Leonard None Jarett, M.D.

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Contact information
Department of Pathology and Laboratory Medicine
University of Pennsylvania Health System
280 John Morgan Bldg - 3600 Hamilton Walk
Philadelphia, PA 19104
Office: 215-662-6874
Fax: 215-573-2350
Education:
B.A. (Biology)
(Honors), Rice Institute, Houston, TX, 1958.
M.D. (medicine)
(Cum Laude), Washington University School of Medicine, St. Louis, MO, 1962.
M.A.
(Honorary), University of Pennsylvania, Philadelphia, PA, 1982.
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Selected Publications

Sachais, B., Kuo, A., Morgan, J., Kariko, K., Poncz, M., Williams, K., Feldman, M.,Shah, N., Jarett, L., Higazi, A.,and Cines, D.: Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic itinerary, resulting in retention of low-density lipoprotein on the cell surface. Blood in press 2002.

Vansal SS., Harada S., Jarett L.: Pervanadate increases glucose uptake in MCF-7 breast cancer cells by a new undefined pathway that is insulin and insulin receptor substrate-1 (IRS-1) independent. April 2001 Notes: poster. Exp. Biol. 2001,Orlando, FL.

Harada S., Vansal SS., Smith JA., Jarett L.: Insulin receptor substrate-1 (IRS-1) increases tyrosine phosphorylation of the insulin receptor (IR) by inhibiting protein tyrosine phosphatases (PTPases) in 3T3 adipocytes and MCF-7 breast cancer cells. February 2001 Notes: 1st International Workshop on Insulin Resistance, Amelia Island, FL.

Vansal SS., Harada S., Jaffri A., Smith JA., Jarett L.: Pervanadate increases glucose uptake in a novel, insulin receptor substrate-1 (IRS-1) independent manner and increases early growth response gene-1 (Egr-1) in an IRS-1 dependent manner in MCF-7 breast cancer cells. June 2001 Notes: American Diabetes Associateion 61st Scientific Sessions. Philadelphia, PA.

Shah N., Zelent D., Najafi H., Burke C., Raper S., Cuesta-Munoz A., Matchinsky F., Jarett L.: Electron microscopic demonstration of glucokinaes in insulin granules of rat pancreatic beta-cells. June 2001 Notes: American Diabetes Association 61st Scientific Sessions, Philadelphia, PA.

Vansal S., Cherynsh I., Shah N., Jarett L.: "Beta3-adrenergic agonist and insulin stimulate the translocation to the cell membrane and uncover a carboxy terminal epitope of GLUT-4 in a human brown adipocyte cell line". April 2000 Notes: Experimental Biology 2000, San Diego, California, April 15-18.

Harada S., Smith RM., Jarett L.: Mechanisms of nuclear translocation of insulin. [Review] [76 refs] Cell Biochemistry & Biophysics 31(3): 307-19, 1999.

Solow BT., Harada S., Goldstein BJ., Smith JA., White MF., Jarett L.: Differential modulation of the tyrosine phosphorylation state of the insulin receptor by IRS (insulin receptor subunit) proteins. Molecular Endocrinology 13(10): 1784-98, Oct 1999.

Solow BT., Derrien A., Smith JA., Jarett L., Harada S.: Angiotensin II inhibits insulin-induced egr-1 expression in mesangial cells. Archives of Biochemistry & Biophysics 370(2): 308-13, Oct 15 1999.

Harada S., Esch GW., Holgado-Madruga M., Wong A., Jarett L.: Grb-2 associated binder-1 (GAB-1) is involved in insulin-induced egr-1 gene expression through its phosphatidylinositol 3' (PI3')-kinase binding site. June 1999 Notes: ADA Meeting, San Diego, CA , June 19-22.

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Last updated: 08/27/2004
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