Mortimer Poncz, MD

faculty photo
Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
3615 Civic Center Blvd.
Division of Hematology
The Children's Hospital of Philadelphia
Abramson Research Bdg. Rm. 317
Philadelphia, PA 19104-4318
Office: (215) 590-3574
Fax: (267) 426-5476
Education:
B.S.
Columbia University, 1972.
M.D.
University of Pennsylvania, 1976.
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Description of Research Expertise

Research Interests
Role of platelets in thrombus development

Key words: platelet; megakaryocyte; hematopoiesis; thrombosis.

Description of Research
My research efforts focus on the megakaryocyte-platelet-thrombus axis. The process by which hematopoietic stem cells differentiate into megakaryocytes, which then release platelets and the function of platelets in thrombosis and inflammation are the central foci of my laboratory. Many of the studies focus on the biology and pathobiology of the platelet-specific proteins, chemokines Platelet Factor 4 (PF4)/Platelet Basic Protein (PBP) and the integrin alphaIIb/beta3 receptor.

Rotation Projects for 2006-2007
1. Murine models of thrombosis.
2. Regulation of megakaryocyte gene expression.
3. Gene therapy lentiviral studies for bleeding disorders. Chemokine sin thrombosis and angiogenesis.

Lab personnel:
1 grad student
1 MD post-doc
3 PhD post-docs
5 lab techs
1 Assist Prof Res

Selected Publications

Lambert M P, Poncz M: They're not your daddy's inherited platelet disorders anymore. Journal of thrombosis and haemostasis : JTH 11(11): 2037-8, Nov 2013.

Kowalska M Anna, Zhao Guohua, Zhai Li, David George, Marcus Stephen, Krishnaswamy Sriram, Poncz Mortimer: Modulation of Protein C Activation by Histones, Platelet Factor 4, and Heparinoids: New Insights Into Activated Protein C Formation. Arteriosclerosis, thrombosis, and vascular biology Oct 2013.

Suzuki Aae, Shin Jae-Won, Wang Yuhuan, Min Sang H, Poncz Morty, Choi John K, Discher Dennis E, Carpenter Chris L, Lian Lurong, Zhao Liang, Wang Yangfeng, Abrams Charles S: RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy and Platelet Generation. PloS one 8(7): e69315, July 2013.

Siner Joshua I, Iacobelli Nicholas P, Sabatino Denise E, Ivanciu Lacramiora, Zhou Shangzhen, Poncz Mortimer, Camire Rodney M, Arruda Valder R: Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype. Blood 121(21): 4396-403, May 2013.

Lambert Michele P, Sullivan Spencer K, Fuentes Rudy, French Deborah L, Poncz Mortimer: Challenges and promises for the development of donor-independent platelet transfusions. Blood 121(17): 3319-24, Apr 2013.

Zhi Huiying, Rauova Lubica, Hayes Vincent, Gao Cunji, Boylan Brian, Newman Debra K, McKenzie Steven E, Cooley Brian C, Poncz Mortimer, Newman Peter J: Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. Blood 121(10): 1858-67, Mar 2013.

Love Melissa S, Millholland Melanie G, Mishra Satish, Kulkarni Swapnil, Freeman Katie B, Pan Wenxi, Kavash Robert W, Costanzo Michael J, Jo Hyunil, Daly Thomas M, Williams Dewight R, Kowalska M Anna, Bergman Lawrence W, Poncz Mortimer, DeGrado William F, Sinnis Photini, Scott Richard W, Greenbaum Doron C: Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials. Cell host & microbe 12(6): 815-23, Dec 2012.

Ono Yukako, Wang Yuhuan, Suzuki Hidenori, Okamoto Shinichiro, Ikeda Yasuo, Murata Mitsuru, Poncz Mortimer, Matsubara Yumiko: Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf. Blood 120(18): 3812-21, Nov 2012.

Sachais Bruce S, Litvinov Rustem I, Yarovoi Serge V, Rauova Lubica, Hinds Jillian L, Rux Ann H, Arepally Gowthami M, Poncz Mortimer, Cuker Adam, Weisel John W, Cines Douglas B: Dynamic antibody-binding properties in the pathogenesis of HIT. Blood 120(5): 1137-42, Aug 2012.

Lambert M P, Reznikov A, Grubbs A, Nguyen Y, Xiao L, Aplenc R, Rauova L, Poncz M: Platelet factor 4 platelet levels are inversely correlated with steady-state platelet counts and with platelet transfusion needs in pediatric leukemia patients. Journal of thrombosis and haemostasis : JTH 10(7): 1442-6, Jul 2012.

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Last updated: 11/19/2013
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