Phoebe S Leboy
Contact information
517 Levy Building
4010 Locust Street
Philadelphia, PA 19104
4010 Locust Street
Philadelphia, PA 19104
Office: 215 898-8933
Fax: 215 898-3695
Fax: 215 898-3695
Publications
Education:
B.S. (Zoology/Chemistry)
Swarthmore College, 1957.
Ph.D. (Biochemistry)
Bryn Mawr College, 1962.
Permanent linkB.S. (Zoology/Chemistry)
Swarthmore College, 1957.
Ph.D. (Biochemistry)
Bryn Mawr College, 1962.
Description of Research Expertise
RESEARCH INTERESTS- molecular biology of bone formation from mesencyhmal stem cells
Key words: adult stem cells, differentiation, bone, osteoporosis, transcription, factors, bone morphogenetic proteins, BMP.
DESCRIPTION OF RESEARCH
1. mechanisms for BMP regulation of transcription; and
2. the role of mesenchymal stem cells in bone repair and osteoporosis.
Selected Publications
Diefenderfer, DL, Osyczka, AM, Reilly, GC, and Leboy, PS: BMP responsiveness in human mesenchymal stem cells. Connective Tissue Research 44: 305-11, 2003.Leboy, PS, Grasso-Knight, G, D’Angelo, M, Volk, SW, Lian, JB, Drissi, H, Stein, GS, and Adams, SL: Smad-Runx interactions during chondrocyte maturation. J. Bone Joint Surgery 83-A: S15-S22, 2001.
D’Angelo, M. Billings, PB, Pacifici, M, Leboy, PS, and Kirsch, T: Authentic matrix vesicles contain active metalloproteases: a role for matrix vesicle-associated MMP-13 in activation of TGF-â J. Biol. Chem. 276: 11347-53, 2001.