Ravinder Reddy, PhD

faculty photo
Professor of Radiology
Department: Radiology
Graduate Group Affiliations

Contact information
B1 Stellar-Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104-6100
Office: (215) 898-5708
Fax: (215) 573-2113
Lab: (215) 898-9357
Education:
B.Sc. (Math, Physics, and Chemistry)
Osmania University , 1979.
M.Sc. (Chemistry)
Kakatiya University , 1982.
Ph.D. (Chemistry)
Indian Institute of Technology, 1989.
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Description of Research Expertise

My research interests are in developing novel, multinuclear (23Na, 17O, 13C and 1H) magnetic resonance imaging and spectroscopic techniques for the early diagnosis and quantification of physiological and functional aberrations in pathologies such as arthritis, stroke, cancer and Alzheimer’s disease. Our pulse sequence developmental approaches exploit quadrupolar spin-dynamics, polarization transfer, multiple quantum coherences, indirect detection via chemical exchange and spin-locking T1ρ MRI for studying molecular dynamics in biological tissues in vivo.

Specifically, T1ρ and Sodium MRI techniques are designed to map proteoglycan molecules (e.g. aggrecan) in cartilage as a biomarker for early arthritis in vivo. T1ρ MRI is also targeted to impart novel contrast in various tissue types (brain, connective tissues and tumors), and to detect metabolically produced H217O for studying cerebral blood flow and cerebral oxidative metabolism.

Recent developmental work on chemical exchange saturation transfer (CEST) based MRI methods is focused on measuring endogenous but low concentration metabolites in the brain, such as glutamate, myoinositol and creatine to address central nervous system disorders. In addition, a creatine CEST method is currently being explored to measure high-energy phosphate metabolism in the myocardium in heart disease.

- See more at: http://cmroi.med.upenn.edu/personnel/ravinder-reddy-ph-d/#sthash.qFNreUgo.dpuf

Selected Publications

Cai K, Xu HN, Singh A, Moon L, Haris M, Reddy R, Li L.: Breast Cancer Redox Heterogeneity Detectable with Chemical Exchange Saturation Transfer (CEST) MRI. Mol Imaging Biol May 2014.

1. Haris M, Singh A, Cai K, Kogan F, McGarvey J, DeBrosse C, Zsido GA, Walter RT Witschey WRT, Koomalsingh K, Pilla JJ, Chirinos JA, Ferrari VA, Gorman JH, Hariharan H, Robert Gorman RC, Reddy R. : A Novel Technique for In Vivo Mapping of Myocardial Creatine Kinase Metabolism. Nature Medicine 20: 209, 2014.

Cai K, Singh A, Rolf D, Nanga RP, Haris M, Hariharan H, Gur R, Reddy R.: Mapping glutamate in subcortical brain structures using high-resolution GluCEST MRI NMR in Biomed. 10: 1278, October 2013.

Kogan F, Singh A, Debrosse C, Haris M, Cai K, Nanga RP, Elliott M, Hariharan H, and Reddy R. : Imaging of glutamate in the spinal cord using GluCEST. NeuroImage 77: 262, August 2013.

Kogan F, Haris M, Singh A, Cai K, DeBrosse C, Nanga RPR, Hariharan H, Reddy R. : Method for High-Resolution Imaging of Creatine In vivo Using Chemical Exchange Saturation Transfer. Magn. Reson. Med. Feb 2013.

Cai K, Xu HN, Singh A, Haris M, Reddy R, Li LZ : Characterizing Prostate Tumor Mouse Xenografts with CEST and MT-MRI and Redox Scanning. Adv Exp Med Biol. 765: 39-45, 2013.

Haris M, Nanga RP, Singh A, Cai K, Kogan F, Hariharan H, Reddy R : Exchange rates of creatine kinase metabolites: feasibility of imaging creatine by chemical exchange saturation transfer MRI. NMR Biomed 25((11)): 1305-09, Nov 2012.

Haris M, Singh A, Cai K, Nath K, Crescenzi R, Kogan F, Hariharan H, Reddy R: MICEST: A potential tool for non-invasive detection of molecular changes in Alzheimer's disease. J Neurosci Methods 212((1)): 87-93, Oct 2012.

Singh A, Haris M, Cai K, Kassey VB, Kogan F, Reddy D, Hariharan H, Reddy R.: Chemical exchange saturation transfer magnetic resonance imaging of human knee cartilage at 3 T and 7 T. Magn Reson Med 68((2)): 588, Aug 2012.

Kogan F, Singh A, Cai K, Haris M, Hariharan H, Reddy R. : Investigation of chemical exchange at intermediate exchange rates using a combination of chemical exchange saturation transfer (CEST) and spin-locking methods (CESTrho). Magn. Reson. Med. 68((1)): 107, Jul 2012.

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Last updated: 09/12/2014
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