John Q. Trojanowski, MD, PhD

faculty photo
William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
Center for Neurodegenerative Disease Researh
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building
Philadelphia, PA 19104-4283
Office: 215-662-6399
Fax: 215-349-5909
Lab: 215-662-3292
Education:

University of Vienna, Vienna, Austria, 1969.
B.A. (German)
King's College (1965-1967 & 1969-1970), 1970.

Erasmus University Rotterdam, Rotterdam, The Netherlands, 1974.
Ph.D. (Neuroanatomy)
Tufts University Graduate School of Arts and Sciences, 1976.
M.D.
Tufts University School of Medicine, 1976.
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Description of Research Expertise

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Selected Publications

Mata Ignacio F, Johnson Catherine O, Leverenz James B, Weintraub Daniel, Trojanowski John Q, Van Deerlin Vivianna M, Ritz Beate, Rausch Rebecca, Factor Stewart A, Wood-Siverio Cathy, Quinn Joseph F, Chung Kathryn A, Peterson-Hiller Amie L, Espay Alberto J, Revilla Fredy J, Devoto Johnna, Yearout Dora, Hu Shu-Ching, Cholerton Brenna A, Montine Thomas J, Edwards Karen L, Zabetian Cyrus P: Large-scale exploratory genetic analysis of cognitive impairment in Parkinson's disease. Neurobiology of aging 56: 211.e1-211.e7, Aug 2017.

Irwin D J, Lleó A, Xie S X, McMillan C T, Wolk D, Lee E B, Van Deerlin V M, Shaw L M, Trojanowski J Q, Grossman M: Ante mortem CSF tau levels correlate with post mortem tau pathology in FTLD. Annals of neurology Jul 2017.

McKeith Ian G, Boeve Bradley F, Dickson Dennis W, Halliday Glenda, Taylor John-Paul, Weintraub Daniel, Aarsland Dag, Galvin James, Attems Johannes, Ballard Clive G, Bayston Ashley, Beach Thomas G, Blanc Frédéric, Bohnen Nicolaas, Bonanni Laura, Bras Jose, Brundin Patrik, Burn David, Chen-Plotkin Alice, Duda John E, El-Agnaf Omar, Feldman Howard, Ferman Tanis J, Ffytche Dominic, Fujishiro Hiroshige, Galasko Douglas, Goldman Jennifer G, Gomperts Stephen N, Graff-Radford Neill R, Honig Lawrence S, Iranzo Alex, Kantarci Kejal, Kaufer Daniel, Kukull Walter, Lee Virginia M Y, Leverenz James B, Lewis Simon, Lippa Carol, Lunde Angela, Masellis Mario, Masliah Eliezer, McLean Pamela, Mollenhauer Brit, Montine Thomas J, Moreno Emilio, Mori Etsuro, Murray Melissa, O'Brien John T, Orimo Sotoshi, Postuma Ronald B, Ramaswamy Shankar, Ross Owen A, Salmon David P, Singleton Andrew, Taylor Angela, Thomas Alan, Tiraboschi Pietro, Toledo Jon B, Trojanowski John Q, Tsuang Debby, Walker Zuzana, Yamada Masahito, Kosaka Kenji: Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology 89(1): 88-100, Jul 2017.

