Aalim M. Weljie, Ph.D.

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Research Assistant Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations

Contact information
10-113 Translational Research Center
3400 Civic Center Blvd, Bldg 421
Philadelphia, PA 19104
Office: 215-573-8085
Lab: 215-898-2220
Education:
B.Sc. (Chemistry; Certificate in Engineering)
Mount Allison University, 1996.
Ph.D. (Biochemistry)
University of Calgary, 2002.
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Description of Research Expertise

Our research program has a focus in the development of metabolomics methods and technologies as applied to translational research problems. The biological context of our work is varied with particular emphasis in diabetes and obesity, environmental toxicology, and cancer.

We also have an active program in clinical metabolite profiling. High-throughput metabolite profiling has great potential in the development of clinical diagnostic and prognostic tests, and this power has generated a great deal of interest amongst clinicians. We are involved in a number of highly collaborative clinical studies aimed at using metabolomics methods as an additional tool in the clinic

Selected Publications

Dang NH, Singla AK, Mackay EM, Jirik FR, Weljie AM: Targeted Cancer Therapeutics: Biosynthetic and Energetic Pathways Characterized by Metabolomics and the Interplay with Key Cancer Regulatory Factors. Current Pharmaceutical Design Page: In Press, 2014.

Ngoc-Ha T. Dang, Bo Young Ahn, Laszlo G. Boros, Donna Senger, Aalim M. Weljie: Targeting the distinct roles of acetyl-CoA carboxylase and fatty acid synthase in the fatty acid synthesis pathway of glioblastoma multiformes metabolism. Cold Spring Harbor Symposium: Metabolic Signaling & Disease: from Cell to Organism August 2013.

Athersuch Toby J, Malik Shahid, Weljie Aalim, Newton Jack, Keun Hector C: Evaluation of (1)H NMR Metabolic Profiling Using Biofluid Mixture Design. Analytical chemistry Jun 2013.

Tambellini NP, Zaremberg V, Turner RJ, Weljie AM: Evaluation of Extraction Protocols for Simultaneous Polar and Non-Polar Yeast Metabolite Analysis Using Multivariate Projection Methods. Metabolites 3: 592-605, 2013.

Reimer RA, Maurer AD, Eller LK, Hallam MC, Shaykhutdinov R, Vogel HJ, Weljie AM: Satiety hormone and metabolomic response to an intermittent high energy diet differs in rats consuming long-term diets high in protein or prebiotic fibre. J. Proteome Res. 11(8): 4065-74, August 2012.

Dang, N. Ha, Kalkat, Manpreet, Luchman, Artee2, Oyelusi, Wale2, Senger, Donna, Weljie, Aalim M: Metabolomics approach for characterizing fatty acid synthesis pathway – a target for brain tumour therapies. 8th International Conference of the Metabolomics Society, Washington, DC June 2012 Notes: Oral.

Farshad Farshidfar, Aalim M. Weljie, Karen Kopciuk, Hans J. Vogel, Oliver F. Bathe: Metabolomic Profile of Colorectal Cancer Patients Shows Reproducibility in Pre- Operative and Intra-Operative Conditions. 8th International Meeting of the Metabolomics Society, Washington, DC June 2012 Notes: Oral.

Jeffery Herman: "Metabolomics Continues Auspicious Climb" Genetic Engineering and Biotechnology News 32(9), May 2012 Notes: Interview.

Farshidfar Farshad, Weljie Aalim M, Kopciuk Karen, Buie W Don, Maclean Anthony, Dixon Elijah, Sutherland Francis R, Molckovsky Andrea, Vogel Hans J, Bathe Oliver F: Serum metabolomic profile as a means to distinguish stage of colorectal cancer. Genome medicine 4(5): 42, May 2012.

Luchman H Artee, Stechishin Owen D, Dang N Ha, Blough Michael D, Chesnelong Charles, Kelly John J, Nguyen Stephanie A, Chan Jennifer A, Weljie Aalim M, Cairncross J Gregory, Weiss Samuel: An in vivo patient-derived model of endogenous IDH1-mutant glioma. Neuro-oncology 14(2): 184-91, Feb 2012.

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Last updated: 03/21/2014
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