Elizabeth Rhoades
Professor of Chemistry in Biochemistry and Biophysics
Department: Biochemistry and Biophysics
Graduate Group Affiliations
Contact information
Department of Chemistry
231 S. 34th Street
Philadelphia, PA 19104
231 S. 34th Street
Philadelphia, PA 19104
Office: 215-573-6477
Email:
rhoadese@sas.upenn.edu
rhoadese@sas.upenn.edu
Education:
B.S. (Physics)
Duke University , 1994.
Ph.D. (Biophysics)
University of Michigan, 2001.
none (Mentor Training)
University of Pennsylvania, 2022.
Permanent linkB.S. (Physics)
Duke University , 1994.
Ph.D. (Biophysics)
University of Michigan, 2001.
none (Mentor Training)
University of Pennsylvania, 2022.
Selected Publications
Pan B, Shimogawa M, Zhao J, Rhoades E, Kashina A, Petersson EJ.: Cysteine-Based Mimic of Arginylation Reproduces Neuroprotective Effects of the Authentic Post-Translational Modification on α-Synuclein. J Am Chem Soc 144: 7911-7918, May 2022.Zhao J, Pan B, Fina M, Huang Y, Shimogawa M, Luk KC, Rhoades E, Petersson EJ, Dong DW, Kashina A.: α-Synuclein arginylation in the human brain. Transl Neurodegener 11: 20, Apr 2022.
Cario A, Wickramasinghe SP, Rhoades E, Berger CL.: The N-terminal disease-associated R5L Tau mutation increases microtubule shrinkage rate due to disruption of microtubule-bound Tau patches. J Biol Chem 2022.
Braun AR, Liao EE, Horvath M, Kalra P, Acosta K, Young MC, Kochen NN, Lo CH, Brown R, Evans MD, Pomerantz WCK, Rhoades E, Luk K, Cornea RL, Thomas DD, Sachs JN.: Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors. NPJ Parkinsons Dis 7: 52, Jun 2021.
Pan B, Park JH, Ramlall T, Eliezer D, Rhoades E, Petersson EJ.: Chemoenzymatic Semi-synthesis Enables Efficient Production of Isotopically Labeled α-Synuclein with Site-Specific Tyrosine Phosphorylation. Chembiochem 22: 1440-1447, Apr 2021.
Pan B, Kamo N, Shimogawa M, Huang Y, Kashina A, Rhoades E, Petersson EJ.: Effects of Glutamate Arginylation on α-Synuclein: Studying an Unusual Post-Translational Modification through Semisynthesis. J Am Chem Soc 142: 21786-21798, Dec 2020.
Castle BT, McKibben KM, Rhoades E, Odde DJ.: Tau Avoids the GTP Cap at Growing Microtubule Plus-Ends. iScience 23: 101782, Nov 2020.
Metskas LA, Rhoades E.: Single-Molecule FRET of Intrinsically Disordered Proteins. Annu Rev Phys Chem 71: 391-414, Apr 2020.
Pan B, Rhoades E, Petersson EJ.: Chemoenzymatic Semisynthesis of Phosphorylated α-Synuclein Enables Identification of a Bidirectional Effect on Fibril Formation. ACS Chem Biol 15: 640-645, Mar 2020.
Fung HYJ, McKibben KM, Ramirez J, Gupta K, Rhoades E.: Structural Characterization of Tau in Fuzzy Tau:Tubulin Complexes. Structure 28: 378-384, Mar 2020.