Andrew Tsourkas, Ph.D.

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Professor of Bioengineering
Department: Bioengineering

Contact information
Department of Bioengineering
University of Pennsylvania
210 S. 33rd Street, 240 Skirkanich Hall
Philadelphia, PA 19104
Office: 215-898-8167
Fax: 215-573-2071
B.S. (Mechanical Engineering)
Cornell University, 1997.
M.S. (Mechanical Engineering)
Johns Hopkins University, 1999.
Ph.D. (Biomedical Engineering)
Georgia Institute of Technology/Emory University, 2004.
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Description of Research Expertise

Research Interests: Developing molecular imaging probes to improve the diagnostic yield of non- or minimally-invasive imaging procedures and diagnostic assays.

Keywords: Molecular imaging, probes, contrast agents, magnetic resonance, fluorescence, bioluminescence

Selected Publications

Elias Drew R, Poloukhtine Andrei, Popik Vladimir, Tsourkas Andrew: Effect of ligand density, receptor density, and nanoparticle size on cell targeting. Nanomedicine : nanotechnology, biology, and medicine Jun 2012.

Czupryna Julie, Tsourkas Andrew: Xanthine oxidase-generated hydrogen peroxide is a consequence, not a mediator of cell death. The FEBS journal 279(5): 844-55, Mar 2012.

Crayton Samuel H, Elias Drew R, Al Zaki Ajlan, Cheng Zhiliang, Tsourkas Andrew: ICP-MS analysis of lanthanide-doped nanoparticles as a non-radiative, multiplex approach to quantify biodistribution and blood clearance. Biomaterials 33(5): 1509-19, Feb 2012.

Crayton Samuel H, Tsourkas Andrew: pH-titratable superparamagnetic iron oxide for improved nanoparticle accumulation in acidic tumor microenvironments. ACS nano 5(12): 9592-601, Dec 2011.

Cheng Zhiliang, Elias Drew R, Kamat Neha P, Johnston Eric D, Poloukhtine Andrei, Popik Vladimir, Hammer Daniel A, Tsourkas Andrew: Improved tumor targeting of polymer-based nanovesicles using polymer-lipid blends. Bioconjugate chemistry 22(10): 2021-9, Oct 2011.

Thorek Daniel L J, Weisshaar Christine L, Czupryna Julie C, Winkelstein Beth A, Tsourkas Andrew: Superparamagnetic iron oxide-enhanced magnetic resonance imaging of neuroinflammation in a rat model of radicular pain. Molecular imaging 10(3): 206-14, Jun 2011.

Czupryna Julie, Tsourkas Andrew: Firefly luciferase and RLuc8 exhibit differential sensitivity to oxidative stress in apoptotic cells. PloS one 6(5): e20073, 2011.

Elias Drew R, Cheng Zhiliang, Tsourkas Andrew: An intein-mediated site-specific click conjugation strategy for improved tumor targeting of nanoparticle systems. Small (Weinheim an der Bergstrasse, Germany) 6(21): 2460-8, Nov 2010.

Chen Antony K, Davydenko Olga, Behlke Mark A, Tsourkas Andrew: Ratiometric bimolecular beacons for the sensitive detection of RNA in single living cells. Nucleic acids research 38(14): e148, Aug 2010.

Thorek Daniel L J, Tsao Patricia Y, Arora Vaishali, Zhou Lanlan, Eisenberg Robert A, Tsourkas Andrew: In vivo, multimodal imaging of B cell distribution and response to antibody immunotherapy in mice. PloS one 5(5): e10655, 2010.

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Last updated: 05/26/2015
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