Mortimer Poncz, MD

faculty photo
Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
3615 Civic Center Blvd.
Division of Hematology
The Children's Hospital of Philadelphia
Abramson Research Bdg. Rm. 317
Philadelphia, PA 19104-4318
Office: (215) 590-3574
Fax: (267) 426-5476
Education:
B.S.
Columbia University, 1972.
M.D.
University of Pennsylvania, 1976.
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Description of Research Expertise

Research Interests
Role of platelets in thrombus development

Key words: platelet; megakaryocyte; hematopoiesis; thrombosis.

Description of Research
My research efforts focus on the megakaryocyte-platelet-thrombus axis. The process by which hematopoietic stem cells differentiate into megakaryocytes, which then release platelets and the function of platelets in thrombosis and inflammation are the central foci of my laboratory. Many of the studies focus on the biology and pathobiology of the platelet-specific proteins, chemokines Platelet Factor 4 (PF4)/Platelet Basic Protein (PBP) and the integrin alphaIIb/beta3 receptor.

Rotation Projects for 2006-2007
1. Murine models of thrombosis.
2. Regulation of megakaryocyte gene expression.
3. Gene therapy lentiviral studies for bleeding disorders. Chemokine sin thrombosis and angiogenesis.

Lab personnel:
1 grad student
1 MD post-doc
3 PhD post-docs
5 lab techs
1 Assist Prof Res

Selected Publications

Skewis Lynell R, Lebedeva Tatiana, Papkov Vyacheslav, Thayer Edward C, Massefski Walter, Cuker Adam, Nagaswami Chandrasekaran, Litvinov Rustem I, Kowalska M Anna, Rauova Lubica, Poncz Mortimer, Weisel John W, Lowery Thomas J, Cines Douglas B: T2 Magnetic Resonance: A Diagnostic Platform for Studying Integrated Hemostasis in Whole Blood-Proof of Concept. Clinical chemistry 60(9): 1174-82, Jun 2014.

Lian Lurong, Suzuki Aae, Hayes Vincent, Saha Sougata, Han Xuemei, Xu Tao, Yates John R, Poncz Mortimer, Kashina Anna, Abrams Charles S: Loss of ATE1-mediated arginylation leads to impaired platelet myosin phosphorylation, clot retraction, and in vivo thrombosis formation. Haematologica 99(3): 554-60, Mar 2014.

Shi Guanfang, Field David J, Ko Kyung-ae, Ture Sara, Srivastava Kalyan, Levy Scott, Kowalska M Anna, Poncz Mortimer, Fowell Deborah J, Morrell Craig N: Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection. The Journal of clinical investigation 124(2): 543-52, Feb 2014.

Sullivan Spencer K, Mills Jason A, Koukouritaki Sevasti B, Vo Karen K, Lyde Randolph B, Paluru Prasuna, Zhao Guoha, Zhai Li, Sullivan Lisa M, Wang Yuhuan, Kishore Siddharth, Gharaibeh Eyad Z, Lambert Michele P, Wilcox David A, French Deborah L, Poncz Mortimer, Gadue Paul: High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia. Blood 123(5): 753-7, Jan 2014.

Kowalska M Anna, Zhao Guohua, Zhai Li, David George, Marcus Stephen, Krishnaswamy Sriram, Poncz Mortimer: Modulation of Protein C Activation by Histones, Platelet Factor 4, and Heparinoids: New Insights Into Activated Protein C Formation. Arteriosclerosis, thrombosis, and vascular biology 34(1): 120-6, Oct 2013.

Suzuki Aae, Shin Jae-Won, Wang Yuhuan, Min Sang H, Poncz Morty, Choi John K, Discher Dennis E, Carpenter Chris L, Lian Lurong, Zhao Liang, Wang Yangfeng, Abrams Charles S: RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy and Platelet Generation. PloS one 8(7): e69315, July 2013.

Siner Joshua I, Iacobelli Nicholas P, Sabatino Denise E, Ivanciu Lacramiora, Zhou Shangzhen, Poncz Mortimer, Camire Rodney M, Arruda Valder R: Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype. Blood 121(21): 4396-403, May 2013.

Lambert Michele P, Sullivan Spencer K, Fuentes Rudy, French Deborah L, Poncz Mortimer: Challenges and promises for the development of donor-independent platelet transfusions. Blood 121(17): 3319-24, Apr 2013.

Zhi Huiying, Rauova Lubica, Hayes Vincent, Gao Cunji, Boylan Brian, Newman Debra K, McKenzie Steven E, Cooley Brian C, Poncz Mortimer, Newman Peter J: Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. Blood 121(10): 1858-67, Mar 2013.

Love Melissa S, Millholland Melanie G, Mishra Satish, Kulkarni Swapnil, Freeman Katie B, Pan Wenxi, Kavash Robert W, Costanzo Michael J, Jo Hyunil, Daly Thomas M, Williams Dewight R, Kowalska M Anna, Bergman Lawrence W, Poncz Mortimer, DeGrado William F, Sinnis Photini, Scott Richard W, Greenbaum Doron C: Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials. Cell host & microbe 12(6): 815-23, Dec 2012.

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Last updated: 07/01/2014
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