and large and small animals, highly developed imaging of regional ventilation, and a state-of-the-art mechanical ventilation device. Specifically, our research activities at FMIG is divided into four general branches: 1) The development of novel imaging techniques for the quantitative assessment of pulmonary structure and function: 2)The development of novel methods for real-time metabolic imaging: 3)The construction of novel polarization apparatuses: 4) The development and implementation of rapid imaging pulse sequences.

Selected Publications

Hamedani Hooman, Shaghaghi Hoora, Kadlecek Stephen J, Xin Yi, Han Biao, Siddiqui Sarmad, Rajaei Jennia, Ishii Masaru, Rossman Milton, Rizi Rahim R: Vertical gradients in regional alveolar oxygen tension in supine human lung imaged by hyperpolarized (3) He MRI. NMR in biomedicine 27(12): 1439-50, Dec 2014.

Kadlecek Stephen, Shaghaghi Hoora, Siddiqui Sarmad, Profka Harrilla, Pourfathi Mehrdad, Rizi Rahim: The effect of exogenous substrate concentrations on true and apparent metabolism of hyperpolarized pyruvate in the isolated perfused lung. NMR in biomedicine 27(12): 1557-70, Dec 2014.

Ghosh Rajat K, Kadlecek Stephen J, Pourfathi Mehrdad, Rizi Rahim R: Efficient production of hyperpolarized bicarbonate by chemical reaction on a DNP precursor to measure pH. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Nov 2014.

Hamedani Hooman, Kadlecek Stephen J, Ishii Masaru, Xin Yi, Emami Kiarash, Han Biao, Shaghaghi Hoora, Gopstein Diana, Cereda Maurizio, Gefter Warren B, Rossman Milton D, Rizi Rahim R: Alterations of Regional Alveolar Oxygen Tension in Asymptomatic Current Smokers: Assessment with Hyperpolarized (3)He MR Imaging. Radiology Page: 132809, Oct 2014.

Shaghaghi Hoora, Kadlecek Stephen, Deshpande Charuhas, Siddiqui Sarmad, Martinez Daniel, Pourfathi Mehrdad, Hamedani Hooman, Ishii Masaru, Profka Harrilla, Rizi Rahim: Metabolic spectroscopy of inflammation in a bleomycin-induced lung injury model using hyperpolarized 1-(13) C pyruvate. NMR in biomedicine 27(8): 939-47, Aug 2014.

Siddiqui Sarmad, Xin Yi, Emami Kiarash, D'Armiento Jeanine, Shiomi Takayuki, Profka Harrilla, Mongkolwisetwara Puttisarn, Rizi Rahim: Hyperpolarized (3)He diffusion MRI and histology of secreted frizzled related protein-1 (SFRP1) deficient lungs in a Murine model. Magnetic resonance imaging 32(5): 535-40, Jun 2014.

Xu He N, Kadlececk Stephen, Profka Harrilla, Glickson Jerry D, Rizi Rahim, Li Lin Z: Is higher lactate an indicator of tumor metastatic risk? A pilot MRS study using hyperpolarized (13)C-pyruvate. Academic radiology 21(2): 223-31, Feb 2014.

Ardenkjaer-Larsen Jan H, Laustsen Christoffer, Bowen Sean, Rizi Rahim: Hyperpolarized H2 O MR angiography. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 71(1): 50-6, Jan 2014.

Cereda Maurizio, Xin Yi, Emami Kiarash, Huang Jessie, Rajaei Jennia, Profka Harrilla, Han Biao, Mongkolwisetwara Puttisarn, Kadlecek Stephen, Kuzma Nicholas N, Pickup Stephen, Kavanagh Brian P, Deutschman Clifford S, Rizi Rahim R: Positive end-expiratory pressure increments during anesthesia in normal lung result in hysteresis and greater numbers of smaller aerated airspaces. Anesthesiology 119(6): 1402-9, Dec 2013.

Hamedani Hooman, Kadlecek Stephen J, Ishii Masaru, Emami Kiarash, Kuzma Nicholas N, Xin Yi, Rossman Milton, Rizi Rahim R: A variability study of regional alveolar oxygen tension measurement in humans using hyperpolarized (3) He MRI. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 70(6): 1557-66, Dec 2013.

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Last updated: 09/02/2014
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