Sims Rebecca, van der Lee Sven J, Naj Adam C, Bellenguez Céline, Badarinarayan Nandini, Jakobsdottir Johanna, Kunkle Brian W, Boland Anne, Raybould Rachel, Bis Joshua C, Martin Eden R, Grenier-Boley Benjamin, Heilmann-Heimbach Stefanie, Chouraki Vincent, Kuzma Amanda B, Sleegers Kristel, Vronskaya Maria, Ruiz Agustin, Graham Robert R, Olaso Robert, Hoffmann Per, Grove Megan L, Vardarajan Badri N, Hiltunen Mikko, Nöthen Markus M, White Charles C, Hamilton-Nelson Kara L, Epelbaum Jacques, Maier Wolfgang, Choi Seung-Hoan, Beecham Gary W, Dulary Cécile, Herms Stefan, Smith Albert V, Funk Cory C, Derbois Céline, Forstner Andreas J, Ahmad Shahzad, Li Hongdong, Bacq Delphine, Harold Denise, Satizabal Claudia L, Valladares Otto, Squassina Alessio, Thomas Rhodri, Brody Jennifer A, Qu Liming, Sánchez-Juan Pascual, Morgan Taniesha, Wolters Frank J, Zhao Yi, Garcia Florentino Sanchez, Denning Nicola, Fornage Myriam, Malamon John, Naranjo Maria Candida Deniz, Majounie Elisa, Mosley Thomas H, Dombroski Beth, Wallon David, Lupton Michelle K, Dupuis Josée, Whitehead Patrice, Fratiglioni Laura, Medway Christopher, Jian Xueqiu, Mukherjee Shubhabrata, Keller Lina, Brown Kristelle, Lin Honghuang, Cantwell Laura B, Panza Francesco, McGuinness Bernadette, Moreno-Grau Sonia, Burgess Jeremy D, Solfrizzi Vincenzo, Proitsi Petra, Adams Hieab H, Allen Mariet, Seripa Davide, Pastor Pau, Cupples L Adrienne, Price Nathan D, Hannequin Didier, Frank-García Ana, Levy Daniel, Chakrabarty Paramita, Caffarra Paolo, Giegling Ina, Beiser Alexa S, Giedraitis Vilmantas, Hampel Harald, Garcia Melissa E, Wang Xue, Lannfelt Lars, Mecocci Patrizia, Eiriksdottir Gudny, Crane Paul K, Pasquier Florence, Boccardi Virginia, Henández Isabel, Barber Robert C, Scherer Martin, Tarraga Lluis, Adams Perrie M, Leber Markus, Chen Yuning, Albert Marilyn S, Riedel-Heller Steffi, Emilsson Valur, Beekly Duane, Braae Anne, Schmidt Reinhold, Blacker Deborah, Masullo Carlo, Schmidt Helena, Doody Rachelle S, Spalletta Gianfranco, Jr W T Longstreth, Fairchild Thomas J, Bossù Paola, Lopez Oscar L, Frosch Matthew P, Sacchinelli Eleonora, Ghetti Bernardino, Yang Qiong, Huebinger Ryan M, Jessen Frank, Li Shuo, Kamboh M Ilyas, Morris John, Sotolongo-Grau Oscar, Katz Mindy J, Corcoran Chris, Dunstan Melanie, Braddel Amy, Thomas Charlene, Meggy Alun, Marshall Rachel, Gerrish Amy, Chapman Jade, Aguilar Miquel, Taylor Sarah, Hill Matt, Fairén Mònica Díez, Hodges Angela, Vellas Bruno, Soininen Hilkka, Kloszewska Iwona, Daniilidou Makrina, Uphill James, Patel Yogen, Hughes Joseph T, Lord Jenny, Turton James, Hartmann Annette M, Cecchetti Roberta, Fenoglio Chiara, Serpente Maria, Arcaro Marina, Caltagirone Carlo, Orfei Maria Donata, Ciaramella Antonio, Pichler Sabrina, Mayhaus Manuel, Gu Wei, Lleó Alberto, Fortea Juan, Blesa Rafael, Barber Imelda S, Brookes Keeley, Cupidi Chiara, Maletta Raffaele Giovanni, Carrell David, Sorbi Sandro, Moebus Susanne, Urbano Maria, Pilotto Alberto, Kornhuber Johannes, Bosco Paolo, Todd Stephen, Craig David, Johnston Janet, Gill Michael, Lawlor Brian, Lynch Aoibhinn, Fox Nick C, Hardy John, Albin Roger L, Apostolova Liana G, Arnold Steven E, Asthana Sanjay, Atwood Craig S, Baldwin Clinton T, Barnes Lisa L, Barral Sandra, Beach Thomas G, Becker James T, Bigio Eileen H, Bird Thomas D, Boeve Bradley F, Bowen James D, Boxer Adam, Burke James R, Burns Jeffrey M, Buxbaum Joseph D, Cairns Nigel J, Cao Chuanhai, Carlson Chris S, Carlsson Cynthia M, Carney Regina M, Carrasquillo Minerva M, Carroll Steven L, Diaz Carolina Ceballos, Chui Helena C, Clark David G, Cribbs David H, Crocco Elizabeth A, DeCarli Charles, Dick Malcolm, Duara Ranjan, Evans Denis A, Faber Kelley M, Fallon Kenneth B, Fardo David W, Farlow Martin R, Ferris Steven, Foroud Tatiana M, Galasko Douglas R, Gearing Marla, Geschwind Daniel H, Gilbert John