Stewart A Anderson
Associate Professor of Psychiatry
Department: Psychiatry
Graduate Group Affiliations
Contact information
3615 Civic Center Blvd.
Abramson Research Center
Room 517
Philadelphia, PA 19147
Abramson Research Center
Room 517
Philadelphia, PA 19147
Email:
andersons3@email.chop.edu
andersons3@email.chop.edu
Education:
BA (Neuroscience )
Amherst College, 1984.
MD (Medicine)
University of Connecticut, 1989.
Permanent linkBA (Neuroscience )
Amherst College, 1984.
MD (Medicine)
University of Connecticut, 1989.
Description of Research Expertise
The focus of my laboratory concerns the molecular and cellular mechanisms that govern the development of the mammalian forebrain. We use mouse genetics, forebrain slice and dissociated culture techniques, as well as mouse and human embryonic stem cells in cell culture and transplantation experiments to study the fate determination of interneurons of the cerebral cortex. We are particularly interested in understanding the molecular underpinnings behind the fate determination and axon targeting of subclasses of GABAergic interneurons implicated in the neuropathology of schizophrenia. In addition, we are exploring the use of mouse and human stem cell-derived interneurons in cell-based therapies for seizures, and as tools for the study of gene-gene and gene-environment interactions in neuropsychiatric disease, including schizophrenia and autism.Selected Publications
Goulburn, A. L., Stanley, E. G., Elefanty, A. G., Anderson, S. A.: Generating GABAergic cerebral cortical interneurons from mouse and human embryonic stem cells. Stem Cell Res 8(3): 416-26, 2012.Inan, M., Welagen, J., Anderson, S. A.: Spatial and temporal bias in the mitotic origins of somatostatin- and parvalbumin-expressing interneuron subgroups and the chandelier subtype in the medial ganglionic eminence. Cereb Cortex 22(4): 820-7, 2012.
Inan, M., Petros, T. J., Anderson, S. A.: Losing your inhibition: Linking cortical GABAergic interneurons to schizophrenia. Neurobiol Dis 2012.
Brown, K. N., Chen, S., Han, Z., Lu, C. H., Tan, X., Zhang, X. J., Ding, L., Lopez-Cruz, A., Saur, D., Anderson, S. A., Huang, K., Shi, S. H.: Clonal production and organization of inhibitory interneurons in the neocortex. Science 334(6055): 480-6, 2011.
Woodruff, A. R., McGarry, L. M., Vogels, T. P., Inan, M., Anderson, S. A., Yuste, R.: State-dependent function of neocortical chandelier cells. J Neurosci 31(49): 17872-86, 2011.
Goulburn, A. L., Alden, D., Davis, R. P., Micallef, S. J., Ng, E. S., Yu, Q. C., Lim, S. M., Soh, C. L., Elliott, D. A., Hatzistavrou, T., Bourke, J., Watmuff, B., Lang, R. J., Haynes, J. M., Pouton, C. W., Giudice, A., Trounson, A. O., Anderson, S. A., Stanley, E. G., Elefanty, A. G.: A targeted NKX2.1 human embryonic stem cell reporter line enables identification of human basal forebrain derivatives. Stem Cells 29(3): 462-73, 2011.
De la Cruz, E., Zhao, M., Guo, L., Ma, H., Anderson, S. A., Schwartz, T. H.: Interneuron Progenitors Attenuate the Power of Acute Focal Ictal Discharges. Neurotherapeutics 2011.
Cundiff, P. E., Anderson, S. A.: Impact of induced pluripotent stem cells on the study of central nervous system disease. Curr Opin Genet Dev 21(3): 354-61, 2011.
Maroof, A. M., Brown, K., Shi, S. H., Studer, L., Anderson, S. A.: Prospective isolation of cortical interneuron precursors from mouse embryonic stem cells. J Neurosci 30(13): 4667-75, 2010.
Xu, Q., Guo, L., Moore, H., Waclaw, R. R., Campbell, K., Anderson, S. A.: Sonic hedgehog signaling confers ventral telencephalic progenitors with distinct cortical interneuron fates. Neuron 65(3): 328-40, 2010.