Tatyana M. Svitkina, Ph.D.
Graduate Group Affiliations
Contact information
221 Leidy Laboratories
Department of Biology
University of Pennsylvania
415 University Avenue
Philadelphia, PA 19104
Department of Biology
University of Pennsylvania
415 University Avenue
Philadelphia, PA 19104
Office: (215) 898-5736
Email:
svitkina@sas.upenn.edu
svitkina@sas.upenn.edu
Education:
BS/MS
Moscow State University, 1973.
Ph.D.
Cancer Research Center, Moscow, Russia, 1979.
Permanent linkBS/MS
Moscow State University, 1973.
Ph.D.
Cancer Research Center, Moscow, Russia, 1979.
Description of Research Expertise
Research Interests: Roles of the actin cytoskeleton in cell motilityKeywords: Actin cytoskeleton, electron microscopy, cell motility, lamellipodia, filopodia
Research Details: We employ correlative light and electron microscopy of cultured cells to understand the molecular and structural organization of the actin cytoskeleton driving different forms of cell motility, such as protrusion of lamellipodia and filopodia at the leading edge of migrating cells, formation of intercellular junctions and synapses, assembly of contractile actin-myosin bundles, and membrane trafficking.
Lab Personnel: Changsong Yang, Ph.D.; Farida Korobova, Ph.D.; Agnieszka Galinska-Rakoczy, Ph.D.; Roman Gorelik, graduate student; Matthew Hoelzle, graduate student.
Selected Publications
Shemesh Tom, Verkhovsky Alexander B, Svitkina Tatyana M, Bershadsky Alexander D, Kozlov Michael M: Role of focal adhesions and mechanical stresses in the formation and progression of the lamellum interface. Biophysical journal 97(5): 1254-64, Sep 2009.Yang Changsong, Hoelzle Matthew, Disanza Andrea, Scita Giorgio, Svitkina Tatyana: Coordination of membrane and actin cytoskeleton dynamics during filopodia protrusion. PloS one 4(5): e5678, 2009.
Semenova Irina, Burakov Anton, Berardone Neda, Zaliapin Ilya, Slepchenko Boris, Svitkina Tatyana, Kashina Anna, Rodionov Vladimir: Actin dynamics is essential for myosin-based transport of membrane organelles. Current biology : CB 18(20): 1581-6, Oct 2008.
Korobova Farida, Svitkina Tatyana: Arp2/3 complex is important for filopodia formation, growth cone motility, and neuritogenesis in neuronal cells. Molecular biology of the cell 19(4): 1561-74, Apr 2008.
Brevier Julien, Montero David, Svitkina Tatyana, Riveline Daniel: The asymmetric self-assembly mechanism of adherens junctions: a cellular push-pull unit. Physical biology 5(1): 16005, 2008.
Yang Changsong, Czech Lubov, Gerboth Silke, Kojima Shin-ichiro, Scita Giorgio, Svitkina Tatyana: Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells. PLoS biology 5(11): e317, Nov 2007.
Applewhite Derek A, Barzik Melanie, Kojima Shin-Ichiro, Svitkina Tatyana M, Gertler Frank B, Borisy Gary G: Ena/VASP proteins have an anti-capping independent function in filopodia formation. Molecular biology of the cell 18(7): 2579-91, Jul 2007.
Vignjevic Danijela, Kojima Shin-ichiro, Aratyn Yvonne, Danciu Oana, Svitkina Tatyana, Borisy Gary G: Role of fascin in filopodial protrusion. The Journal of cell biology 174(6): 863-75, Sep 2006.
Yang Changsong, Pring Martin, Wear Martin A, Huang Minzhou, Cooper John A, Svitkina Tatyana M, Zigmond Sally H: Mammalian CARMIL inhibits actin filament capping by capping protein. Developmental cell 9(2): 209-21, Aug 2005.
Mejillano Marisan R, Kojima Shin-ichiro, Applewhite Derek Anthony, Gertler Frank B, Svitkina Tatyana M, Borisy Gary G: Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. Cell 118(3): 363-73, Aug 2004.