R, Graff-Radford Neill R, Green Robert C, Growdon John H, Hamilton Ronald L, Harrell Lindy E, Honig Lawrence S, Huentelman Matthew J, Hulette Christine M, Hyman Bradley T, Jarvik Gail P, Abner Erin, Jin Lee-Way, Jun Gyungah, Karydas Anna, Kaye Jeffrey A, Kim Ronald, Kowall Neil W, Kramer Joel H, LaFerla Frank M, Lah James J, Leverenz James B, Levey Allan I, Li Ge, Lieberman Andrew P, Lunetta Kathryn L, Lyketsos Constantine G, Marson Daniel C, Martiniuk Frank, Mash Deborah C, Masliah Eliezer, McCormick Wayne C, McCurry Susan M, McDavid Andrew N, McKee Ann C, Mesulam Marsel, Miller Bruce L, Miller Carol A, Miller Joshua W, Morris John C, Murrell Jill R, Myers Amanda J, O'Bryant Sid, Olichney John M, Pankratz Vernon S, Parisi Joseph E, Paulson Henry L, Perry William, Peskind Elaine, Pierce Aimee, Poon Wayne W, Potter Huntington, Quinn Joseph F, Raj Ashok, Raskind Murray, Reisberg Barry, Reitz Christiane, Ringman John M, Roberson Erik D, Rogaeva Ekaterina, Rosen Howard J, Rosenberg Roger N, Sager Mark A, Saykin Andrew J, Schneider Julie A, Schneider Lon S, Seeley William W, Smith Amanda G, Sonnen Joshua A, Spina Salvatore, Stern Robert A, Swerdlow Russell H, Tanzi Rudolph E, Thornton-Wells Tricia A, Trojanowski John Q, Troncoso Juan C, Van Deerlin Vivianna M, Van Eldik Linda J, Vinters Harry V, Vonsattel Jean Paul, Weintraub Sandra, Welsh-Bohmer Kathleen A, Wilhelmsen Kirk C, Williamson Jennifer, Wingo Thomas S, Woltjer Randall L, Wright Clinton B, Yu Chang-En, Yu Lei, Garzia Fabienne, Golamaully Feroze, Septier Gislain, Engelborghs Sebastien, Vandenberghe Rik, De Deyn Peter P, Fernadez Carmen Muñoz, Benito Yoland Aladro, Thonberg Hakan, Forsell Charlotte, Lilius Lena, Kinhult-Stählbom Anne, Kilander Lena, Brundin RoseMarie, Concari Letizia, Helisalmi Seppo, Koivisto Anne Maria, Haapasalo Annakaisa, Dermecourt Vincent, Fievet Nathalie, Hanon Olivier, Dufouil Carole, Brice Alexis, Ritchie Karen, Dubois Bruno, Himali Jayanadra J, Keene C Dirk, Tschanz JoAnn, Fitzpatrick Annette L, Kukull Walter A, Norton Maria, Aspelund Thor, Larson Eric B, Munger Ron, Rotter Jerome I, Lipton Richard B, Bullido María J, Hofman Albert, Montine Thomas J, Coto Eliecer, Boerwinkle Eric, Petersen Ronald C, Alvarez Victoria, Rivadeneira Fernando, Reiman Eric M, Gallo Maura, O'Donnell Christopher J, Reisch Joan S, Bruni Amalia Cecilia, Royall Donald R, Dichgans Martin, Sano Mary, Galimberti Daniela, St George-Hyslop Peter, Scarpini Elio, Tsuang Debby W, Mancuso Michelangelo, Bonuccelli Ubaldo, Winslow Ashley R, Daniele Antonio, Wu Chuang-Kuo, Peters Oliver, Nacmias Benedetta, Riemenschneider Matthias, Heun Reinhard, Brayne Carol, Rubinsztein David C, Bras Jose, Guerreiro Rita, Al-Chalabi Ammar, Shaw Christopher E, Collinge John, Mann David, Tsolaki Magda, Clarimón Jordi, Sussams Rebecca, Lovestone Simon, O'Donovan Michael C, Owen Michael J, Behrens Timothy W, Mead Simon, Goate Alison M, Uitterlinden Andre G, Holmes Clive, Cruchaga Carlos, Ingelsson Martin, Bennett David A, Powell John, Golde Todd E, Graff Caroline, De Jager Philip L, Morgan Kevin, Ertekin-Taner Nilufer, Combarros Onofre, Psaty Bruce M, Passmore Peter, Younkin Steven G, Berr Claudine, Gudnason Vilmundur, Rujescu Dan, Dickson Dennis W, Dartigues Jean-François, DeStefano Anita L, Ortega-Cubero Sara, Hakonarson Hakon, Campion Dominique, Boada Merce, Kauwe John Keoni, Farrer Lindsay A, Van Broeckhoven Christine, Ikram M Arfan, Jones Lesley, Haines Jonathan L, Tzourio Christophe, Launer Lenore J, Escott-Price Valentina, Mayeux Richard, Deleuze Jean-François, Amin Najaf, Holmans Peter A, Pericak-Vance Margaret A, Amouyel Philippe, van Duijn Cornelia M, Ramirez Alfredo, Wang Li-San, Lambert Jean-Charles, Seshadri Sudha, Williams Julie, Schellenberg Gerard D: Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature genetics Jul 2017.

