John Q. Trojanowski, MD, PhD

faculty photo
William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
Center for Neurodegenerative Disease Researh
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building
Philadelphia, PA 19104-4283
Office: 215-662-6399
Fax: 215-349-5909
Lab: 215-662-3292
Education:

University of Vienna, Vienna, Austria, 1969.
B.A. (German)
King's College (1965-1967 & 1969-1970), 1970.

Erasmus University Rotterdam, Rotterdam, The Netherlands, 1974.
Ph.D. (Neuroanatomy)
Tufts University Graduate School of Arts and Sciences, 1976.
M.D.
Tufts University School of Medicine, 1976.
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Description of Research Expertise

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Selected Publications

Portelius Erik, Olsson Bob, Höglund Kina, Cullen Nicholas C, Kvartsberg Hlin, Andreasson Ulf, Zetterberg Henrik, Sandelius Åsa, Shaw Leslie M, Lee Virginia M Y, Irwin David J, Grossman Murray, Weintraub Daniel, Chen-Plotkin Alice, Wolk David A, McCluskey Leo, Elman Lauren, McBride Jennifer, Toledo Jon B, Trojanowski John Q, Blennow Kaj: Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology. Acta neuropathologica 136(3): 363-376, Sep 2018.

Martini-Stoica Heidi, Cole Allysa L, Swartzlander Daniel B, Chen Fading, Wan Ying-Wooi, Bajaj Lakshya, Bader David A, Lee Virginia M Y, Trojanowski John Q, Liu Zhandong, Sardiello Marco, Zheng Hui: TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading. The Journal of experimental medicine Aug 2018.

Shi Min, Tang Lu, Toledo Jon B, Ginghina Carmen, Wang Hua, Aro Patrick, Jensen Poul H, Weintraub Daniel, Chen-Plotkin Alice S, Irwin David J, Grossman Murray, McCluskey Leo, Elman Lauren B, Wolk David A, Lee Edward B, Shaw Leslie M, Trojanowski John Q, Zhang Jing: Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association 14(8): 1052-1062, Aug 2018.

Schmitz Matthias, Villar-Piqué Anna, Llorens Franc, Gmitterová Karin, Hermann Peter, Varges Daniela, Zafar Saima, Lingor Paul, Vanderstichele Hugo, Demeyer Leentje, Stoops Erik, Trojanowski John Q, Lee Virginia M-Y, Zerr Inga: Cerebrospinal Fluid Total and Phosphorylated α-Synuclein in Patients with Creutzfeldt-Jakob Disease and Synucleinopathy. Molecular neurobiology Aug 2018.

McMillan Corey T, Lee Edward B, Jefferson-George Kyra, Naj Adam, Van Deerlin Vivianna M, Trojanowski John Q, Wolk David A: Alzheimer's genetic risk is reduced in primary age-related tauopathy: a potential model of resistance? Annals of clinical and translational neurology 5(8): 927-934, Aug 2018.

Alosco Michael L, Tripodis Yorghos, Fritts Nathan G, Heslegrave Amanda, Baugh Christine M, Conneely Shannon, Mariani Megan, Martin Brett M, Frank Samuel, Mez Jesse, Stein Thor D, Cantu Robert C, McKee Ann C, Shaw Leslie M, Trojanowski John Q, Blennow Kaj, Zetterberg Henrik, Stern Robert A: Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimer's & dementia : the journal of the Alzheimer's Association Jul 2018.

Nativio Raffaella, Donahue Greg, Berson Amit, Lan Yemin, Amlie-Wolf Alexandre, Tuzer Ferit, Toledo Jon B, Gosai Sager J, Gregory Brian D, Torres Claudio, Trojanowski John Q, Wang Li-San, Johnson F Brad, Bonini Nancy M, Berger Shelley L: Publisher Correction: Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease. Nature neuroscience 21(7): 1018, Jul 2018.

Oukoloff Killian, Kovalevich Jane, Cornec Anne-Sophie, Yao Yuemang, Owyang Zachary A, James Michael, Trojanowski John Q, Lee Virginia M-Y, Smith Amos B, Brunden Kurt R, Ballatore Carlo: Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines. Bioorganic & medicinal chemistry letters 28(12): 2180-2183, Jul 2018.

Robinson John L, Lee Edward B, Xie Sharon X, Rennert Lior, Suh EunRan, Bredenberg Colin, Caswell Carrie, Van Deerlin Vivianna M, Yan Ning, Yousef Ahmed, Hurtig Howard I, Siderowf Andrew, Grossman Murray, McMillan Corey T, Miller Bruce, Duda John E, Irwin David J, Wolk David, Elman Lauren, McCluskey Leo, Chen-Plotkin Alice, Weintraub Daniel, Arnold Steven E, Brettschneider Johannes, Lee Virginia M-Y, Trojanowski John Q: Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated. Brain : a journal of neurology 141(7): 2181-2193, Jul 2018.

Deming Yuetiva, Dumitrescu Logan, Barnes Lisa L, Thambisetty Madhav, Kunkle Brian, Gifford Katherine A, Bush William S, Chibnik Lori B, Mukherjee Shubhabrata, De Jager Philip L, Kukull Walter, Huentelman Matt, Crane Paul K, Resnick Susan M, Keene C Dirk, Montine Thomas J, Schellenberg Gerard D, Haines Jonathan L, Zetterberg Henrik, Blennow Kaj, Larson Eric B, Johnson Sterling C, Albert Marilyn, Moghekar Abhay, Del Aguila Jorge L, Fernandez Maria Victoria, Budde John, Hassenstab Jason, Fagan Anne M, Riemenschneider Matthias, Petersen Ronald C, Minthon Lennart, Chao Michael J, Van Deerlin Vivianna M, Lee Virginia M-Y, Shaw Leslie M, Trojanowski John Q, Peskind Elaine R, Li Gail, Davis Lea K, Sealock Julia M, Cox Nancy J, Goate Alison M, Bennett David A, Schneider Julie A, Jefferson Angela L, Cruchaga Carlos, Hohman Timothy J: Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta neuropathologica Jul 2018.

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Last updated: 08/24/2018
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