Kenneth S. Shindler, M.D., Ph.D.

faculty photo
Assistant Professor of Ophthalmology
Department: Ophthalmology
Graduate Group Affiliations

Contact information
Scheie Eye Institute
51 North 39th Street
Philadelphia, PA 19104
Education:
ScB (Biochemistry)
Brown University, Providence, 1991.
MD, PhD (Medicine/Neuroscience)
Washington University, St. Louis, 1999.
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Description of Research Expertise

Dr. Shindler's research is examing potential mechanisms to provide neuroprotection of retinal ganglion cells in optic neuritis. Optic neuritis is an inflammatory disease of the optic nerve that often occurs as part of the neurodegenerative disease multiple sclerosis. Damage to nerve cells can lead to permanent vision loss in these patients. Dr. Shindler's studies are helping to identify new therapies to prevent nerve damage in this disease, and such therapies will also likely have benefits for other neurodegenerative diseases as well.

Keywords
Neuro-ophthalmologic conditions, including optic neuropathies, papilledema, and binocular double vision

Selected Publications

Quinn T, Dutt M, Shindler KS: Optic neuritis and retinal ganglion cell loss in a chronic murine model of multiple sclerosis. Front. Neurol. 2: 50, Aug 2011.

Shindler KS, Chatterjee D, Biswas K, GoyalA, DuttM, Nassrallah M, Khan RS, Das Sarma J: Macrophage-mediated optic neuritis induced by retrograde axonal transport of spike gene recombinant mouse hepatitis virus. J. Neuropathol. Exp. Neurol. 70(6): 470-80, June 2011.

Ashtari M, Cyckowski LL, Monroe JF, Marshall KA, Chung DC, Auricchio A, Simonelli F, Leroy BP, Maguire AM, Shindler KS, Bennett J. : The human visual cortex responds to gene therapy-mediated recovery of retinal function. J. Clin. Invest. 121(6): 2160-8, June 2011.

Shindler KS, Ventura E, Dutt M, Elliott P, Fitzgerald DC, Rostami A: Oral resveratrol reduces neuronal damage in a model of multiple sclerosis. J. of Neuro-Ophthalmol. 30(4): 328-39, Dec 2010.

Dutt M, Tabuena P, Ventura E, Rostami AM, Shindler KS: Timing of corticosteroid therapy is critical to prevent retinal ganglion cell loss in experimental optic neuritis. Invest. Ophthalmol. Vis. Sci. 51(3): 1439-1445, Mar 2010.

Das Sarma J, Kenyon LC, Hingley ST, Shindler KS: Mechanisms of primary axonal damage in a viral model of multiple sclerosis J. Neurosci. 29(33): 10272-10280, Aug 2009.

Shindler KS, Ventura E, Dutt M, Rostami AM: Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis. Exp. Eye Res. 87(3): 208-213, Sept 2008.

Shindler KS, Kenyon LC, Dutt M, Hingley ST, Das Sarma J : Experimental optic neuritis induced by a demyelinating strain of mouse hepatitis virus. J. Virol. 82(17): 8882-8886, Sept 2008.

Shindler KS, Ventura E, Rex, TS, Elliott P, Rostami A: SIRT1 activation confers neuroprotection in experimental optic neuritis. Invest. Ophthalmol. Vis. Sci. 48(8): 3602-3609, August 2007.

Shindler KS, Guan Y, Ventura E, Bennett J, Rostami AM: Retinal ganglion cell loss induced by acute optic neuritis in a relapsing model of multiple sclerosis. Mult. Scler. 12: 526-532, 2006.

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Last updated: 09/09/2014
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