In Memoriam
Leonard None Jarett, M.D.
Contact information
Department of Pathology and Laboratory Medicine
University of Pennsylvania Health System
280 John Morgan Bldg - 3600 Hamilton Walk
Philadelphia, PA 19104
University of Pennsylvania Health System
280 John Morgan Bldg - 3600 Hamilton Walk
Philadelphia, PA 19104
Office: 215-662-6874
Fax: 215-573-2350
Fax: 215-573-2350
Email:
JARETT@MAIL.MED.UPENN.EDU
JARETT@MAIL.MED.UPENN.EDU
Publications
Education:
B.A. (Biology)
(Honors), Rice Institute, Houston, TX, 1958.
M.D. (medicine)
(Cum Laude), Washington University School of Medicine, St. Louis, MO, 1962.
M.A.
(Honorary), University of Pennsylvania, Philadelphia, PA, 1982.
Permanent linkB.A. (Biology)
(Honors), Rice Institute, Houston, TX, 1958.
M.D. (medicine)
(Cum Laude), Washington University School of Medicine, St. Louis, MO, 1962.
M.A.
(Honorary), University of Pennsylvania, Philadelphia, PA, 1982.
Selected Publications
Sachais, B., Kuo, A., Morgan, J., Kariko, K., Poncz, M., Williams, K., Feldman, M.,Shah, N., Jarett, L., Higazi, A.,and Cines, D.: Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic itinerary, resulting in retention of low-density lipoprotein on the cell surface. Blood in press 2002.Vansal SS., Harada S., Jarett L.: Pervanadate increases glucose uptake in MCF-7 breast cancer cells by a new undefined pathway that is insulin and insulin receptor substrate-1 (IRS-1) independent. April 2001 Notes: poster. Exp. Biol. 2001,Orlando, FL.
Harada S., Vansal SS., Smith JA., Jarett L.: Insulin receptor substrate-1 (IRS-1) increases tyrosine phosphorylation of the insulin receptor (IR) by inhibiting protein tyrosine phosphatases (PTPases) in 3T3 adipocytes and MCF-7 breast cancer cells. February 2001 Notes: 1st International Workshop on Insulin Resistance, Amelia Island, FL.
Vansal SS., Harada S., Jaffri A., Smith JA., Jarett L.: Pervanadate increases glucose uptake in a novel, insulin receptor substrate-1 (IRS-1) independent manner and increases early growth response gene-1 (Egr-1) in an IRS-1 dependent manner in MCF-7 breast cancer cells. June 2001 Notes: American Diabetes Associateion 61st Scientific Sessions. Philadelphia, PA.
Shah N., Zelent D., Najafi H., Burke C., Raper S., Cuesta-Munoz A., Matchinsky F., Jarett L.: Electron microscopic demonstration of glucokinaes in insulin granules of rat pancreatic beta-cells. June 2001 Notes: American Diabetes Association 61st Scientific Sessions, Philadelphia, PA.
Vansal S., Cherynsh I., Shah N., Jarett L.: "Beta3-adrenergic agonist and insulin stimulate the translocation to the cell membrane and uncover a carboxy terminal epitope of GLUT-4 in a human brown adipocyte cell line". April 2000 Notes: Experimental Biology 2000, San Diego, California, April 15-18.
Harada S., Smith RM., Jarett L.: Mechanisms of nuclear translocation of insulin. [Review] [76 refs] Cell Biochemistry & Biophysics 31(3): 307-19, 1999.
Solow BT., Harada S., Goldstein BJ., Smith JA., White MF., Jarett L.: Differential modulation of the tyrosine phosphorylation state of the insulin receptor by IRS (insulin receptor subunit) proteins. Molecular Endocrinology 13(10): 1784-98, Oct 1999.
Solow BT., Derrien A., Smith JA., Jarett L., Harada S.: Angiotensin II inhibits insulin-induced egr-1 expression in mesangial cells. Archives of Biochemistry & Biophysics 370(2): 308-13, Oct 15 1999.
Harada S., Esch GW., Holgado-Madruga M., Wong A., Jarett L.: Grb-2 associated binder-1 (GAB-1) is involved in insulin-induced egr-1 gene expression through its phosphatidylinositol 3' (PI3')-kinase binding site. June 1999 Notes: ADA Meeting, San Diego, CA , June 19-22.