Gold Brian T, Brown Christopher A, Hakun Jonathan G, Shaw Leslie M, Trojanowski John Q, Smith Charles D: Clinically silent Alzheimer's and vascular pathologies influence brain networks supporting executive function in healthy older adults. Neurobiology of aging 58: 102-111, Jun 2017.

Henderson Michael X, Chung Charlotte Hiu-Yan, Riddle Dawn M, Zhang Bin, Gathagan Ronald J, Seeholzer Steven H, Trojanowski John Q, Lee Virginia M Y: Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies. The Journal of neuroscience : the official journal of the Society for Neuroscience 37(24): 5870-5884, Jun 2017.

Cornec Anne-Sophie, Monti Ludovica, Kovalevich Jane, Makani Vishruti, James Michael J, Vijayendran Krishna G, Oukoloff Killian, Yao Yuemang, Lee Virginia M-Y, Trojanowski John Q, Smith Amos B, Brunden Kurt R, Ballatore Carlo: Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases. Journal of medicinal chemistry 60(12): 5120-5145, Jun 2017.

Kovacs Gabor G, Xie Sharon X, Lee Edward B, Robinson John L, Caswell Carrie, Irwin David J, Toledo Jon B, Johnson Victoria E, Smith Douglas H, Alafuzoff Irina, Attems Johannes, Bencze Janos, Bieniek Kevin F, Bigio Eileen H, Bodi Istvan, Budka Herbert, Dickson Dennis W, Dugger Brittany N, Duyckaerts Charles, Ferrer Isidro, Forrest Shelley L, Gelpi Ellen, Gentleman Stephen M, Giaccone Giorgio, Grinberg Lea T, Halliday Glenda M, Hatanpaa Kimmo J, Hof Patrick R, Hofer Monika, Hortobágyi Tibor, Ironside James W, King Andrew, Kofler Julia, Kövari Enikö, Kril Jillian J, Love Seth, Mackenzie Ian R, Mao Qinwen, Matej Radoslav, McLean Catriona, Munoz David G, Murray Melissa E, Neltner Janna, Nelson Peter T, Ritchie Diane, Rodriguez Roberta D, Rohan Zdenek, Rozemuller Annemieke, Sakai Kenji, Schultz Christian, Seilhean Danielle, Smith Vanessa, Tacik Pawel, Takahashi Hitoshi, Takao Masaki, Rudolf Thal Dietmar, Weis Serge, Wharton Stephen B, White Charles L, Woulfe John M, Yamada Masahito, Trojanowski John Q: Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG). Journal of neuropathology and experimental neurology Jun 2017.

Gendron Tania F, Daughrity Lillian M, Heckman Michael G, Diehl Nancy N, Wuu Joanne, Miller Timothy M, Pastor Pau, Trojanowski John Q, Grossman Murray, Berry James D, Hu William T, Ratti Antonia, Benatar Michael, Silani Vincenzo, Glass Jonathan D, Floeter Mary Kay, Jeromin Andreas, Boylan Kevin B, Petrucelli Leonard: Phosphorylated neurofilament heavy chain: A biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosis. Annals of neurology Jun 2017.

Paolicelli Rosa C, Jawaid Ali, Henstridge Christopher M, Valeri Andrea, Merlini Mario, Robinson John L, Lee Edward B, Rose Jamie, Appel Stanley, Lee Virginia M-Y, Trojanowski John Q, Spires-Jones Tara, Schulz Paul E, Rajendran Lawrence: TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss. Neuron Jun 2017.

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Last updated: 07/20/2017
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