Stewart A Anderson, MD

faculty photo
Associate Professor of Psychiatry
Department: Psychiatry
Graduate Group Affiliations

Contact information
3615 Civic Center Blvd.
Abramson Research Center
Room 517
Philadelphia, PA 19147
Office: 215-590-6527
Fax: 215-590-3709
BA (Neuroscience and Psychology)
Amherst College, Amherst, MA, 1984.
MD (Medicine)
University of Connecticut, Storrs, CT, 1989.
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Description of Research Expertise

The focus of my laboratory concerns the molecular and cellular mechanisms that govern the development of the mammalian forebrain. We use mouse genetics, forebrain slice and dissociated culture techniques, as well as mouse and human pluripotent stem cells in cell culture and transplantation experiments to study the fate determination of interneurons of the cerebral cortex. We are particularly interested in understanding the molecular underpinnings behind the fate determination and axon targeting of subclasses of GABAergic interneurons implicated in the neuropathology of schizophrenia. In addition, we are exploring the use of mouse and human stem cell-derived interneurons in cell-based therapies for seizures, and as tools for the study of gene-gene and gene-environment interactions in neuropsychiatric disease, including schizophrenia and autism.

Selected Publications

Chu J, Anderson SA : Development of Cortical Interneurons. Neuropsychopharmacology 40(1): 16-23, 2015.

Petros TJ, Bultje RS, Ross ME, Fishell G, Anderson SA: Apical vs. basal neurogenesis directs cortical interneuron subclass fate. Cell Reports. In press. Cell Reports in press, 2015.

Jaiswal MK, Keros S, Zhao Z, Inan M, Schwartz TH, Anderson SA, Homanics GE, Goldstein PA : Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit. Frontiers in Cellular Neuroscience 9: 127-134, 2015.

Anderson SA, Parent JM (2015). : Reprogramming patient-derived cells to study the epilepsies. Nature Neuroscience In Press., 2015.

Tyson JA, Goldberg EM, Maroof AM, Xu Q, Petros TJ, Anderson SA.: Duration of culture and Sonic Hedgehog signaling differentially specify PV versus SST cortical interneuron fates from embryonic stem cells. Development In Press., 2015.

Gilani AI, Inan M, Chohan MO; Schobel SA, Chaudhury NH, Chuhma N, Glickstein S, MerkerR, Steinfeld S, Xu Q, Small SA, Anderson SA*, Ross ME*, Moore H*. *corresponding authors. : Interneuron precursor transplants into adult hippocampus reverse psychosis-relevant features in a mouse hippocampal disinhibition model PNAS 111(20): 7450-7455. 2014.

Inan M, Anderson SA: The chandelier cell, form and function. Current Opinion in Neurobiology 26C: 142-148, 2014.

Anderson SA, Vanderhaeghen, P: Cortical neurogenesis from pluripotent stem cells: complexity emerging from simplicity. Current Opinion in Neurobiology 27C: 151-157, 2014.

Radonjic NV, Ayoub AE, Memi F, Yu X, Maroof A, Jakovcevski I, Anderson SA, Rakic P, Zecevic N : Diversity of Cortical Interneurons in Primates: the Role of the Dorsal Proliferative Niche. Cell Reports 9(6): 2139-2151, 2014.

Tyson JA, Anderson SA.: GABAergic Interneuron Transplants to Study Development and Treat Disease. Trends in Neurosciences 73 (3): 169-177, 2014.

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Last updated: 09/14/2015
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