Robert H Mach, Ph.D.

faculty photo
Britton Chance Professor of Radiology
Department: Radiology
Graduate Group Affiliations

Contact information
Department of Radiology
Chemistry Building
231 S. 34th Street
Philadelphia, PA 19104
Office: 215-746-8233
B.A. (Chemistry)
State University of New York, College at Potsdam, 1978.
Ph.D. (Medical Chemistry)
State University of New York at Buffalo, Buffalo, NY, 1985.
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Selected Publications

Sahlholm Kristoffer, Ielacqua Giovanna D, Xu Jinbin, Jones Lynne A, Schlegel Felix, Mach Robert H, Rudin Markus, Schroeter Aileen: The role of beta-arrestin2 in shaping fMRI BOLD responses to dopaminergic stimulation. Psychopharmacology 234(13): 2019-2030, Jul 2017.

Sellmyer Mark A, Lee Iljung, Hou Catherine, Weng Chi-Chang, Li Shihong, Lieberman Brian P, Zeng Chenbo, Mankoff David A, Mach Robert H: Bacterial infection imaging with [(18)F]fluoropropyl-trimethoprim. Proceedings of the National Academy of Sciences of the United States of America Jul 2017.

McDonald Elizabeth S, Mankoff Julia, Makvandi Mehran, Chu Wenhua, Chu Yunxiang, Mach Robert H, Zeng Chenbo: Sigma-2 ligands and PARP inhibitors synergistically trigger cell death in breast cancer cells. Biochemical and biophysical research communications 486(3): 788-795, May 2017.

Yang Dongzhi, Comeau Anthony, Bowen Wayne D, Mach Robert H, Ross Brian D, Hong Hao, Van Dort Marcian E: Design and Investigation of a [(18)F]-Labeled Benzamide Derivative as a High Affinity Dual Sigma Receptor Subtype Radioligand for Prostate Tumor Imaging. Molecular pharmaceutics 14(3): 770-780, Mar 2017.

Zhou Rong, Pantel Austin R, Li Shihong, Lieberman Brian P, Ploessl Karl, Choi Hoon, Blankemeyer Eric, Lee Hsiaoju, Kung Hank F, Mach Robert H, Mankoff David A: [(18)F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition. Cancer research 77(6): 1476-1484, Mar 2017.

Michel Loren S, Dyroff Samantha, Brooks Frank J, Spayd Katherine J, Lim Sora, Engle Jacquelyn T, Phillips Sharon, Tan Benjamin, Wang-Gillam Andrea, Bognar Christopher, Chu Wenhua, Zhou Dong, Mach Robert H, Laforest Richard, Chen Delphine L: PET of Poly (ADP-Ribose) Polymerase Activity in Cancer: Preclinical Assessment and First In-Human Studies. Radiology 282(2): 453-463, Feb 2017.

Zeng Chenbo, McDonald Elizabeth S, Mach Robert H: Molecular Probes for Imaging the Sigma-2 Receptor: In Vitro and In Vivo Imaging Studies. Handbook of experimental pharmacology Feb 2017.

Sander Effron Samuel, Makvandi Mehran, Lin Lilie, Xu Kuiying, Li Shihong, Lee Hsiaoju, Hou Catherine, Pryma Daniel A, Koch Cameron, Mach Robert H: PARP-1 Expression Quantified by [(18)F]FluorThanatrace: A Biomarker of Response to PARP Inhibition Adjuvant to Radiation Therapy. Cancer biotherapy & radiopharmaceuticals 32(1): 9-15, Feb 2017.

Hashim Yassar M, Vangveravong Suwanna, Sankpal Narendra V, Binder Pratibha S, Liu Jingxia, Goedegebuure S Peter, Mach Robert H, Spitzer Dirk, Hawkins William G: The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer. Journal of experimental & clinical cancer research : CR 36(1): 14, Jan 2017.

George Erin, Kim Hyoung, Krepler Clemens, Wenz Brandon, Makvandi Mehran, Tanyi Janos L, Brown Eric, Zhang Rugang, Brafford Patricia, Jean Stephanie, Mach Robert H, Lu Yiling, Mills Gordon B, Herlyn Meenhard, Morgan Mark, Zhang Xiaochen, Soslow Robert, Drapkin Ronny, Johnson Neil, Zheng Ying, Cotsarelis George, Nathanson Katherine L, Simpkins Fiona: A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers. JCI insight 2(1): e89760, Jan 2017.

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Last updated: 07/31/2017
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